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| Correlation between the levels of serum irisin and retinol binding protein 4 of pregnant women during the third trimester of pregnancy and the severity of their pregnancy induced hypertension and their influence on the pregnancy outcomes |
| The Second Hospital of Baoding, Baoding, Hebei Province, 071051 |
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Abstract To explore the correlation between the levels of serum irisin and retinol binding protein 4 (RBP 4) of pregnant women during the third trimester of pregnancy and the severity of their pregnancy induced hypertension (PIH), and to study the influence of levels of serum irisin and RBP 4 of the women with PIH on their pregnancy outcomes. Methods: From March 2021 to March 2022, 120 pregnant women with PIH were selected in study group, and according to the severity of their PIH, these women were divided into group A (37 cases with mild PIH), group B (50 cases with moderate PIH), and group C (33 cases with severe PIH). In addition, 60 normal pregnant women were selected in control group during the same period. The serum levels of irisin and RBP 4 of all the women were detected by enzyme linked immunosorbent assay. Pearson correlation analysis was used to analyze the correlation between the levels of irisin and RBP 4 of the women and the severity of their PIH. The pregnancy outcomes were compared among the women with different levels of irisin and RBP 4. Multivariate logistic regression analysis was used to analyze the factors affecting adverse pregnancy outcomes of the women with PIH. Results: The serum irisin level (254.60±28.74 ng/L) of the women in the study group was significantly lower than that (552.44±56.66 ng/L) of the women in the control group, and the RBP 4 level (42.25±5.22 mu g/ml) of the women in the study group was significantly higher than that (23.36±3.26 mu g/ml) of the women in the control group. The serum irisin level of the women in group A, in group C, and in group B had increased gradually, and the RBP 4 level of the women in group A, in group C, and in group B had decreased gradually (all P<0.05). Pearson correlation analysis showed that the level of serum irisin of the women during the third trimester of pregnancy was negatively correlated with the severity of their PIH (r=0.441, P<0.05), and the serum RBP 4 level of the women during the third trimester of pregnancy was positively correlated with the severity of their PIH (r=0.366, P<0.05). In pregnant women with PIH, the rate of the adverse pregnancy outcomes of the women with the irisin level >254.60ng/L was significantly lower than that of the women with the irisin level ≤254.60ng/L, and the rate of the adverse pregnancy outcomes of the women with the RBP 4 level>42.25μg/ml was significantly higher than that of the women with the RBP 4 level ≤42.25μg/ml. The serum irisin and RBP 4 levels, and the age of the women with PIH during the third trimester of pregnancy were all the risk factors influencing their pregnancy outcomes (P<0.05). Conclusion: The level of irisin of the women with PIH during the third trimester of pregnancy decreases, and their serum RBP 4 level increases, and both the levels of irisin and RBP 4 were related to the severity of PIH and the adverse pregnancy outcomes of the women, which can be used as the evaluated indicators for the severity of PIH and the adverse pregnancy outcomes in clinical.
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