|
|
|
| Correlation between the antiphospholipid antibody level of pregnant women with preeclampsia and the values of their coagulation and fibrinolysis indexes |
| The Second Second People's Hospital of Liaocheng, Liaocheng, Shandong Province, 252600 |
|
|
|
|
Abstract To analyze the correlation between the antiphospholipid antibody (APA) level of pregnant women with preeclampsia (PE) and the values of their thrombotic diseases indexes. Methods: 75 pregnant women with PE were selected in study group and another 50 healthy pregnant women were selected in control group from August 2019 to March 2022. The blood samples of the women in the two groups were collected. The levels of serum APA-IgG, APA-IgM, and anti-β2-GPI of the women in the two groups were detected by enzyme-linked immunosorbent assay. The D-dimer level, and the values of activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), antithrombin Ⅲ, and platelet aggregation test (PAgT) of the women in the two groups were detected by blood coagulation analyzer. The APA and anti-β2-GPI antibodies levels and the coagulation and fibrinolysis indexes values of the women were compared between the two groups. Spearman correlation method was used to analyze the correlation between the antibody level of the women and their coagulation and fibrinolysis indexes values. Results: The levels of APA-IgG, APA-IgM, and anti-β2-Gpi antibodies of the women in the study group were significantly higher than those of the women in the control group (all P＜0.05), but there was no significant difference in the APTT level of the women between two groups (P＞0.05). The levels of D-dimer, FIB, and PAgT of the women in the study group were significantly higher than those of the women in the control group. The levels of PT and antithrombin Ⅲ of the women in the study group were significantly lower than those of the women in the control group (all P＜0.05). In the study group, there was no significant difference in the PT level between the women with positive APA-IgG, APA-IgM, and anti-β2-GPI and the women with negative APA-IgG, APA-IgM, and anti-β2-GPI (P＞0.05). The levels of D-dimer, FIB, and PAgT of the women with positive APA-IgG, APA-IgM, and anti-β2-GPI were significantly higher than those of the women with negative APA-IgG, APA-IgM, and anti-β2-GPI, but which of the women with positive positive antithrombin Ⅲ were significantly lower than those of the women with negative antithrombin Ⅲ (all P＜0.05). Spearman correlation analysis showed that the levels of APA-IgG, APA-IgM, and anti-β2-GPI antibodies of the women were positively correlated with the levels of their D-dimer, FIB, and PAgT, and which were negatively correlated with the antithrombin Ⅲ level of the women (all P＜0.05). Conclusion: The levels of APA-IgG, APA-IgM, and anti-β2-GPI antibodies of the pregnant women with PE increase, and which are related to the coagulation and fibrinolysis indexes of the women.
|
|
|
|
|
|
|
|
|
