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| Research progress of the correlation between the folic acid over supplementation and the reproductive risk |
| 1.Heilongjiang University of Traditional Chinese Medicine，Harbin, Heilongjiang Province, 150040; 2.The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine |
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Abstract Folic acid is involved in the synthesis of DNA and RNA, and which is the essential material for the growth and reproduction of cells and tissues, and also is one of the essential vitamins for the growth and development of the embryo. To prevent the occurrence of neural tube malformations of the offspring, women can take appropriate folic acid supplementation before and after pregnancy. The current clinical folic acid application often suffers from the problems of high supplementation dose and long duration, and the influence of the folic acid over supplementation still lacks evidences from systematic overview. In this paper, the results of relevant clinical studies and animal trials in China and abroad are presented, analyzed, and summarized, so as to evaluate the influence of excessive folic acid intake of the pregnant women on their reproductive risk. For the mother, the high doses of folic acid supplementation may lead to abnormal maternal immune function, increase the risk of gestational diabetes mellitus, and cause the abnormal homocysteine accumulation. For the offspring, the high doses of folic acid may increase the risks of obesity, asthma, metabolic, and neurological disorders. Folic acid supplementation for peri-pregnant women should be administered after testing, and the duration and the dose of folic acid supplementation should be controlled to avoid blind supplementation.
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