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| Correlation between the percentage of body fat and the triglyceride level of pregnant women and their gestational diabetes mellitus |
| The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People’s Hospital, Jiangsu Provincial Maternal and Child Health Care Hospital, Nanjing, Jiangsu Province, 210029 |
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Abstract To evaluate the correlation between the percentage of body fat (PBF) and the triglyceride (TG) level of pregnant women and their gestational diabetes mellitus (GDM. Methods: 81 pregnant women with GDM who received prenatal care in hospital were included in study group, and 162 healthy pregnant women matching as 1:2 in age and weight were recruited in control group from January to October 2021. The PBF during the first trimester of pregnancy and the TG level during the second trimester of pregnancy of the women were compared between the two groups. The influencing factors of GDM of the women were analyzed. The predictive values of the PBF and TG level of the pregnant women for their GDM were evaluated. Results: The PBF (34.9±5.2 %) and the TG level (2.4±0.8) mmol/L of the women in the study group were significantly higher than those (30.0±4.8% and 1.9±0.6 mmol/L) of the women in the control group (P<0.05). The ratios of the women with PBF >33.6% (48.1%) and with the TG level >2.3 mmol/L (49.4%) in the study group were significantly higher than those (21.6% and 20.4%) in the control group (P<0.05). Multivariate logistic regression analysis showed that the PBF >33.6% and the TG level >2.30 mmol/L of the women were the independent risk factors of their GDM occurrence (P<0.05). The risk of GDM occurrence of the women with the PBF >33.6% and the TG level >2.30 mmol/L was 8.005 times of the women with the PBF≤33.6% and the TG level≤2.30 mmol/L (95%CI 3.006-18.662). The interaction attribution percentage (AP) of the PBF and the TG level for GDM was 0.632 (95%CI 0.224-1.039). The area under the curve, the sensitivity, the specificity, and Yoden index of the PBF and the TG level combined with the conventional risk factors for predicting GDM were 0.791 (95%CI 0.734-0.849), 80.9%, 60.5%, and 0.414, respectively. Conclusion: The high PBF and the high TG level of the women during pregnancy are relevant to the increased risk of their GDM occurrence. The PBF and the TG level may have synergistic effect on the development of GDM, and which combined with the conventional risk factors has certain predictive value for the occurrence of GDM.
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