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| Dosage selection and effect analysis of alfentanil for anesthesia during the operation of transvaginal puncture and ova collection under ultrasound guidance |
| 1. Xin'an International Hospital, Jiaxing, Zhejiang Province, 314000; 2. Jiaxing Maternal and Child Health Care Hospital, Jiaxing |
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Abstract To evaluate the effectiveness and safety of different dosages of alfentanil for anesthesia during the operation of transvaginal puncture and ova collection under ultrasound guidance. Methods: 120 patients who wanted IVF-ET were randomly divided into three groups (40 cases in each group) from January 2019 to September 2019. The patients in group A, group B, and group C were intravenous injection of alfentanil 5μg/kg, 7μg/kg, 9μg/kg, respectively, and then the patients in the three groups were given intravenous propofol 2mg/kg. The changes of the vital signs, the number of oocytes retrieved, the operation time, the time to wake up, the dosage and the rate of supplementation of propofol, the satisfaction rate of patients and doctors, and the incidence of adverse reactions of the patients in the three groups were recorded. Results: There were no significant differences in the number of oocytes retrieved, the operation time, the time to wake up, and the time to leave the room of the patients among the three groups (P＞0.05). The dosage of propofol (202.5±48.4mg) of the patients in group C was significantly less than that (251.6±45.3mg) of the patients in group A, and the rate of supplementation of propofol of the patients in group B (40.0%) and in group C (55.0%) was significantly lower than that (70.0%) of the patients in group A. The satisfaction rates of the surgeons and the anesthesiologists in group B (97.5% and 92.5%) and in group C (97.5% and 95.0%) were significantly higher than those (80.0% and 80.0%) in group A. The incidence of respiratory depression (30.0%) of the patients in group C was significantly higher than that (7.5%) of the patients in group A and that (12.5%) of the patients in group B. The incidence of body movement (45.0%) of the patients in group A was significantly higher than that (32.5%) of the patients in group B and that (17.5%) of the patients in group C (all P＜0.05). There were no significant differences in the values of MAP, HR, and SpO2 of the patients among the three groups (P＞0.05). There was no any patient with adverse event, such as nausea, vomiting, or cardiovascular. Conclusion: Afentanil 7μg/kg combined with propofol 2mg/kg used during the operation of transvaginal puncture and ova collection under ultrasound guidance has good anesthetic efficacy and safety.
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