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| Diagnostic value of brain ultrasound combined with related serum index for the neonatal hypoxic ischemic encephalopathy |
| 1.Meishan People's Hospital, Meishan, Sichuan Province, 620010; 2.Santai People's Hospital of Mianyang, Mianyang, Sichuan Province; 3.Zigong Maternal and Child Health Care Hospital, Zigong, Sichuan Province |
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Abstract To analyze the diagnostic value of brain ultrasound combined with related serum index for neonatal hypoxic ischemic encephalopathy (HIE). Methods: A total of 108 neonates with HIE (in study group) and 50 healthy neonates (in control group) from March 2019 to May 2022 were included in this study. All the neonates were given brain ultrasound examination. The detection rate of early white matter damage of neonates by brain ultrasound examination was analyzed. The values of peak systolic velocity (VS), end diastolic velocity (VD), and resistance index (RI) of middle cerebral artery (MCA) of the neonates in the two groups were recorded. The serum neuron specific enolase (NSE) level of the neonates in the two groups was measured. Receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic efficacy of brain ultrasound combined with serum index for neonatal HIE. Results: The detection rate of early white matter damage of neonates by brain ultrasound examination was 87.0%. The values of VS (46.32±12.67cm/s) and RI (0.65±0.16) of the neonates in the study group were significantly higher than those (39.64±10.04 cm/s and 0.54±0.12) of the neonates in the control group, and the VD value (10.87±2.01 cm/s) of the neonates in the study group was significantly lower than that (13.06±3.12 cm/s) of the neonates in the control group. The serum NSE level (13.26±3.25μg/L) of the neonates in the study group was significantly higher than that (9.52±2.13μg/L) of the neonates in the control group (all P<0.05). The AUC of the single index, such as early white matter damage, VS, VD, RI, and NSE, of the neonates for diagnosing their HIE were 0.935, 0.599, 0.732, 0.741, and 0.766, respectively, which was significantly lower than that (0.987, the largest) of the brain ultrasound examination results combined with the serum NSE level of the neonates, with the diagnostic sensitivity and the specificity of 97.2% and 98.0%. Conclusion: The serum NSE level of the neonates with HIE increases abnormally. The results of the brain ultrasound examination combined with the serum NSE level of the neonates for diagnosing their HIE has better efficacy.
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