To investigate the effects of preemptive analgesia with flurbiprofen axetil on the dosage and the anesthetic effect of propofol during painless induced abortion. Methods: 90 women who wanted painless abortion were selected and were randomly divided into two groups according to their different admission time from January 2021 to July 2022. The women in the two groups were given same anesthetized way during painless induced abortion, 40 women in the control group were given sodium chloride injection intravenously before anesthesia induction, and 50 women in the study group were given flurbiprofen axetil injection intravenously before anesthesia induction. The perioperative hemodynamic indexes, the anesthetic effect, the propofol dosage, and the adverse reactions rate of the women were compared between the two groups. Results: There were no significant differences in the values of systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and oxygen saturation (SpO2) of the women before surgery between the two groups (P＞0.05). The values of SBP, DBP, HR, and SpO2 of the women in the two groups during abortion were significantly lower than those before abortion (P＜0.05). The HR value of the women in the study group was significantly higher than that of the women in the control group (P＜0.05). The SBP, DBP, HR, and SpO2 values of the women in the two groups when awaking after abortion had no significant different from those before abortion (P＞0.05). The operation time (4.33±0.37 min), the recovery time after anesthesia (4.62±1.52 min), the propofol dosage (2.50±0.32 mg/kg), and the total incidence of adverse reactions (22.0%) of the women in the study group were significantly lower than those (5.12±0.29 min, 6.91±2.32 min, 3.31±0.42 mg/kg, and 42.5%) of the women in the control group, but the total effective rate of anesthesia (94.0%) of the women in the study group was significantly higher than that (77.5%) of the women in the control group (P＜0.05). Conclusion: The application of flurbiprofen axetil for preemptive analgesia of the women during the painless abortion can effectively improve their anesthetic effect, reduce the dosage of propofol, reduce their occurrence of anesthetic-related adverse reactions, and shorten their abortion time and anesthesia recovery time.