To investigate the effect of multimodal transvaginal hysterofallopian tube contrast ultrasonography (HyCoSy) for diagnosing the patency of fallopian tube. Methods: The clinical data of 248 infertile patients from January 2020 to January 2022 were collected in this study. The patency of fallopian tube of these patients were evaluated by transvaginal multimodal HyCoSy and by transvaginal single-modal HyCoSy, and the diagnostic efficiencies of the modal parameters of transvaginal multimodal HyCoSy and transvaginal single-modal HyCoSy were analyzed. Results: 248 included patients all had completed the examination with salpingography of 496 fallopian tubes successfully, including 415 fallopian tubes with patency and 81 fallopian tubes with obstructed. In the fallopian tubes with obstructed, there were 28 tubes on the right side, 33 tubes on the left side, and 10 tubes on both sides. The diagnostic efficiency for the patency of fallopian tube was different between the transvaginal multimodal HyCoSy and the transvaginal single-modal HyCoSy. As for 4D single mode, the situations of 464 (93.5%) fallopian tubes were successfully diagnosed, while the situations of 32 (6.5%) fallopian tubes could not be diagnosed. The 4D mode combined with multimodal HyCoSy of 3D, 2D, and HI had the successfully diagnosed rate (496 tubes,100.0%) for the patency of fallopian tubes (χ2=33.067，P=0.000). Conclusion: The efficiency of the combined technical parameters of multimodal HyCoSy for diagnosing fallopian tube patency has increased, which has important clinical application value for diagnosing the fallopian tube patency.