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| Values of ultrasonographic elastic imaging parameters and the expression levels of serum microRNA-34a and sFlt-1 of women with uterine fibroids and their diagnostic values for uterine fibroids |
| Handan Maternal and Child Health Care Hospital, Hebei Province, 056000 |
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Abstract To investigate the values of ultrasonographic elastic imaging parameters of uterine artery, such as pulsation index (PI), resistance index (RI), elastic stress ratio (SR), and the expression levels of serum microRNA-34a (miR-34a) and sFlt-1 (soluble vascular endothelial growth factor receptor-1) of women with uterine fibroids, and to study their diagnostic values for uterine fibroids. Methods: 50 women with uterine fibroids were selected in study group, and 50 healthy women who accepted physical examination were selected in control group from April 2021 to April 2022. The values of PI, RI, and SR, and the expression levels of miR-34a and sFLt-1 of the women in the two groups were analyzed. The correlation between the miR-34a and sFLt-1 levels of the women with uterine fibroids and their clinical features and their uterine fibroids occurrence was observed. The diagnostic values of transabdominal ultrasonographic elastic imaging parameters and the levels of serum miR-34a and sFlt-1 of the women for their uterine fibroids were explored. Results: The values of PI and RI, and the miR-34a level of the women in the study group were significantly lower than those of the women in the control group, but the sFLt-1 level and the SR value of the women in the study group were significantly higher. The levels of miR-34a and sFLt-1 of the women with irregular vaginal bleeding in the study group were significantly higher than those women without irregular vaginal bleeding (all P＜0.05). The miR-34a level of the women was negatively correlated with the occurrence of their uterine fibroids, while the sFLt-1 level was positively correlated with the occurrence of their uterine fibroids. The elastic imaging parameters by abdominal ultrasound, and the serum miR-34a and sFLt-1 levels of the women all had a certain diagnostic value for their uterine fibroids. The value of the combined the elastic imaging parameters and the serum miR-34a and sFLt-1 levels for diagnosing uterine fibroids was significantly higher than the elastic imaging parameters or the serum miR-34a and sFLt-1 levels alone, and the area under the curve, the sensitivity, and the specificity of which were 0.901, 91.4%, and 94.1%, respectively. Conclusion: The values of PI, RI, and SR, and the miR-34a and sFLt-1 levels of the women with uterine fibroids are all abnormally, and the miR-34a and sFLt-1 levels of the women are correlation with their occurrence of uterine fibroids. The value of the combination of the elastic imaging parameters and the serum miR-34a and sFLt-1 levels for diagnosing uterine fibroids is higher.
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