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| Curative effect of labetalol combined with nifedipine for treating women with pregnancy-induced hypertension and its influences on the coagulation function |
| Ya'an People's Hospital, Ya'an, Sichuan Province, 625000 |
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Abstract To observe the curative effect of labetalol combined with nifedipine for treating pregnant women with pregnancy-induced hypertension (PIH), and to study its influences on the coagulation function of these women. Methods: A total of 110 pregnant women with PIH were enrolled and were randomly divided into two groups (55 cases in each group) between January 2019 and January 2022. The women in the control group were treated with nifedipine, while the women in the observation group were treated with labetalol combined with nifedipine. After 2 weeks of treatment, the clinical curative effect, the changes of blood pressure value, renal function indexes, coagulation indexes, and umbilical artery blood flow of the women were compared between the two groups. The adverse pregnancy outcomes of the women in both groups were statistically analyzed. Results: After treatment, the effective rate (96.4%) of the women in the observation group was significantly higher than that (85.5%) of the women in the control group. The values of the blood pressure, the fibrinogen level, the ratio of umbilical artery systolic/diastolic pressure, and the values of pulsation indexes and resistance indexes of the women in the observation group were significantly lower than those of the women in the control group. The values of the prothrombin time, the activated partial thrombin time, and the thrombin time of the women in the observation group were significantly higher than those of the women in the control group. The incidence of adverse pregnancy outcomes (9.1%) of the women in the observation group was significantly lower than that (25.5%) of the women in the control group (all P＜0.05). Conclusion: Nifedipine combined with labetalol for treating the pregnant women with PIH can effectively improve their blood pressure value and blood hypercoagulability, and can increase their clinical curative effect.
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