To visualization map analyze the papers published on post-abortion care (PAC) in the past 10 years in China by knowledge graph software, and to know the current situation and future development trend of the researches on post-abortion care. Methods: With post-abortion care as the research theme, the literatures in CNKI, Wanfang and PubMed databases from January 2010 to December 2021 were retrieved. All the methods including cooperative network, keyword clustering, and keyword co-occurrence, were used in the visualization map analysis of the published years, authors, institutions, and keywords of the literature by VOSviewer and CiteSpace software. Results: A total of 546 Chinese literatures were included in this study. The result showed that the main institutions which published the literatures on PAC were National Research Institute for Family Planning, Changsha Maternal and Child Health Hospital, Tongde Hospital of Zhejiang Province, Zhengzhou Maternal and Child Health Hospital, Guangdong Maternal and Child Health Hospital, Peking University Shenzhen Hospital, and Jiading Central Hospital, etc. Key words with high frequency of occurrence in the literatures were abortion, post abortion care, repeated abortion, effect evaluation, influence factors, contraceptive knowledge and behaviors, and mental health, etc. Conclusion: At present, the PAC services are standardization, which can effectively reduce the occurrence of repeated abortion. It is considered that communication and cooperation of the research teams should be strengthened, and effective measures should be explored and formulated, so as to provide scientific evidences for further improving the quality of PAC service and female reproductive health level.

2023 Vol. 31　(4):　751- [Abstract]（ 562 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To analyze the trend of the body mass index (BMI) value of women during the preparing pregnancy after the implementation of the two-child policy. Methods: A total of 33 335 352 Han Chinese women who wanted pregnancy and had participated in the National Free Pre-pregnancy Health Checkup Program in 20132019 were included in this study. The average BMI value, the overweight rate, and the obesity rate of the women were calculated monthly. The primiparae in these women were included in control group, and the pluriparae in these women were included in study group. A controlled interruption time series analysis was conducted to obtain the trend of the BMI value of women before and after the implementation of the two-child policy. Results: Compared with those of the women in the control group, the mean monthly BMI value change of the women in the study group was 10.01×10-2kg/m2 (95%CI-0.07-19.94, P=0.05), and the change of the overweight/obesity rate of the women in the study group was 1.36% (95%CI 0.36%-2.35%, P<0.01). The results of subgroup analysis showed that the change of overweight rate of the women with age ≥35 years old, less than high school education level, or the farmer occupation in the study group was significantly higher than that of the women in the control group (P<0.05), and the obesity rate of the women with age ≥35 years old, and the average GPT of 40 000-50 000 Yuan, or reside in the first-tier city in the study group had significantly different from that of the women in the control group. In the trend change, the trend change of obesity rate of the women with the aged of 30-35 years old, the per capita GPT 50 000-70 000 Yuan or ≥70 000 Yuan, or reside in the second, the fourth, or the fifth tier cities had increased significantly (P<0.05), the trend change of overweight rate of the women with the aged of 30-50 years old, or reside in the third-tier city had increased significantly (P<0.05), and the trend change of overweight/obesity rate of the women with high school or above education level, vocational workers, or reside in the first or the third tier cities had decreased significantly (P<0.05). Conclusion: After the implementation of the universal two-child policy, there is little change in the overall trend of the BMI value among the women who are ready for pregnancy, and there are differences in the different social demographic characteristics and the different social development degree. The weight management of the women with planned pregnancy should be carried out to improve the health of the women of childbearing age.

2023 Vol. 31　(4):　763- [Abstract]（ 366 ） HTML (0 KB)  PDF  (0 KB)  ( 21 )

To evaluate the psychology and quality of reproductive life of women with assisted reproduction, and to analyze the factors affecting the quality of reproductive life of these women. Methods: Convenience sampling method was used to selected the women as respondents from 6 assisted reproductive medical institutions in Henan Province from June 2021 to May 2022. The general information questionnaire, symptom check list-90 (SCL-90), and reproductive quality of life questionnaire (FertiQoL) were used to investigate 626 respondents who received assisted reproduction. Results: The SCL-90 score showed that the obsessive-
compulsive symptoms, depression, and sleep/diet. The total score of FertiQoL of the women was 50.15±13.55 points, and which was significantly lower than that (53.34±12.49 points) of the selective treatment module and was significantly higher than that (48.81±15.97 points) of the core module. In the core module, the marital relationship score (58.40±14.88 points) of the women was significantly higher, while the psychosomatic relationship score of the women (39.46±23.10 points) was the lowest. The scores of the factors in SCL-90 scale of the women were negatively correlated with the cores of their FertiQoL total score, and the sores of core module and selective treatment module (P＜0.05). There was significant difference in the overall quality of life score among the women with different age, education level, occupation, infertility causes, infertility duration, treatment duration, and times of treatment failures, or between the women with and without biological children (P＜0.05). Linear regression analysis showed that the age, the education level, the treatment duration, the biological children, the times of treatment failures, and the SCL-90 total score of the women were the important factors influencing their quality of life (P＜0.05). Conclusion: The women with assisted reproduction generally have obvious obsessive-compulsive symptoms, depression, interrupted sleep/diet, and their psychological status and quality of life all are not ideal, so which should be paid attention to in clinic.

2023 Vol. 31　(4):　775- [Abstract]（ 498 ） HTML (0 KB)  PDF  (0 KB)  ( 21 )

2023 Vol. 31　(4):　787- [Abstract]（ 467 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To evaluate the effectiveness and safety of different dosages of alfentanil for anesthesia during the operation of transvaginal puncture and ova collection under ultrasound guidance. Methods: 120 patients who wanted IVF-ET were randomly divided into three groups (40 cases in each group) from January 2019 to September 2019. The patients in group A, group B, and group C were intravenous injection of alfentanil 5μg/kg, 7μg/kg, 9μg/kg, respectively, and then the patients in the three groups were given intravenous propofol 2mg/kg. The changes of the vital signs, the number of oocytes retrieved, the operation time, the time to wake up, the dosage and the rate of supplementation of propofol, the satisfaction rate of patients and doctors, and the incidence of adverse reactions of the patients in the three groups were recorded. Results: There were no significant differences in the number of oocytes retrieved, the operation time, the time to wake up, and the time to leave the room of the patients among the three groups (P＞0.05). The dosage of propofol (202.5±48.4mg) of the patients in group C was significantly less than that (251.6±45.3mg) of the patients in group A, and the rate of supplementation of propofol of the patients in group B (40.0%) and in group C (55.0%) was significantly lower than that (70.0%) of the patients in group A. The satisfaction rates of the surgeons and the anesthesiologists in group B (97.5% and 92.5%) and in group C (97.5% and 95.0%) were significantly higher than those (80.0% and 80.0%) in group A. The incidence of respiratory depression (30.0%) of the patients in group C was significantly higher than that (7.5%) of the patients in group A and that (12.5%) of the patients in group B. The incidence of body movement (45.0%) of the patients in group A was significantly higher than that (32.5%) of the patients in group B and that (17.5%) of the patients in group C (all P＜0.05). There were no significant differences in the values of MAP, HR, and SpO2 of the patients among the three groups (P＞0.05). There was no any patient with adverse event, such as nausea, vomiting, or cardiovascular. Conclusion: Afentanil 7μg/kg combined with propofol 2mg/kg used during the operation of transvaginal puncture and ova collection under ultrasound guidance has good anesthetic efficacy and safety.

2023 Vol. 31　(4):　799- [Abstract]（ 397 ） HTML (0 KB)  PDF  (0 KB)  ( 21 )

To observe the curative effect of labetalol combined with nifedipine for treating pregnant women with pregnancy-induced hypertension (PIH), and to study its influences on the coagulation function of these women. Methods: A total of 110 pregnant women with PIH were enrolled and were randomly divided into two groups (55 cases in each group) between January 2019 and January 2022. The women in the control group were treated with nifedipine, while the women in the observation group were treated with labetalol combined with nifedipine. After 2 weeks of treatment, the clinical curative effect, the changes of blood pressure value, renal function indexes, coagulation indexes, and umbilical artery blood flow of the women were compared between the two groups. The adverse pregnancy outcomes of the women in both groups were statistically analyzed. Results: After treatment, the effective rate (96.4%) of the women in the observation group was significantly higher than that (85.5%) of the women in the control group. The values of the blood pressure, the fibrinogen level, the ratio of umbilical artery systolic/diastolic pressure, and the values of pulsation indexes and resistance indexes of the women in the observation group were significantly lower than those of the women in the control group. The values of the prothrombin time, the activated partial thrombin time, and the thrombin time of the women in the observation group were significantly higher than those of the women in the control group. The incidence of adverse pregnancy outcomes (9.1%) of the women in the observation group was significantly lower than that (25.5%) of the women in the control group (all P＜0.05). Conclusion: Nifedipine combined with labetalol for treating the pregnant women with PIH can effectively improve their blood pressure value and blood hypercoagulability, and can increase their clinical curative effect.

2023 Vol. 31　(4):　808- [Abstract]（ 434 ） HTML (0 KB)  PDF  (0 KB)  ( 20 )

To explore the clinical effect of different doses of pulmonary surfactant combined with nasal non-invasive high-frequency ventilation for treating preterm infants with respiratory distress syndrome (RDS). Methods: The data of 121 preterm infants with RDS from January 2019 to January 2022 were collected. According to the different drug doses, these infants were divided into two groups. 62 infants in the study group were given treatment of high-dose pulmonary surfactant (100 mg/kg) combined with nasal non-invasive high-frequency ventilation and 59 infants in the control group were given treatment of low-dose pulmonary surfactant (70 mg/kg) combined with nasal non-invasive high-frequency ventilation. The hospitalization time, the time of respirator used, the clinical efficacy, the values of blood gas analysis indexes, and the pulmonary oxygenation function indexes, such as ratio of arterial oxygen partial pressure to alveolar oxygen partial pressure (a/APO2) and oxygenation index (OI), and the complications rate of the infants were compared between the two groups. Results: The duration of hospital stay (10.3±2.3d) and the time of respirator used (81.7±14.3h) of the infants in the study group were significantly lower than those (13.9±2.2d and 125.2±17.9h) of the infants in the control group. The total effective rate (95.2%) of the infants in the study group was significantly higher than that (81.4%) of the infants in the control group (all P＜0.05). There was no significant difference in the pH value of the infants between the two groups (P＞0.05). The changes of a/APO2 and OI levels of the infants in the study group were significantly better than those of the infants in the control group (P＞0.05). There was no significant difference in the complication rate (8.1% vs. 13.6%) of the infants between the two groups (P＞0.05). Conclusion: 100 mg/kg pulmonary surfactant combined with nasal noninvasive high-frequency ventilation for treating preterm infants with RDS can increase the clinical effect and can improve the blood gas-related indexes and pulmonary oxygenation function of the infants betterly, with higher safety.

2023 Vol. 31　(4):　818- [Abstract]（ 952 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To explore the impacts of structured psychological intervention for treating patients after laparoscopic surgery of ectopic pregnancy on their anxiety and depression, stress response, and postoperative recovery. Methods: From January 2021 to October 2022, 100 patients with laparoscopic surgery (LS) of ectopic pregnancy were selected and were randomlydivided into control group (n=50) and study group (n=50). The patients in the control group received routine care, and the patients in the study group received structured psychological intervention based on the routine care. Self-rating anxiety (SAS) and self-depression scales (SDS) were used to evaluate the psychological status of the patients in the two groups at the time of admission and before entering the operating room. The stress indexes, such as mean arterial pressure (MAP) and heart rate (HR) of the patients in the two groups were measured at the time of admission, when entering the operating room, and before anesthesia. The postoperative recovery indicators of the patients in the two groups were recorded. Results: The scores of SAS and SDS (48.64±4.19 points and 51.02±4.25 points) of the patients in the study group before entering the operating room were significantly lower than those (54.89±6.13 points and 57.84±5.23 points) of the patients in the control group. The values of MAP and HR of the patients in the two groups at the time of entering the operating room and before anesthesia were significantly higher than those of the patients at admission. The MAP value (90.14±10.42 mmHg or 88.57±9.24 mmHg) and the HR value (75.52±6.18 times/min and 75.81±6.29 times/min) of the patients in the study group at the time of entering the operating room or before anesthesia were significantly lower than those (99.42±8.56 mmHg or 97.35±8.03 mmHg, and 83.33±5.85 times/min or 84.52±5.47 times /min) of the patients in the control group. The first exhaust time (23.8±5.3h), the feeding time (7.3±2.4h), the defecation time (1.7±0.5d), and the duration of hospitalization (3.5±0.8d) of the patients in the study group were significantly shorter than those (52.47±5.31h, 9.0±3.2h, 2.2±0.6d, and 4.0±0.9d) of the patients in the control group (all P＜0.05). Conclusion: Implementing structural psychological intervention for treating the patients with LS of ectopic pregnancy can effectively regulate their negative emotions, reduce their surgical stress, and shorten their postoperative recovery time.

2023 Vol. 31　(4):　827- [Abstract]（ 563 ） HTML (0 KB)  PDF  (0 KB)  ( 20 )

To explore the change difference of immune cell profile in decidua of pregnant women with missed abortion or induced abortion. Methods: From January 2019 to December 2021, 51 pregnant women with missed abortion were selected in study group, and another 51 pregnant women with normal early pregnancy who required induced abortion were selected in control group. The decidual tissues of the women in the two groups were collected during abortion. The expressions of immune cells in decidual tissues of the women in the two groups were detected by flow cytometry, and the comparative analysis of which was performed between the two groups. Results: The NK cells (CD56+), macrophages (CD14+), and T lymphocytes (CD3+) dominated the immune cell composition in decidua tissues of the women in the two groups. There were no significant differences in the proportions of CD56+, CD14+, CD3+, CD4+, CD8+, and CD19+ in decidua tissues of the women between the two groups (P＞0.05). In the different subgroups, the proportion of CD49a+CD103+ cells in NK cells, the proportion of M2 cells in macrophages, the proportion of Treg cells in CD4+T cells, and the expression of CD39 in the decidua tissue of the women in the study group were significantly lower than those of the women in the control group. The proportion of M1 cells and the expression of CD80 on the surface of the macrophages, and the expressions of PD-1 and CD161 on the surface of CD4+T and CD8+T cells of the women in the study group were significantly higher than those of the women in the control group (all P＜0.05). Conclusion: Compared with those of the women with normal pregnancy who experienced induced abortion during early pregnancy, the expressions of CD49a+ CD103+ in NK cells, the M1 macrophages, and the T cells with immune killing ability effector in decidual tissue of the pregnant women with missed abortion increase, and their Treg cells with immunosuppressive function decrease, and the changes of which may contribute to the occurrence of missed abortion of the women.

2023 Vol. 31　(4):　837- [Abstract]（ 437 ） HTML (0 KB)  PDF  (0 KB)  ( 18 )

To investigate the risk factors of the occurrence of postpartum stress urinary incontinence (SUI), and to establish and verify the nomogram prediction model for the risk factors of SUI. Methods: The clinical data of 360 women who underwent pelvic floor function screening between June 2020 and September 2021 were reviewed retrospectively. Logistic regression was used to predict the independent influencing factors of SUI, and the meaningful factors of which were screened to establish the nomogram prediction model for the risk factors of postpartum SUI. Receiver operating characteristic (ROC) curve was used to analyze the predictive efficacy of the nomogram prediction model for SUI. Results: The incidence of SUI was 25.0%. Univariate analysis showed that the number of pregnancies, the residence, the occupation during pregnancy, the education level, the monthly income per capita, the mode of delivery, the SUI during pregnancy, and the abortion history of the women were related to the occurrence of their postpartum SUI. Multivariate analysis showed that the number of pregnancies ≥2 times, the rural residence, the occupational physical labor, the vaginal delivery, the occurrence of SUI during pregnancy, and the history of abortion of the women were the independent risk factors of their postpartum SUI. Based on the results of multi-factor analysis, the nomogram prediction model for postpartum SUI was established, the area under ROC curve of which for predicting SUI was 0.887 (95%CI 0.821-0.915) (P＜0.01). The BOOTSTRAP method used for verification by 500 resamples showed that the fitted curve of the nomogram prediction model had no obvious difference from its ideal curve, with good consistency. Conclusion: The number of pregnancies ≥2 times, the rural residence, the occupational physical labor, the vaginal delivery, the occurrence of SUI during pregnancy, and the history of abortion of the women are the independent risk factors of the occurrence of their postpartum SUI, which should be paid attention to and be early intervention in clinic.

2023 Vol. 31　(4):　848- [Abstract]（ 495 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

2023 Vol. 31　(4):　858- [Abstract]（ 373 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

2023 Vol. 31　(4):　869- [Abstract]（ 1287 ） HTML (0 KB)  PDF  (0 KB)  ( 18 )

To analyze the factors of chromosome abnormality in chorionic villus after spontaneous abortion of infertile patients with assisted reproductive technology (ART). Methods: From April 2018 to March 2020, 113 infertile patients with spontaneous abortion after ART treatment were collected. The patients were divided into study group (n=61) and control group (n=52) according to the results of G-banding karyotype analysis of chorionic villus tissue. The occurrence and type of chromosome abnormality in chorionic villus tissue, and the risk factors of the chromosome abnormality of the patients were analyzed. Results: Among 113 patients, there were 61 cases with abnormal chromosome, and the incidence was 54.0%. Among them, the triploid of chromosome accounted for the highest proportion (59.0%). The incidence of chromosome abnormality of the patients with 36-50 years old was significantly higher than that of the patients with 20-35 years old, and which of the patients with spontaneous abortion ≥3 times was significantly higher than that of the patients with spontaneous abortion 2 times (all P＜0.05). There was no significant difference in the incidence of chromosome abnormality between the patients with and without mycoplasma infection, among the patients with different times of uterine operation before ART, or among the patients with different methods of embryo transfer (P＞0.05). The advanced age and the spontaneous abortion ≥3 times of the patients with ART were the factors of their chromosome abnormality in villus tissues after spontaneous abortion (P＜0.05). Conclusion: The advanced age and the times of spontaneous abortion of the patients with ART are the risk factors of their chromosome abnormality in villus tissues.

2023 Vol. 31　(4):　877- [Abstract]（ 476 ） HTML (0 KB)  PDF  (0 KB)  ( 16 )

2023 Vol. 31　(4):　884- [Abstract]（ 1257 ） HTML (0 KB)  PDF  (0 KB)  ( 20 )

2023 Vol. 31　(4):　894- [Abstract]（ 339 ） HTML (0 KB)  PDF  (0 KB)  ( 16 )

To analyze the diagnostic value of the results of magnetic resonance imaging (MRI) combined with the levels of serum soluble FMS like tyrosine kinase-1 (sFlt1) and alpha fetoprotein (AFP) of pregnant women for their placenta previa and placenta accreta. Methods: The clinical data of 278 pregnant women with suspected placenta previa and placenta accreta from January 2021 to January 2022 were collected. 142 women with confirmed placenta previa and placenta accreta based on pathological examination were included in study group, and another 136 health pregnant women were included in control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the serum sFlt-1 and AFP levels. Pearson method was used to analyze the correlation between the serum sFlt-1 level of the women in the study group and their AFP level. The pathological results were as the gold standard of dognosing placenta previa and placenta accreta, the diagnostic efficacy of MRI results and the serum sFlt-1 and AFP levels of the women for their placenta previa and placenta accreta was analyzed. Results: The levels of sFlt-1 (2.52±0.43 ng/ml) and AFP (62.91±7.19 U/ml) of the women in the study group were significantly higher than those (1.12±0.15 ng/ml and 30.72±3.57 U/ml) of the women in the control group. The expression levels of serum sFlt-1 and AFP of the women with adhesion, penetration, and implantation of placenta accreta in the study group had increased gradually (all P＜0.05). The serum sFlt-1 level of the women in the study group was positively correlated with their AFP level (P＜0.05). The proportions of uneven signal in placenta, the thickened blood vessel shadow in placenta, the unclear boundary between the placenta and the uterus of the women in the study group were significantly higher than those of the women in the control group, and the proportions of the bladder protrusion and local exudation of the uterus of the women in the study group were significantly lower than those of the women in the control group (all P＜0.05). The sensitivity (84.8%) and the accuracy (80.2%) of the results of MRI combined with the serum sFlt-1 and AFP levels of the women for diagnosing their placenta previa and placenta accreta were significantly higher than those of the results of MRI, the serum sFlt-1 level, or the AFP level alone. Conclusion: The levels of serum sFlt-1 and AFP of the pregnant women with placenta previa and placenta accreta are increased abnormally. The results of MRI combined with the serum sFlt-1 and AFP levels of the women for diagnosing their placenta previa and placenta accreta can improve the sensitivity.

2023 Vol. 31　(4):　903- [Abstract]（ 343 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

2023 Vol. 31　(4):　912- [Abstract]（ 403 ） HTML (0 KB)  PDF  (0 KB)  ( 18 )

To explore the predictive value of platelet derived growth factor (PDGF), epidermal growth factor (EGF), and soluble vascular endothelial growth factor receptor 1 (sFlt 1) of women with polycystic ovary syndrome (PCOS) for their insulin resistance. Methods: The clinical data of 102 women with PCOS from January 2019 to January 2022 were selected in this study. These women were divided into two groups according to the homeostasis model assessment estimated insulin resistance (HOMA-IR) value of the women, including 65 women with insulin resistant in study group and 37 women without insulin resistant in control group. The clinical data and serum levels of PDGF, EGF, and sFlt 1 of the women were compared between the two groups. Multiple stepwise regression was used to analyze the risk factors of insulin resistance of the women with PCOS. Receiver operating characteristic (ROC) curve was drawn to analyze the values of the levels of PDGF, EGF, sFlt 1 for predicting the insulin resistance of the women with PCOS. Results: The levels of PDGF (105.21±3.45 pg/ml) and EGF (3.24±0.51 ng/ml) of the women in the study group were significantly higher than those (42.64±3.14 pg/ml and 2.27±0.31 ng/ml) of the women in the control group. The serum sFlt 1 level (90.54±10.49 ng/L) of the women in the study group was significantly lower than that (138.65±10.17 ng/L) of the women in the control group (all P<0.05). Multiple stepwise regression analysis showed that the levels of serum PDGF, EGF, sFlt 1, fasting glucose, and fasting insulin, the body mass index value, the waist hip ratio, and the hairy and acne occurrences of the women with PCOS were all the independent risk factors of their insulin resistance (all P<0.05). Pears correlation analysis showed that the PDGF level, EGF level, and sFlt 1 level of the women had certain predictive value for their insulin resistance, and the area under the curve of which were 0.780, 0.830, and 0.800, respectively (P<0.05). Conclusion: The levels of PDGF, EGF, and sFlt 1 of the women with PCOS are abnormal, which have certain predictive value for their insulin resistance.

2023 Vol. 31　(4):　922- [Abstract]（ 342 ） HTML (0 KB)  PDF  (0 KB)  ( 18 )

To analyze the correlation between the pre-pregnancy body mass index (BMI) value and the placental growth factor (PlGF) level of pregnant women and the occurrence of their hypertensive disorder complicating pregnancy (HDCP), and to study the predictive values of the BMI value and the PlGF level of the women for their delivery outcomes. Methods: The medical records of 93 pregnant women with HDCP (in observation group) between January 2019 and April 2022 were collected retrospectively, and these women were divided into group A (women with gestational hypertension), group B (women with preeclampsia), and group C (women with severe preeclampsia) according to the severity of their HDCP. 50 healthy pregnant women were selected in control group during the same period. The data of the value of pre-pregnancy BMI and the serum PLGF level during 8-14 gestational weeks of the women were collected. Pearson correlation analysis was used to analyze the correlation between the value of pre-pregnancy BMI and the serum PLGF level of the women and the occurrence of their HDCP. Receiver operating characteristic (ROC) curve was drawn to analyze the values of the value of pre-pregnancy BMI and the serum PLGF level for predicting the delivery outcomes of the women. Results: The value of pre-pregnancy BMI (22.9±1.0 kg/m2) of the women in the observation group was significantly higher than that (20.8±0.9kg/m2) of the women in the control group, the serum PLGF level (36.59±4.38 pg/ml) of the women during the first trimester of pregnancy in the observation group was significantly lower than that (51.21±4.96 pg/ml) of the women in the control group. There were significant differences in the  pre-pregnancy BMI value and the PLGF level of the women during the first trimester of pregnancy among group A, group B, and group C (all P<0.05). The prepregnancy BMI value of the women was positively correlated with the occurrence of their HDCP, and the PLGF level of the women during the first trimester of pregnancy was negatively correlated with the occurrence of their HDCP (P<0.05). The overall incidence of adverse pregnancy outcomes of the women in group A (8.6%), group B (29.0%), and group C (55.6%) had increased gradually (P<0.05). The area under the curve (AUC) of the pre-pregnancy BMI value, the PLGF level during the first trimester of pregnancy, and the combined of the pre-pregnancy BMI value and the PLGF level of the women with HDCP for predicting their pregnancy outcomes were 0.836, 0.894, and 0.925, respectively, and the AUC of the combined of the pre-pregnancy BMI value and the PLGF level was the highest. Conclusion: There is significant correlation between the pre-pregnancy BMI value and the PLGF level during the first trimester of pregnancy of the pregnant women and their occurrence of HDCP. Both the pre-pregnancy BMI value and the PLGF level during the first trimester of pregnancy of the pregnant women with HDCP have high predictive value for their delivery outcomes.

2023 Vol. 31　(4):　932- [Abstract]（ 497 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To investigate the diagnostic value of ultrasonic detection of fetal nuchal translucency (NT) combined with the levels of serum human chorionic gonadotropin β(β hCG) and pregnancy associated plasma protein A (PAPP A) of pregnant women for the chromosomal karyotype abnormality of their fetuses during the first trimester of pregnancy. Methods: 88 pregnant women with the suspicious fetal chromosomal karyotype abnormality after comprehensive pregnancy screening who wanted confirmed by amniotic fluid karyotype analysis of the fetuses during the first trimester of pregnancy were selected in this study from January 2018 to January 2022. According to the results of the fetal karyotype analysis, these women were divided into group A (77 women with normal fetal karyotype) and group B (11 women with abnormal fetal karyotype). The levels of serum β hCG and PAPP A, and the fetal NT value of the women were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the value of the levels of serum β hCG and PAPP A, and the fetal NT value of the women for diagnosing their fetal abnormal chromosome karyotype. Results: Among 88 women, there were 11 (12.5%) cases with abnormal fetal karyotype. Theβ HCG level and the fetal NT value of the women in group B were significantly higher than those of the women in group A, and the PAPP A level of the women in group B was significantly lower (P<0.05). The serum PAPP A level, the serum β HCG level, the fetal NT value, and the positive rate of the combined serum PAPP A and β HCG levels and fetal NT value for predicting the abnormal fetal karyotype of the women in group B were significantly higher than those of the women in group A (P<0.05). ROC analysis showed that the sensitivity, the specificity, and the area under the curve of the combined serum PAPP A and β HCG levels and fetal NT value of the women for diagnosing their fetal abnormal chromosome karyotype were 63.6%, 94.3%, and 0.798 (95% CI 0.6070.9489), respectively, and which were all significantly higher than those of the serum PAPP A level, the serum β HCG level, or the fetal NT value of the women alone (P<0.05). Conclusion: The serum PAPP A level, the serum β HCG level, and the fetal NT value of the women during the first trimester of pregnancy for diagnosing their fetal chromosomal karyotype abnormalities has certain values, and the combined serum PAPP A and β HCG levels and fetal NT value of the women for their fetal chromosomal karyotype abnormalities can increase the diagnostic values.

2023 Vol. 31　(4):　940- [Abstract]（ 455 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To explore the screening efficacy of the high risk human papilloma virus (HPV) E6/E7mRNA and HPV DNA for the cervical lesions of patients. Methods: 100 patients with positive TCT result as atypical squamous cell of undetermined significant (ASCUS) or above in routine physical examination, or the patients with contact bleeding, irregular vaginal bleeding, or vaginal abnormal discharge from October 2020 to October 2021 were collected. The detections of HPV E6/E7mRNA and HPV DNA and the cervical biopsy under the guidance of colposcopy of these patients were performed at the same time, and biopsy histopathology was used as the gold standard of the diagnosis of the cervical lesions. The expression levels of E6/E7 mRNA and DNA of high-risk subtypes HPV were analyzed. The detection rates of the cytology and histology were compared between the two detections of E6/E7 mRNA and DNA of high-risk subtypes HPV. Results: Based on the result of cytological diagnosis, there was no significant differences in the positive rates of HPV E6/E7 mRNA and HPV DNA (P>0.05). Based on the result of pathology as the gold standard, the positive rate of the detections of HPV E6/E7 mRNA and HPV DNA of the patients with >grading 2 of cervical intraepithelial neoplasia (CIN) was significantly higher than that of the patients with chronic cervicitis group or with grading 1 of CIN. The positive rate of HPV DNA detection of the patients with chronic cervicitis was significantly higher than that of HPV E6/E7 mRNA detection. The overall positive rate of HPV DNA detection of the patients was also significantly higher than that of HPV E6/E7 mRNA detection (all P<0.05). The results of pathology as the gold standard, the specificity (84.2%), the positive predictive value (71.7%), and the coincidence rate (81.8%) of HPV E6/E7 mRNA detection for screening the cervical lesions were significantly higher than those (51.4%, 45.2%, and 62.1%) of HPV DNA detection (all P<0.05), and there were no significant differences in the sensitivity and the negative predictive value between the two detections of HPV E6/E7 mRNA and HPV DNA for screening the cervical lesions (P>0.05). Conclusion: HPV E6/E7 mRNA detection can improve the specificity and the positive predictive value for screening the cervical lesions of the patients, and which can guide the shunting management of the cervical lesions.

2023 Vol. 31　(4):　949- [Abstract]（ 468 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To explore the effect of the external application of minced ginger on Neiguan acupoint combined with fluid infusion for treating pregnant women with hyperemesis gravidarum (HG) to relieve their nausea and vomiting symptoms. Methods: A total of 80 pregnant women with HG were selected and were randomly divided into two groups (40 cases in each group) from April 2020 to March 2021. The women in the control group were given intravenous infusion treatment and routine nursing, and the women in the study group were given the external application of minced ginger on Neiguan acupoint additionally. The treatment effect of the women was compared between the two groups. Results: The PUQE score (5.5±2.1) of the women in 48 and 72h after treatment in the study group was significantly lower than that (6.7±2.0) of the women in the control group (P<0.05). The time of urine ketone bodies turning negative and the time of hospital stay (2.3±1.1 d and 4.6±1.4 d) of the women in the study group were significantly shorter than those(3.2±1.6 d and 5.5±1.9 d) of the women in the control group (P<0.05). The scores of depression and anxiety (36.7±4.1 and 39.3±3.2) of the women in the study group were significantly lower than those (47.0±3.5 and 45.0±2.8) of the women in the control group (P<0.05). Conclusion: External application of minced ginger on Neiguan acupoint combined with fluid infusion for treating pregnant women with HG has better clinical effectiveness.

2023 Vol. 31　(4):　960- [Abstract]（ 366 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

To explore the related gene screening of pregnant population with high-risk of folic acid metabolism disorder, and to study the efficacy of the folic acid application. Methods: The clinical data of 1964 women with pre pregnancy examinations or with antenatal examination during the first trimester of pregnancy from January 2019 to January 2022 were collected. The A66G site of methionine synthase reductase (MTRR) gene and the related genes A1298C and C677T sites of methylenetetrahydrofolate reductase (MTHFR) gene of these women were detected by PCR technology. Folate metabolism risk assessment of these women had been conducted. 458 women without folate metabolism risk were in group A, and 1505 women with folate metabolism risk were in group B, including women with low, medium, or high folate metabolism risk. 1050 with medium or high folate metabolism risk were divided into group C (479 women with oral folic acid) and group D (571 women without oral folic acid). The adverse pregnancy outcomes, such as birth defects, premature delivery, spontaneous abortion, stillbirth, and the pregnancy related complications of the women in the two groups were counted. Results: The genotype and allele frequencies of MTHFR C677T, MTHFR A1298C, and MTRR A66G of the women in group B were significantly higher than those of the women in group A (P<0.05), but which of the women had no significant differences between the two groups (P>0.05). The incidences of the birth defects (1.3%), the spontaneous abortion (3.3%), the preterm delivery (4.0%), and the pregnancy-induced hypertension (4.0%) of the women in group C were significantly lower than those (6.0%, 7.0%, 8.4%, and 11.9%) of the women in group D (all P<0.05). There were no significant differences in the incidences of gestational diabetes mellitus and anemia of the women between group C and group D (P>0.05). The incidences of premature rupture of membranes (0.8%) and abnormal amniotic fluid (3.9%) of the women in group C were significantly lower than those (2.0% and 7.9%) of the women in group D. There were no significant differences in the incidences of placenta previa, placental abruption, and abnormal umbilical cord of the women between group C and group D (P>0.05). Conclusion: MTHFR and MTRR gene sites may be the potential influencing factors of the high risk of pregnancy diseases caused by folic acid metabolism disorder. The scientific administration of folic acid can effectively reduce the pregnancy complications and improve the adverse pregnancy outcomes of the women.

2023 Vol. 31　(4):　968- [Abstract]（ 399 ） HTML (0 KB)  PDF  (0 KB)  ( 20 )

To investigate the effect of multimodal transvaginal hysterofallopian tube contrast ultrasonography (HyCoSy) for diagnosing the patency of fallopian tube. Methods: The clinical data of 248 infertile patients from January 2020 to January 2022 were collected in this study. The patency of fallopian tube of these patients were evaluated by transvaginal multimodal HyCoSy and by transvaginal single-modal HyCoSy, and the diagnostic efficiencies of the modal parameters of transvaginal multimodal HyCoSy and transvaginal single-modal HyCoSy were analyzed. Results: 248 included patients all had completed the examination with salpingography of 496 fallopian tubes successfully, including 415 fallopian tubes with patency and 81 fallopian tubes with obstructed. In the fallopian tubes with obstructed, there were 28 tubes on the right side, 33 tubes on the left side, and 10 tubes on both sides. The diagnostic efficiency for the patency of fallopian tube was different between the transvaginal multimodal HyCoSy and the transvaginal single-modal HyCoSy. As for 4D single mode, the situations of 464 (93.5%) fallopian tubes were successfully diagnosed, while the situations of 32 (6.5%) fallopian tubes could not be diagnosed. The 4D mode combined with multimodal HyCoSy of 3D, 2D, and HI had the successfully diagnosed rate (496 tubes,100.0%) for the patency of fallopian tubes (χ2=33.067，P=0.000). Conclusion: The efficiency of the combined technical parameters of multimodal HyCoSy for diagnosing fallopian tube patency has increased, which has important clinical application value for diagnosing the fallopian tube patency.

2023 Vol. 31　(4):　979- [Abstract]（ 415 ） HTML (0 KB)  PDF  (0 KB)  ( 19 )

The use of magnetic resonance imaging (MRI) during pregnancy is increasing because it provides high-quality cross-sectional anatomical and pathological descriptions without ionizing radiation. MRI is commonly used to evaluate the situations of acute abdominal and pelvic pain, nervous system abnormalities, fetal/placental abnormalities, tumors, infections, and/or cardiovascular abnormalities of the pregnant women. However, to date, the understanding of the safety of MRI during pregnancy, particularly regarding the administration of gadolinium based contrast agent (GBCA), which is capable of crossing the placental barrier, remains limited, raising the concerns about the possible negative effects on the health of the mother and fetus. Therefore, this paper reviews the safety of MRI and GBCA application during pregnancy at home and abroad, as well as the recommendations of current social guidelines, so as to provide some references for the application and correct understanding of MRI during pregnancy.

2023 Vol. 31　(4):　988- [Abstract]（ 393 ） HTML (0 KB)  PDF  (0 KB)  ( 18 )