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| Diagnostic value of ultrasonic detection of fetal nuchal translucency combined with the levels of serum human chorionic gonadotropin β and pregnancy associated plasma protein A of pregnant women for the chromosomal karyotype abnormality of their fetuses during the first trimester of pregnancy |
| The First People's Hospital of Nanyang, Henan Province, 473000 |
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Abstract To investigate the diagnostic value of ultrasonic detection of fetal nuchal translucency (NT) combined with the levels of serum human chorionic gonadotropin β(β hCG) and pregnancy associated plasma protein A (PAPP A) of pregnant women for the chromosomal karyotype abnormality of their fetuses during the first trimester of pregnancy. Methods: 88 pregnant women with the suspicious fetal chromosomal karyotype abnormality after comprehensive pregnancy screening who wanted confirmed by amniotic fluid karyotype analysis of the fetuses during the first trimester of pregnancy were selected in this study from January 2018 to January 2022. According to the results of the fetal karyotype analysis, these women were divided into group A (77 women with normal fetal karyotype) and group B (11 women with abnormal fetal karyotype). The levels of serum β hCG and PAPP A, and the fetal NT value of the women were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the value of the levels of serum β hCG and PAPP A, and the fetal NT value of the women for diagnosing their fetal abnormal chromosome karyotype. Results: Among 88 women, there were 11 (12.5%) cases with abnormal fetal karyotype. Theβ HCG level and the fetal NT value of the women in group B were significantly higher than those of the women in group A, and the PAPP A level of the women in group B was significantly lower (P<0.05). The serum PAPP A level, the serum β HCG level, the fetal NT value, and the positive rate of the combined serum PAPP A and β HCG levels and fetal NT value for predicting the abnormal fetal karyotype of the women in group B were significantly higher than those of the women in group A (P<0.05). ROC analysis showed that the sensitivity, the specificity, and the area under the curve of the combined serum PAPP A and β HCG levels and fetal NT value of the women for diagnosing their fetal abnormal chromosome karyotype were 63.6%, 94.3%, and 0.798 (95% CI 0.6070.9489), respectively, and which were all significantly higher than those of the serum PAPP A level, the serum β HCG level, or the fetal NT value of the women alone (P<0.05). Conclusion: The serum PAPP A level, the serum β HCG level, and the fetal NT value of the women during the first trimester of pregnancy for diagnosing their fetal chromosomal karyotype abnormalities has certain values, and the combined serum PAPP A and β HCG levels and fetal NT value of the women for their fetal chromosomal karyotype abnormalities can increase the diagnostic values.
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