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| Predictive values of the pre-pregnancy body mass index and the placental growth factor level of pregnant women with hypertensive disorder complicating pregnancy for their delivery outcomes |
| Baodi District People's Hospital of Tianjin, Tianjin, 301800 |
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Abstract To analyze the correlation between the pre-pregnancy body mass index (BMI) value and the placental growth factor (PlGF) level of pregnant women and the occurrence of their hypertensive disorder complicating pregnancy (HDCP), and to study the predictive values of the BMI value and the PlGF level of the women for their delivery outcomes. Methods: The medical records of 93 pregnant women with HDCP (in observation group) between January 2019 and April 2022 were collected retrospectively, and these women were divided into group A (women with gestational hypertension), group B (women with preeclampsia), and group C (women with severe preeclampsia) according to the severity of their HDCP. 50 healthy pregnant women were selected in control group during the same period. The data of the value of pre-pregnancy BMI and the serum PLGF level during 8-14 gestational weeks of the women were collected. Pearson correlation analysis was used to analyze the correlation between the value of pre-pregnancy BMI and the serum PLGF level of the women and the occurrence of their HDCP. Receiver operating characteristic (ROC) curve was drawn to analyze the values of the value of pre-pregnancy BMI and the serum PLGF level for predicting the delivery outcomes of the women. Results: The value of pre-pregnancy BMI (22.9±1.0 kg/m2) of the women in the observation group was significantly higher than that (20.8±0.9kg/m2) of the women in the control group, the serum PLGF level (36.59±4.38 pg/ml) of the women during the first trimester of pregnancy in the observation group was significantly lower than that (51.21±4.96 pg/ml) of the women in the control group. There were significant differences in the pre-pregnancy BMI value and the PLGF level of the women during the first trimester of pregnancy among group A, group B, and group C (all P<0.05). The prepregnancy BMI value of the women was positively correlated with the occurrence of their HDCP, and the PLGF level of the women during the first trimester of pregnancy was negatively correlated with the occurrence of their HDCP (P<0.05). The overall incidence of adverse pregnancy outcomes of the women in group A (8.6%), group B (29.0%), and group C (55.6%) had increased gradually (P<0.05). The area under the curve (AUC) of the pre-pregnancy BMI value, the PLGF level during the first trimester of pregnancy, and the combined of the pre-pregnancy BMI value and the PLGF level of the women with HDCP for predicting their pregnancy outcomes were 0.836, 0.894, and 0.925, respectively, and the AUC of the combined of the pre-pregnancy BMI value and the PLGF level was the highest. Conclusion: There is significant correlation between the pre-pregnancy BMI value and the PLGF level during the first trimester of pregnancy of the pregnant women and their occurrence of HDCP. Both the pre-pregnancy BMI value and the PLGF level during the first trimester of pregnancy of the pregnant women with HDCP have high predictive value for their delivery outcomes.
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