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| Predictive value of the levels of platelet derived growth factor, epidermal growth factor, and soluble vascular endothelial growth factor receptor 1 of women with polycystic ovary syndrome for their insulin resistance |
| Cangzhou Central Hospital, Cangzhou, Hebei Province, 061000 |
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Abstract To explore the predictive value of platelet derived growth factor (PDGF), epidermal growth factor (EGF), and soluble vascular endothelial growth factor receptor 1 (sFlt 1) of women with polycystic ovary syndrome (PCOS) for their insulin resistance. Methods: The clinical data of 102 women with PCOS from January 2019 to January 2022 were selected in this study. These women were divided into two groups according to the homeostasis model assessment estimated insulin resistance (HOMA-IR) value of the women, including 65 women with insulin resistant in study group and 37 women without insulin resistant in control group. The clinical data and serum levels of PDGF, EGF, and sFlt 1 of the women were compared between the two groups. Multiple stepwise regression was used to analyze the risk factors of insulin resistance of the women with PCOS. Receiver operating characteristic (ROC) curve was drawn to analyze the values of the levels of PDGF, EGF, sFlt 1 for predicting the insulin resistance of the women with PCOS. Results: The levels of PDGF (105.21±3.45 pg/ml) and EGF (3.24±0.51 ng/ml) of the women in the study group were significantly higher than those (42.64±3.14 pg/ml and 2.27±0.31 ng/ml) of the women in the control group. The serum sFlt 1 level (90.54±10.49 ng/L) of the women in the study group was significantly lower than that (138.65±10.17 ng/L) of the women in the control group (all P<0.05). Multiple stepwise regression analysis showed that the levels of serum PDGF, EGF, sFlt 1, fasting glucose, and fasting insulin, the body mass index value, the waist hip ratio, and the hairy and acne occurrences of the women with PCOS were all the independent risk factors of their insulin resistance (all P<0.05). Pears correlation analysis showed that the PDGF level, EGF level, and sFlt 1 level of the women had certain predictive value for their insulin resistance, and the area under the curve of which were 0.780, 0.830, and 0.800, respectively (P<0.05). Conclusion: The levels of PDGF, EGF, and sFlt 1 of the women with PCOS are abnormal, which have certain predictive value for their insulin resistance.
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