To investigate the effect of Shenghua decoction combined with misoprostol for treating women with retained products of conception (RPOC) after natural delivery. Methods: 210 women with RPOC (excluding placenta accreta) after natural delivery of term pregnancy were randomly divided into three groups (70 cases in each group). The women in group A were given puerperal health education, the women in group B were given puerperal health education and oral misoprostol treatment, and the women in group C were given Shenghua Decoction combined with misoprostol treatment except to the puerperal health education. The clinical effect of the women in the three groups was observed. Results: There were significant differences in the total effective rate (65.2%, 80.3%, and 90.8%) and the total curettage rate (28.8%, 19.7%, and 10.7%) of the women among group A, group B, and group C (all P<0.05). The bleeding time during treatment, the proportion of maximum vaginal bleeding equal to or more than menstrual volume, the sum value of the three diameters of uterus by transvaginal ultrasound in the postpartum 42d, the time of menstrual recovery, the number of menstruations before recovery of the regular menstrual cycle, and the rate of menstrual volume reduction of the women in group C, in group B, and in group A had increased gradually. The menstrual days of the women in group C, in group B, and in group A had decreased gradually (all P<0.05). The number of menstrual cycles before the recovery of the regular menstrual cycle of the women in group A had significant different from that of the women in group B and that of the women in group C (P<0.05), while which of the women in group B had no significant different from that of the women in group C (P>0.05). After treatment, the proportion of exclusive breastfeeding of the women in the three groups had increased. The rate of exclusive breastfeeding and the excellent rate of exclusive breastfeeding of the women in group C were significantly higher than those of the women in group A and in group B (P<0.01). All the newborns after breast feeding by the women in the three groups during treatment had no abnormal situations, such as diarrhea, blood in the stool, or rash. There was no significant difference in the incidence of adverse reactions of the women between group B and group C (P>0.05). Conclusion: Shenghua decoction combined with misoprostol for treating the women with RPOC after natural delivery has better curative effect, which can promote the postpartum recovery of the women, can improve the treatment outcomes, and can promote breastfeeding, with safety, so it is worth of clinical application.