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| Correlation between the levels of environmental air pollution indexes of women of childbearing age and the levels of their sex hormone and reproductive function indicators |
| General Hospital of Southern theatre command，Chinese People's Liberation Army, Guangzhou, Guangdong Province, 510010 |
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Abstract To analysis the correlation between the levels of environmental air pollution indicators of women of childbearing age and the levels of their sex hormone and reproductive function indicators. Methods: 957 childbearing age women who underwent physical examination in hospital from December 2021 to June 2022 were selected as the research objects. The levels of sex hormone and reproductive function indicators of these women were detected. The air quality data near the women were collected by ambient air monitoring stations. The impact of air pollutants on the sex hormones levels and reproductive function of the women were analyzed through the linear mixed effect model. Results: The levels of estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), antimueller's hormone (AMH), and statin B (INHB), and antral follicle count (AFC)of 957 women were 42.39±7.48pg/ml, 5.61±0.95IU/L, 7.34±0.86IU/L, 1.56±0.28ng/ml, 84.34±10.65pg/ml, and 7.17±1.58 number, respectively. Spearman correlation analysis showed that air PM2.5 concentration was highly correlated with the air PM10 and CO concentrations (r=0.87, 0.86, P＜0.05). The air PM10 concentration was highly correlated with the air CO and SO2 concentrations (r=0.74, 0.72, P＜0.05). The levels of E2, FSH, LH, AMH, and INHB, and the AFC of the women had decreased when the concentrations of air PM2.5, PM10, CO, NOx, and O3 increased, and the levels of AMH decreased when the concentration of SO2 increased (all P＜0.05), and which had hysteresis effect and cumulative effect, and the cumulative effect reached the maximum on the 5th day of the accumulation. Conclusion: The sex hormones levels and reproductive function of the women of childbearing age are in the normal range in this survey. With the increase of air pollutants concentrations, the sex hormones levels and reproductive function of the women decline, and which have hysteresis effect and cumulative effect.
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