|
|
|
| Meta-analysis of the correlation between DAZL gene polymorphisms sites (A260G and A386G) of men in Asia and Caucasus and their infertility |
| Jiangsu Health Development Research Center, National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center, Nanjing, Jiangsu Province, 210036 |
|
|
|
|
Abstract To evaluate the correlation between DAZL gene polymorphisms sites (A260G and A386G) of men in Asia and Caucasus and their infertility. Methods: The Chinese and English databases, such as CNKI, Wanfang, Pubmed, and so on were searched for the case-control studies about the correlation between DAZL gene polymorphisms sites (A260G and A386G) of men in Asia and Caucasus and their infertility. State11.0 software was used for meta-analysis of the included literatures in the database from the establishment to October 2022. Results: A total of 18 case-control studies were retrieved, including 13 studies about the correlation between DAZL gene polymorphism site A260G of men in Asia and Caucasus and their infertility (3031 men in case group and 2029 men in control group), and 16 studies about the correlation between DAZL gene polymorphism site A386G of men in Asia and Caucasus and their infertility (4987 men in case group and 4201 men in control). No significant association was found in the results of the five comparative models between site A260G and site A386G. According to the race and genotyping methods, subgroup analysis showed that in the A386G site of DAZL gene in PCR-SSCP group, there were significant associations between G and A (OR=10.42, 95%CI 3.7329.10, Ph=0.811), between GA and AA (OR=10.69, 95%CI 3.80-30.08, Ph=0.885), and between GA+GG and AA (OR=10.90, 95%CI 3.88-30.66, Ph=0.855). Conclusion: The A260G site polymorphism of DAZL gene of the men in Asia and Caucasus has no correlation with their infertility. According to the genotyping methods, subgroup analysis finds that A386G site polymorphism of DAZL gene in PCR-SSCP group of the men in Asia and Caucasus is correlated with their infertility.
|
|
|
|
|
|
|
|
|
