-
WU Zheng1, WANG Cheng2, LI Liangliang1, YANG Lan1,2
To systematically evaluate the prevalence of the anxiety and depression of patients during the treatment of assisted reproductive technology. Methods: The databases, such as PubMed, Cochrane Library, EMBASE, Web of Science, CBM, CNKI and WanFang, from the inception dates to April 4, 2023 were searched by computer to collect the cross-sectional studies on the current status of the anxiety and depression of the patients during the treatment of assisted reproductive technology. Two researchers selected the literature, extracted the data and evaluated the risk of bias of the included studies independently. The meta-analysis was performed using Stata 15.1. Results: A total of 27 cross-sectional studies were included in for meta-analysis, with a total sample size of 9876 with anxiety and 13,207 patients with depressed. Meta analysis showed that the prevalence of the anxiety and the depression of the male patients were 13% and 28%, and the prevalence of the anxiety and the depression of the female patients were 32% and 36%. The subgroup analysis showed that the prevalence of the mild, moderate, and severe anxiety of the patients were 21.0%, 4.0%, and 0.6%, respectively, and the prevalence of the mild, moderate, severe and very severe depression of the patients were 28.0%, 11.0%, 1.0% and 0.3%, respectively. The prevalence of the anxiety of the patients with assisted reproductive technology in South China, Northwest China, Central China, Southwest China, North China and East China were 24%, 21%, 34%, 10%, 30% and 29%, respectively, and the prevalence of the depression of the patients with assisted reproductive technology in South China, Northwest China, Central China, Southwest China, North China and East China were 39%, 41%, 38%, 27%, 29% and 33%, respectively. Conclusion: The evidences available showed that the prevalence of anxiety and depression of the patients during the treatment of assisted reproductive technology is still at a high level, and which should be confirmed by more high-quality studies because of the limited of this meta-analysis by the quantity and the quality of the included studies.
2024 Vol. 32 (7): 1468- [Abstract]（
77
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
LIANG Zhaorui1, BAI Pengqian1, BAI Pengxing2, WANG Pei1
To investigate the psychological sense of entrapment and the quality of infertile women with advanced age, and to analyze their correlation with the marital support coping of the women. Methods: From January to December 2023, 212 infertile women with advanced age who visited the reproductive center of the hospital were selected as the study subjects by convenience-sampling method. The general data questionnaire was used to investigate the general data of these women. The entrapment scale (ES), the fertile quality of life scale (Ferti-QOL) and the dyadic coping inventory (DCI) were used to evaluate the psychological sense of entrapment and the quality of reproductive life of the women, and the marital support coping level. Results: The scores of ES, FertiQOL and DCI of the infertile women with advanced age were 33.65±5.61 points, 70.97±12.61 points and 107.95±12.04 points, respectively. Correlation analysis showed that the ES score of the women was negatively correlated with their Ferti-QOL and DCI scores, and the Ferti-QOL score of the women was positively correlated with their DCI score (all P<0.05). Logistic multiple regression analysis showed that the advanced age, the childless, the longer duration of infertility and the low annual family income of the infertile women were the independent risk factors of their psychological sense of entrapment, while the moderate and above scores of Ferti-QOL and DCI of the infertile women were the protective factors of their psychological sense of entrapment (all P<0.05). Conclusion: In this survey, the psychological sense of the infertile women with advanced age is at a medium level. The quality of reproductive life and the marital support coping of the women need to be improved, and which is conducive to reduce the psychological sense of entrapment of the women.
2024 Vol. 32 (7): 1478- [Abstract]（
75
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
XIAO Xinyan, LI Yanmin, ZHU Lihua
To investigate the depression current situation of pregnant women with scarred uterus (SU) during the third trimester of pregnancy, and to analyze the influencing factors of the depression. Methods: From January 2021 to December 2023, 278 pregnant women with SU who underwent prenatal examinations in hospital were selected in this study. These women were all evaluated by the patient health questionnaire (PHQ-9) during the third trimester of pregnancy, and based on the evaluation results, these women were divided into group A (women with depression) and group B (women without depression). The 17 items of the data in PHQ-9 of the women were collected and were compared between the two groups. Multivariate analysis was applied to screen the influencing factors of the depression occurrence of the pregnant women with SU during the third trimester of pregnancy. Results: 22.3% (62/278) women with SU had depression during the third trimester of pregnancy. There were significant differences in the educational background, the adverse pregnancy experience, the sleep status, the pregnancy complications rate, the introverted personality rate, the family care situation, and the recent negative life events of the women between group A and group B (P<0.05). The influencing factors of the depression occurrence of the pregnant women with SU during the third trimester of pregnancy mainly included the adverse pregnancy experience (OR=2.816, 95%CI 1.570-5.050), the poor sleep status (OR=2.514, 95%CI 1.377-4.589), and the introverted personality rate (OR=2.408, 95%CI 1.289-4.500), the poor family care (OR=3.022, 95%CI 1.708-5.316) and the recent negative life events (OR=2.862, 95%CI 1.577-5.193). Conclusion: The adverse pregnancy experiences, the poor sleep status, the introverted personality, the poor family care and the recent negative life events of the pregnant women with SU are related to their depression during the third trimester of pregnancy. Therefore, the targeted education, the psychological support and the health behavior interventions for these women based on these influence factors should be provided to prevent the occurrence of their depression.
2024 Vol. 32 (7): 1483- [Abstract]（
60
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
HU Jie, HE Yuping, WANG Xiumei, LI Yaya
To investigate the psychological health status of infertile patients before in vitro fertilization-embryo transfer (IVF-ET), and to study its correlation with the coping style of the patients. Methods: From January 2020 to December 2023, a total of 220 infertile patients who received IVE-ET for assisting pregnancy in the reproductive center of the hospital were selected in this study. The survey was conducted by the general information questionnaire, 90 symptom checklists (SCL-90), the fertility stress inventory (FPI), and the medical coping style questionnaire (MCMQ). Result: 211 infertile patients had completed the questionnaire survey, with the effective rate of 95.9%. The total score of SCL-90 of 211 infertile patients was 140.13±44.12 points, and which was significantly higher than that of the normal level (P<0.05). The total score of FPI was 166.04±21.69 points, and the scores of the face MCMQ, avoidance and yield of the patients were 18.45±2.89 points, 15.87±2.64 points and 9.36±2.81 points, and all of which were at the moderate level. The SCL-90 score of the patients was significantly negatively correlated with their face MCMQ score, and was positively correlated with their scores of PFI, avoidance and yielding. Meanwhile, the PFI score of the patients was negatively correlated with their face MCMQ score, and was positively correlated with their scores of avoidance and yielding (all P<0.05). Conclusion: The infertility patients generally have different degrees of the psychological health problems before IVF-ET, which are related to their coping styles. It is suggests that the clinical interventions should be carried out to guide the patients to adopt the positive coping styles and reduce the negative coping styles, which is conducive to improving their psychological health.
2024 Vol. 32 (7): 1488- [Abstract]（
74
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
CHENG Longhui1, XIAO Pei1, WANG Lei2, ZHANG Bin1, ZHANG Qu1
To investigate the current incidence of the infection after the contraceptive operation and its epidemiological trend, and to call on the medical and health industry to pay enough attention to the problem of the infection after the contraceptive operation. Methods: The incidence of the infection after the contraceptive operation was calculated using the data from China's Health Statistics Yearbook monitored between 2007 and 2020, which including the insertion and removal of intrauterine devices (IUD), the tubal sterilization, and the abortion. The estimated values of the annual percent change (APC) and the average annual percentage change (AAPC) were counted by Joinpoin regression model, and the trend analyses of the infection rates after the contraceptive operations were analyzed. Results: According to the data from China's Health Statistics Yearbook monitored between 2018 and 2020, the current infection rates of the patients after abortion, tubal ligation and IUD inserted (removal) in China were approximately 7.3/100,000, 5.6/100,000 and 5.6/100,000, respectively, and the overall infection rate of the patients after abortion, tubal ligation and IUD inserted (removal) was 6.6/100,000. From 2007 to 2020, the overall infection rate after the contraceptive operation, the infection rate after IUD inserted (removal) and the infection rate after abortion of the patients showed a decreasing trend, and the AAPC of which were -10.9%, -9.9% and -7.2%, respectively (all P<0.05). From 2007 to 2020, the infection rate of the patients after tubal ligation showed a decreasing trend (AAPC=-14.4, P<0.05), but the decreasing trend of the infection rate of the patients after tubal ligation had statistical significance from 2007 to 2012 (APC=-9.5, P<0.05). Conclusion: The prevention and control of the infections after the contraceptive operation in China has made the remarkable achievements, and the infection rate after the contraceptive operation is low, but the follow-up and the monitoring work after the contraceptive operation is still difficult, and which should be further paid attention to and be researched.
2024 Vol. 32 (7): 1493- [Abstract]（
66
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
LIU Qinwen, QI Ping, ZHANG Haiyan, WANG Xuan
To explore the effect of metformin for treating patients with polycystic ovary syndrome (PCOS), and to study its influence on the sex hormones levels, pregnancy rate and pregnancy complications of the patients. Methods: A randomized controlled trial was used in this study. From July 2021 to January 2023, 210 patients with PCOS were selected and were divided into control group (102 patients treated with ethinylestradiol cyproterone tablets) and observation group (108 patients treated with metformin) according to random number method. The values of the general condition indexes, such as body weight, body mass index (BMI) and waist-to-hip ratio (WHR), the levels of glucose metabolism indexes, such as fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR), the levels of lipid metabolism indexes, such as total cholesterol (TC), apolipoprotein A (apoA), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C), and the levels of sex hormone indexes, such as luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T) and estradiol (E2) of the patients before and after treatment were compared between the two groups. The pregnancy rate and the complications situation of the patients during pregnancy were followed up for 9 months after treatment continually. Results: After treatment, the values of body weight, BMI and WHR of the patients in the two groups had decreased significantly, and which (63.0±8.7 kg, 26.1±2.9 kg/m2 and 0.73±0.15) of the patients in the observation group were significantly lower than those (66.4±9.7 kg, 27.6±3.5 kg/m2 and 0.82±0.19) of the patients in the control group. The levels of FPG (4.01±0.96 mmol/L), FINS (18.69±2.94 mU/L) and the HOMA-IR value (3.30±0.88) of the patients in the observation group were significantly lower than those (4.96±1.10 mmol/L, 22.37±3.82 mU/L and 4.93±1.10) of the patients in the control group. The levels of TC, HDL-C and LDL-C of the patients in the two groups had decreased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group. The apoA level of the patients in the two groups had increased significantly, and which of the patients in the observation group was significantly higher than that of the patients in the control group. The levels of LH, T and E2 of the patients in the two groups had decreased significantly and the FSH level of the patients in the two groups had increased significantly, and the changes of which of the patients in the observation group were significantly greater than those of the patients in the control group (all P<0.05). Conclusion: Metformin for treating the patients with PCOS has better efficacy, which is conducive to improving the metabolism ability of the blood glucose and lipid, improving the endocrine function and to correcting the metabolic disorders of the patients, thus having a positive effect on improving the pregnancy rate and lowering the risk of the complications of the patients during pregnancy.
2024 Vol. 32 (7): 1498- [Abstract]（
52
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
XI Yiming, XU Mengdan, LIU Chunhong, LV Ling
To investigate the effects of laparoscopic lesion resection combined with uterine artery occlusion for treating patients with adenomyosis on their neutrophillymphocyte ratio (NLR), and their levels of carbohydrate antigen 125 (CA125) and transforming growth factor β1 (TGF-β1). Methods: 210 patients with adenomyosis were collected and were randomly divided into control group (105 cases with laparoscopic lesion resection) and observation group (105 cases with laparoscopic lesion resection combined with uterine artery occlusion) from September 2020 to August 2023. The surgical time, the intraoperative blood loss, the menstrual volume before surgery and in 6 months after surgery, the pain status, the uterine volume, the ovarian function, the NLR, and the levels of CA125 and TGF-β1 of the patients were compared between the two groups. Results: The intraoperative blood loss (276±35ml) and the operation time (87±25min) of the patients in the observation group were significantly lower than those (357±26ml and 115±36 min) of the patients in the control group. The menstrual volume in 6 months after surgery (12.44±2.14 pads/month), the VAS score (2.06±0.62 points), the uterine volume (89.47±14.25 cm3), the NLR (2.06±0.86), and the levels of CA125 (20.35±2.71 KU/L) and TGF-β1 (35.98±8.12 mg/L) of the patients in the observation group were significantly lower than those (15.63±1.56 pads/month, 2.45±0.78 points, 95.36±12.36 cm3, 2.45±0.95, 24.53±2.48 KU/L and 42.63±8.56 mg/L) of the patients in the control group. In 1 week after surgery, the level of estradiol (159.36±24.71 pg/ml) of the patients in the observation group was significantly lower than that (168.47±27.06 pg/ml) of the patients in the control group. The levels of luteinizing hormone (11.59±3.18 U/L) and follicle stimulating hormone (27.56±3.84 U/L) of the patients in the observation group were significantly higher than those (10.57±2.87 U/L and 26.51±3.49 U/L) of the patients in the control group (all P<0.05). In 6 months after surgery, there were no significant differences in the sex hormones levels of the patients between the two groups, and there was no any patient with the adenomyosis recurrence. Conclusion: Both laparoscopic lesion resection and laparoscopic lesion resection combined with uterine artery occlusion can be used to treating adenomyosis of the patients. Laparoscopic lesion resection combined with uterine artery occlusion for treating the patients with adenomyosis has more advantages in the surgical efficiency, the improvement of dysmenorrhea symptoms and reduction of the levels of NLR, CA125 and TGF-β1of the patients, and which has less impact on the ovarian function of the patients.
2024 Vol. 32 (7): 1503- [Abstract]（
53
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
HU Qin, WANG Jingyi
To explore the effect of lactobacillus vaginal capsule combined with metronidazole vaginal administration for treating patients with atrophic vaginitis. Methods: The clinical data of the patients with atrophic vaginitis admitted to outpatient department for treatment from January 2021 to August 2023 were analyzed retrospectively. 73 patients were randomly selected from the patients who had accepted treatment of metronidazole vaginal administration in control group, and 73 patients were randomly selected from the patients who had accepted treatment of metronidazole combined with lactobacillus vaginal capsule in observation group. The clinical efficacy and the positive rate of lactobacillus after 14 days of treatment of the patients were compared between the two groups. The distribution status of the vaginal flora (lactobacillu, enterobacter and candida albicans), the vaginal microecology, the vaginal microcirculation (erythrocyte aggregation rate) and the vaginal inflammatory factors levels of the patients in the two groups before and after treatment were recorded. Results: After 14 days of treatment, the total effective rate (90.4%) and the positive rate of lactobacillus (83.6%) of the patients in the observation group were significantly higher than those (74.0% and 68.5%) of the patients in the control group. The lactic acid bacteria content of the patients in the two groups after treatment had increased significantly, and which (8.94±1.48 cfu/ml) of the patients in the observation group was significantly higher than that (7.35±1.26 cfu/ml) of the patients in the control group. The aggregation rates of Enterobacter, Candida albicans and erythrocyte, and the inflammatory factors levels of the patients in the two groups after treatment had increased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group. The proportions of the secretion pH≤4.5 (91.8%), the flora density of grade II-III (87.7%) and the dominant bacteria of lactic acid bacteria (89.0%) of the patients in the observation group were significantly higher than those (67.1%, 71.2% and 69.9%) of the patients in the control group (all P<0.05). Conclusion: Metronidazole combined with lactobacillus vaginal capsule for treating the patients with atrophic vaginitis can help improve their vaginal microecology and microcirculation.
2024 Vol. 32 (7): 1508- [Abstract]（
73
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
WANG Wei, CHENG Qinwei, DU Fuyang, CHENG Dianping
To explore the analgesia effect of transversus abdominis plane block (TAPB) with the combined dexamethasone, dexmedetomidine and ropivacaine for puerperae after cesarean section. Methods: A total of 80 puerperae who had undergone cesarean section in the hospital were enrolled as the research objects between April 2021 and April 2023. After the surgery, all the puerperae were given ultrasound-guided bilateral TAPB for analgesia. According to the random number table method, these puerperae were divided into group D (40 cases with dexmedetomidine combined with ropivacaine for TAPB) and group S (40 cases with dexamethasone combined with ropivacaine for TAPB). The time of getting out of bed, the hospitalization stay, the time of the first analgesic pump compression, the number of the analgesic pump effective compression within postoperative 24h, the cumulative dosage of sufentanil, the maternal satisfaction, the scores of visual analogue scale (VAS) under rest/exercise state and the quality of recovery 40 questionnaire (QoR40) score, and the incidence of adverse reactions of the puerperae were compared between the two groups. Results: The time of getting out of bed (7.71±0.86 h), the duration of hospital stay (5.39±0.41d), the number of effective pressing analgesia pump within postoperative 24h (2.01±1.31 times) and the cumulative dosage of sufentanil used within postoperative (46.39±0.72μg) of the puerperae in group S were significantly lower than those (8.93±1.15h, 6.05±0.72d, 2.73±1.62 times and 48.33±0.63μg) of the puerperae in group D. The first analgesic pump pressing time (689.72±68.17min) and the maternal satisfaction (8.11±0.87) of the puerperae in group S were significantly higher than those (552.63±52.15min and 6.33±1.23) of the puerperae in group D. At 6h, 12h, 24h and 48h after operation, the VAS scores under rest/exercise state of the puerperae in group S at postoperative 6h, 12h, 24h and 48h were significantly lower than those of the puerperae in group D. The scores of comfort, emotion, self-care ability, social interaction, pain and QoR-40 of the puerperae in group S were significantly higher than those of the puerperae in group D. The total QoR-40 score (169.52±7.01 points) of the puerperae in group S was significantly higher than that (152.17±7.23) of the puerperae in group D (all P<0.05). There was no significant difference in the incidence of the adverse reactions of the puerperae between the two groups (P>0.05). Conclusion: Dexamethasone combined with ropivacaine for TAPB of the puerperae after cesarean section has better analgesia effect, which can effectively prolong the analgesia time, relieve the postoperative pain and improve the postoperative recovery quality of the puerperae, and with the better safety.
2024 Vol. 32 (7): 1513- [Abstract]（
73
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
LI Lingyan, YU Qing, ZHANG Shuai, HUANG Xiaojia MA Jinzhi
To explore the effect of the combination of remazolam besylate and remifentanil used during hysteroscopic surgery of patients, and to study it influence on the postoperative cognitive function of the patients. Methods: 90 patients who wanted hysteroscopic surgery were randomly divided into two groups from December 2021 to December 2023. 45 patients in control group received anesthesia by propofol combined with remifentanil, while 45 patients in observation group received anesthesia by remazolam besylate combined with remifentanil. The anesthesia indicators values, the awakening time, the postoperative pain situation and cognitive function, the levels of serum platelet activating factor (PAF) and Interferon-γ(IFN-γ), and the adverse reactions of the patients in the two groups were observed. Results: The anesthesia induction time (74.3±7.3 s), the dose of remifentanil used (183.3±22.6 μg), the time of breathing recovery (6.2±1.1 min), the extubation time (7.9±1.2 min), the time of eye opening (14.2±2.4 min) and the time of orientation recovery (13.6±2.2 min) of the patients in the observation group were significantly less than those (85.9±6.4s, 211.8±25.9 μg, 8.1±1.3 min, 11.0±2.1 min, 16.7±2.1 min and 16.7±2.4 min) of the patients in the control group. The pain score by VAS of the patients in the observation group at 3h, 6h, 12h and 24h after operation were significantly lower than those of the patients in the control group. The MMSE score of the patients in the observation group at 3h, 6h and 12h after operation (20.45±1.97 points, 24.59±2.20 points and 27.89±1.67 points) were significantly higher than those (18.46±2.05 points, 23.47±2.14 points and 27.24±1.83 points) of the patients in the control group. At 24h after operation, the PAF level of the patients in the two groups had increased significantly and the IFN-γ level of the patients in the two groups had decreased significantly, but the changes of which of the patients in the observation group were significantly less than those of the patients in the control group. The incidence of the adverse reactions (6.7%) of the patients in the observation group was significantly lower than that (22.2%) of the patients in the control group (all P<0.05). Conclusion: The combination of remazolam besylate and remifentanil used during hysteroscopic surgery of the patients has good anesthetic effect, has the advantages of the shorter induction time and faster recovery, can reduce postoperative pain of the patients, has a slight impact on the cognitive function and the serological indicators, and has fewer adverse reactions of the patients, and which it is both effective and safe.
2024 Vol. 32 (7): 1519- [Abstract]（
67
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
GUI Huajian1, WU Zhaolin2
To analyze the effects of propofol combined with dexmedetomidine used during laparoscopic myomectomy of patients on their postoperative pain and stress response. Methods: 92 patients who wanted laparoscopic myomectomy were randomly assigned to two groups from January 2021 to December 2023. 46 patients in control group received propofol combined with sufentanil for anesthesia maintenance, while 46 patients in observation group received propofol combined with dexmedetomidine for anesthesia maintenance. The postoperative pain degree evaluated by VAS score, the cognitive function evaluated by MMSE score, the levels of stress response of cortisol (Cor) and inflammatory factor of cytokine-6 (IL-6), and rates of adverse reactions, such as nausea and vomiting, hypoxemia, respiratory depression and restlessness, of the patients were compared between the two groups. Results: The VAS scores of the patients in the observation group at 2 h, 6 h, 12 h and 24 h after operation (2.91±0.52 points, 2.51±0.50 points, 2.06±0.43 points and 1.73±0.35 points) were significantly lower than those (3.59±0.60 points, 3.06±0.57 points, 2.40±0.47 points and 2.10±0.40 points) of the patients in the control group. The MMSE score of the patients in the two groups at 24 h after operation had decreased significantly, and which (27.80±1.11 points) of the patients in the observation group was significantly higher than that (26.74±1.08 points) of the patients in the control group. The serum levels of Cor and IL-6 of the patients in the two groups at 24 h after operation had increased significantly, and which (16.29±3.29 mmol/L and 78.39±6.72 pg/ml) of the patients in the observation group were significantly lower than those (20.46±3.40 mmol/L and 86.35±6.11 pg/ml) of the patients in the control group. The total incidence of adverse reactions (4.4%) of the patients in the observation group was significantly lower than that (17.4%) of the patients in the control group (all P<0.05). Conclusion: The combination of propofol and dexmedetomidine used during laparoscopic myomectomy of the patients has good anesthetic effect, which can reduce the pain degree and cognitive impairment of the patients, improve the stress response indicators and inflammatory factor levels of the patients, and has fewer adverse reactions and better medicine safety.
2024 Vol. 32 (7): 1524- [Abstract]（
60
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
YAO Qin, WU Ling, CHEN Zuqi
To analyze the anesthesia effect of low-dose esketamine used in laparoscopic uterine fibroid surgery. Methods: 102 patients who wanted laparoscopic uterine fibroids surgery were divided into study group (n=51) and control group (n=51) using a random number table method from January 2022 to December 2023. The anesthesia induction and maintenance methods of the patients in both groups were the same. The patients in the study group received intravenous injection esketamine (0.5mg/kg) before skin incision, followed by continuous intravenous infusion of 0.125mg/(kg·h) of esketamine. The patients in the control group received an equal amount of 0.9% sodium chloride injection at the same time. The anesthesia time, the surgical time, the postoperative recovery time, the extubation time, the VAS pain score at different time points, the Ramsay sedation score, the levels of stress response, such as adrenaline, norepinephrine and cortisol, and the incidence of postoperative adverse reactions of the patients in the two groups were observed and recorded. Results: The VAS scores of the patients in the study group at 6h and 12h after operation (2.01±0.22 points and 2.33±0.36 points) were significantly lower than those (3.25±0.28 points and 3.62±0.47 points) of the patients in the control group. The levels of epinephrine, norepinephrine and cortisol of the patients in the two groups at 24h after operation had increased significantly, but which (69.62±8.54 pg/ml, 198.96±23.29 pg/ml and 290.92±27.19 ng/ml) of the patients in the study group were significantly lower than those (85.52±7.63 pg/ml, 175.60±24.79 pg/ml and 320.25±28.74ng/ml) of the patients in the control group (all P<0.05). There was no significant difference in the total incidence of adverse reactions (19.6% vs. 29.4%) of the patients between the two groups (P>0.05). Conclusion: Low dose esketamine can enhance the postoperative analgesic effect, reduce the postoperative stress reactions and do not increase anesthesia related adverse reactions of the patients, which has certain safety and effectiveness.
2024 Vol. 32 (7): 1528- [Abstract]（
80
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
ZHANG Yuanyuan1, LIU Cuilan2
To explore the effect of nasal intermittent positive pressure ventilation (NIPPV) combined with less invasive surfactant administration (LISA) for treating premature infants with neonatal respiratory distress syndrome (NRDS), and to study its influence on the arterial blood gas and incidences of adverse events of the premature infants. Methods: From June 2020 to September 2023, 96 premature infants with NRDS were selected and were divided into observation group (48 cases) and control group (48 cases) according to the simple randomization grouping method. The infants in both groups were given non-invasive assisted ventilation in the neonatal intensive care unit. The infants in the control group received NCPAP treatment, while the infants in the observation group received NCPAP combined with LISA treatment. The clinical treatment status, the values of arterial blood gas indicators, such as arterial partial oxygen pressure (PaO2), arterial partial pressure of carbon dioxide (PaCO2), arterial oxygen saturation (SiO2) and PH, the values of pulmonary oxygenation indexes, such as arterial partial oxygen pressure/partial alveolar oxygen pressure (PaO2/PAO2) and oxygenation index (OI), and the incidence of adverse events of the infants were compared between the two groups. Results: After treatment, the non-invasive ventilation time (5.3±1.7d), the proportion of invasive ventilation (16.7%), the total oxygen therapy time (10.7±2.2d), and the duration of hospital stay (27.9±4.3d) of the infants in the observation group were significantly lower than those (6.6±2.0d, 35.4%, 12.4±2.5d and 31.6±5.1d) of the infants in the control group. The successful rate of stopping ventilation (87.5%) of the infants in the observation group was significantly higher than that (72.9%) of the infants in the control group. The values of PaO2, SiO2, PaO2/PAO2 and PH of the infants in the two groups after treatment had increased significantly, and the PaCO2 and OI values of the infants in the two groups after treatment had decreased significantly, and the improvement of which of the infants in the observation group were significantly greater than those of the infants in the control group. The total incidence of adverse events (8.3%) of the infants in the observation group was significantly lower than that (25.0%) of the infants in the control group (all P<0.05). Conclusion: NIPPV combined with LISA for treating the premature infants with NRDS can effectively improve their arterial blood gas, enhance their pulmonary ventilation, promote the improvement of their clinical symptoms and shorten their hospital stay.
2024 Vol. 32 (7): 1533- [Abstract]（
64
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
GUO Tingting, WU Xuhong, TANG Jueyao, LI Xiaobei
To analyze the application effect and safety of labor analgesia at different timing of primiparas with hypertensive disorder complicating pregnancy (HDP). Methods: From January 2023 and December 2023, 213 primiparas with HDP who gave birth in hospital were selected and were randomly divided into two groups. The labor analgesia begun of 71 primiparas in group A at their cervix<3cm and the labor analgesia begun of 142 primiparas in group B at their cervix ≥3cm. The delivery mode, the duration of labor, the maternal and neonatal situations and the anesthesia related adverse reactions of the primiparas were compared between the two groups. At the entry of the operation room (T0), at 30 minutes after analgesia (T1), at 2h after analgesia (T2) and at full opening of the cervix (T3), the pain degree of the primiparas in the two groups were evaluated by visual analogue scale (VAS) score and the values of heart rate (HR) and mean arterial pressure (MAP) of the primiparas in the two groups were also monitored. Results: There were no significant differences in the durations of the first, the second, the third and the total stages of labor of the primiparas between the two groups (P>0.05). The VAS scores of the primiparas in group A at T1-T3 (5.31±1.02 points, 2.81±0.33 points and 2.89±0.35 points) were significantly lower than those (6.39±1.21 points, 4.34±0.81 points and 4.41±0.82 points) of the primiparas in group B. The values of HR and MAP (91.95±6.64 beats/min and 94.24±7.32 mmHg) of the primiparas in group A at T3 were significantly lower than those (94.24±7.32 beats/min and 94.55±7.78 mmHg) of the primiparas in group B (all P<0.05). There were no significant differences in the postpartum hemorrhage volum and the adverse reactions rate of the primiparas, and the neonatal birth weight and Apgar score between the two groups (P>0.05). Conclusion: Compared with those at the active phase of the labor, the labor analgesia of the primiparas with HDP begins at the latentperiod of the labor is safe and feasible, and which can better relieve the labor pain and control the blood pressure and heart rate of the primiparas, and without affecting the labor process and the maternal and infant’s safety.
2024 Vol. 32 (7): 1538- [Abstract]（
60
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
ZHANG Huajun1, CHEN Lihui2, XIAO Fei1, YUAN Jianna1, WANG Wei1
To explore the clinical effect of vitamin D combined with insulin aspart injection (novorapid) for treating pregnant women with gestational diabetes mellitus (GDM). Methods: 114 pregnant women with GDM were selected and were divided into two groups (57 cases in each group) by the random number table method from January 2020 to January 2023. The women in the two groups were treated with insulin aspart injection continuously until the blood glucose reached the standard, while the women in the study group was given vitamin D additionally. The levels of blood glucose indicators, such as fasting plasma glucose (FPG), 2h postprandial blood glucose (2hPG), and HbA1c, the insulin indicators, such as fasting insulin (FINS) level, and the values of homeostasis model assessment (HOMA) of islet β cell function and HOMA-insulin resistance (IR), the levels of blood lipids, such as plasma fatty acid, total cholesterol and triglyceride, the levels of homocysteine (Hcy), the Toll-like receptor 4 (TLR4) and vascular cell adhesion molecule (VCAM-1) of the women before treatment and before delivery were compared between the two groups. The maternal and infant outcomes in the two groups were followed up. Results: The levels of FPG, 2hPG and HbA1c after treatment of the women in the two groups before delivery had decreased significantly (P<0.05), but which of the women had no significant difference between the two groups (P>0.05). The FINS level and the HOMA-IR value of the women in the two groups after treatment had decreased significantly, and the HOMA-β value of the women in the two groups after treatment had increased significantly, and which (12.76±1.46μU/ml, 2.98±0.23 and 89.52±8.10) of the women in the study group were significantly better than those (12.87±1.52μU/ml, 3.30±0.52 and 81.41±8.08) of the women in the control group. The blood lipid indexes levels of the women in the two groups after treatment had decreased significantly, and which of the women in the study group were significantly lower than those of the women in the control group. The levels of TLR4, VCAM-1 and Hcy of the women in the two groups after treatment had decreased significantly, and which (6.71±1.38 mU/L, 43.63±7.47 ng/ml and 8.47±1.85μmol/L) of the women in the study group were significantly lower than those (8.49±1.46 mU/L, 52.47±7.63 ng/ml and 11.21±2.76μmol/L) of the women in the control group (all P<0.05). There was no significant difference in the incidence of the adverse maternal and neonatal outcomes (14.0% vs. 8.8%) of the women between the two groups (P>0.05). Conclusion: Vitamin D supplemented with insulin aspart injection for treating the pregnant women with GDM is beneficial to improving their insulin resistance and lipid metabolism, and which can inhibit the expressions of pro-inflammatory factors, such as Hcy, of the women, and without increasing the risk of the adverse maternal and infant outcomes.
2024 Vol. 32 (7): 1542- [Abstract]（
68
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
ZHU Xiuxiu1, WANG Huilan1, JIANG Xiuchan2, QI Shihong1
To explore the effect of the electrical stimulation for treating patients with vaginal dryness, and to study its influence on the pelvic floor function of the patients. Methods: A retrospective analysis on the data of the patients with vaginal dryness who received treatment from June 2022 to June 2023 was conducted. Among them, 70 patients who received conventional drug treatment were included in group A, and 70 patients who received electrical stimulation combined with conventional treatment were included in group B. After treatment, the changes of the scores evaluated by vaginal health index score (VHIS) and sexual function index (FSFI), and the values of the pelvic floor muscle surface electromyography indexes and pelvic floor muscle strength indexes of the patients were compared between the two groups. Results: After treatment, the scores of the VHIS subitems, such as vaginal mucosa elasticity, the secretion type and viscosity, the vaginal mucosal epithelial integrity and the vaginal wetness, of the patients in the two groups had increased, and which (4.15±0.42 points, 4.31±0.49 points, 4.52±0.39 points and 4.49±0.41 points) of the patients in group B were significantly higher than those (3.26±0.36 points, 3.82±0.46 points, 3.91±0.41 points and 3.73±0.39 points) of the patients in group A. The scores of FSFI sub-items, such as the sexual desire, subjective sex arousal, the vaginal lubrication situation during sexual activity, the satisfaction with orgasm sexual life, the dyspareunia and the total score, of the patients in both groups had increased significantly, and which of the patients in group B were significantly higher than those of the patients in group A. The scores of the subitems and the total score of FSFI of the patients in both groups had decreased significantly in the pre-resting phase, in the type Ⅱ muscle testing phase and in the postresting phase, but which of the patients in both groups had increased significantly in the type Ⅰ muscle testing phase and in the endurance test phase, and the changes of the scores of the subitems and the total score of FSFI of the patients in group B were significantly greater than those of the patients in group A. The sustained systolic pressure and the contractile maintenance time of type Ⅰ and type Ⅱ muscle of the patients in the two groups had increased significantly, and which of the patients in group B were significantly higher than those of the patients in group A (all P<0.05). There was no significant difference in the adverse reactions rate (17.1% vs. 8.6%) of the patients between the two groups (P>0.05). Conclusion: Electric stimulation for treating the patients with vaginal dryness can further improve their clinical indicators, alleviate their clinical symptoms and enhance their pelvic floor function.
2024 Vol. 32 (7): 1548- [Abstract]（
92
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
SHEN Chen, ZUO Li, TIAN Yufei, LI Daoxing, ZHANG Jingchao, SHEN Xue, SUN Yan
To investigate the effects of the breast milk olfactory stimulation combined with the music intervention for the neonates with venipuncture on their analgesia and puncture success rate. Methods: 102 neonates who wanted venipuncture in hospital were selected and were divided into two groups from December 2021 to December 2023. 51 neonates in the control group were given conventional venipuncture method, and 51 neonates in the observation group were given the breast milk olfactory stimulation combined with the music intervention additionally. The scores of neonatal pain assessment scale (NIPS) and neonatal face coding system (NFCS), the onset and duration of crying, the success rate of once puncture, the values of heart rate and oxygen saturation (SpO2) and the puncture related complications rate of the neonates were compared between the two groups. Results: The NIPS scores during puncture and at 1 min and 2 min after puncture (4.83±0.74 points, 2.35±0.67 points and 0.78±0.40 points), the NFCS score (5.02±1.14 points, 3.18±0.75 points and 1.04±0.33 points), the crying duration (54.3±7.2s), the HR value during puncture and at 1 min and 2 min after puncture (148.1±4.9 times/m, 149.3±4.8 times/min and 142.1±4.2 times/min), and the incidence of puncture related complications (5.9%) of the neonates in the observation group were significantly lower than those (5.32±0.88 points, 3.49±0.56 points, 1.43±0.47 points, 5.78±1.09 points, 4.22±0.93 points, 1.51±0.4 8 points, 110.82±12.28 s, 153.8±5.2 times/min, 155.4±4.9 times/min, 146.3±4.2 times/min, and 19.6%) of the neonates in the control group. The onset time (2.8±0.4 s) of the neonatal crying in the observation group was significantly later than that (2.1±0.2 s) in the control group. The success rate of once puncture (96.1%), and the SpO2 value during puncture and at 1 min and 2 min after puncture (95.8±1.9%, 95.2±1.8% and 95.0±1.7%) of the neonates in the observation group were significantly higher than those (82.4%, 94.5±1.7%, 94.0±1.6% and 93.6±1.6%) of the neonates in the control group (all P<0.05). Conclusion: The breast milk olfactory stimulation combined with the music intervention for the neonates with venipuncture can effectively reduce their pain perception, reduce their crying time, improve their success rate of once puncture and reduce their risk of puncture related complications.
2024 Vol. 32 (7): 1553- [Abstract]（
82
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
DING Wei1, WANG Suping1,WANG Xiaojie2
To observe the effects of the perioperative intervention based on the timing theory for patients with uterine scar pregnancy surgery on their postoperative psychological state and recovery process. Methods: From June 2019 to June 2023, 96 patients with uterine scar pregnancy who wanted surgery in hospital were selected and were randomly divided into two groups (48 cases in each group) by random number table. The patients in group A were given routine nursing, and the patients in group B were given perioperative intervention based on the timing theory. The postoperative recovery process, psychological state, self-care ability, complications rate and nursing satisfaction of the patients were compared between the two groups. Results: After intervention, the recovery time of ovulation (3.8±1.0 months), the hospital stay (5.8±1.8 days) and the time of serum human chorionic gonadotropin recovery (12.2±3.9 days) of the patients in group B were significantly shorter than those (4.7±1.1 months, 7.0±2.0 days and 14.8±4.0 days) of the patients in group A. The scores of self-rating depression scale (42.59±5.38 points) and self-rating anxiety scale (43.85±4.38 points) and the incidence of postoperative complications (4.2%) of the patients in group B were significantly lower than those (49.24±5.61 points, 48.02±4.50 points and 16.7%) of the patients in group A. The scores of self-care responsibility, skills, knowledge and self-concept of the patients in group B were significantly higher than those of the patients in group A. The total nursing satisfaction (93.8%) of the patients in group B was significantly higher than that (75.5%) of the patients in group A (all P<0.05). Conclusion: The perioperative intervention based on the timing theory for the patients with uterine scar pregnancy surgery can improve their postoperative psychological state and self-care ability, accelerate their postoperative recovery process, reduce their complications occurrence and improve their nursing satisfaction.
2024 Vol. 32 (7): 1558- [Abstract]（
53
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
OU Weiwei, HU Jie, PAN Xinlan
To investigate the effects of the evidence-based practice of perioperative thermal insulation for women with cesarean section on their core body temperature and circulatory function. Methods: 92 pregnant women who wanted cesarean section were selected and were divided into two groups (46 cases in each group) by numerical odd-even method between November 2019 and November 2023. The women in the two groups were given the perioperative routine care intervention, and the women in the observation group were given the evidence-based practice of perioperative thermal insulation additionally. The perioperative core body temperature value, the circulatory function, the incidences of complications, such as agitation, chills and hypothermia, and the nursing satisfaction of the women were compared between the two groups. Results: The core temperature values of the women in the observation group at skin incision (37.10±0.19℃), at 15min of operation (36.64±0.39℃), at fetal delivery (36.31±0.35℃) and at the end of operation (36.52±0.33℃) were significantly higher than those (36.84±0.20℃, 36.12±0.41℃, 35.85±0.47℃ and 35.81±0.45℃) of the women in the control group. The change values of the heart rate, the diastolic blood pressure, the systolic blood pressure and the mean arterial pressure of the women in the observation group at 15min of operation and at the end of operation were significantly lower than those of the women in the control group. The incidences of shivering (2.2%) and hypothermia (4.4%) of the women in the observation group were significantly lower than those (13.1% and 21.7%) of the women in the control group. The nursing satisfaction (93.5%) of the women in the observation group was significantly higher than that (76.1%) of the women in the control group (all P<0.05). Conclusion: The application of the evidencebased practice of perioperative thermal insulation for the pregnant women with cesarean section can effectively maintain their perioperative core body temperature, improve their circulatory function and reduce the risk of their hypothermia and chills, and which is accepted by the women widely.
2024 Vol. 32 (7): 1563- [Abstract]（
73
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
ZHANG Jingchao, ZUO Li, TIAN Yufei, LI Daoxing, SHEN Chen, ZHEN Xue
To analyze the effects of the mother heart sound environment combined with the kangaroo mother care intervention for premature infants on their growth and development, bilirubin metabolism and cardiopulmonary function. Methods: 96 premature infants who had been treated in the hospital were selected and were divided intothe control group (48 cases with the routine nursing model) and the observation group (48 cases with the indirect mother heart sound environment combined with the kangaroo mother care intervention model) by the random number table method from January 2019 to January 2022. The bilirubin metabolism situation, the cardiopulmonary function, the sleep quality and the growth and development status of the infants, and the maternal satisfaction for the nursing were compared between the two groups. Results: The transcutaneous bilirubin value of the infants in the two groups had increased firstly and then had decreased at 24h, 72h, 120h and 168h after intervention, and which (72.35±11.21μmol/L, 123.69±12.47μmol/L, 152.36±28.69μmol/L and 86.15 ±9.12μmol/L) of the infants in the observation group were significantly lower than those (78.68±12.69μmol/L, 129.23±13.10μmol/L, 177.58 ± 35.52μmol/L and 91.14 ±11.02μmol/L) of the infants in the control group, and the transcutaneous bilirubin value of the infants in the two groups reached the peak at 120h after birth. The heart rate and respiratory rate of the infants in the two groups on the 4th and 7th day of intervention had decreased gradually, and the blood oxygen saturation value of the infants increased gradually, and the changes of which in the observation group were significantly greater than those of the infants in the
control group (all P<0.05). The number of the night awakening (4.45±0.98 times) of the infants in the observation group on the 28th day of intervention was significantly lower than that (5.38±1.03times) of the infants in the control group, and the night sleep time (10.85±1.38h) and daytime sleep time (9.24±1.25h) of the infants in the observation group on the 28th day of intervention were significantly higher than those (10.12±1.24h and 8.63±1.46h) of the infants in the control group. The values of head circumference (3.12±0.56cm), length (5.12±1.25cm) and weight (621.64±101.19g) of the infants in the observation group were significantly higher than those (2.88±0.48cm, 4.45±1.31cm and 538.55±92.14g) of the infants in the control group. The total maternal nursing satisfaction (95.8%) in the control group was significantly higher than that (83.3%) in the control group (all P<0.05). Conclusion: The mother’s heart sound environment combined with kangaroo mother care model for the premature infants can effectively reduce their bilirubin level, improve their cardiopulmonary function and sleep quality, promote their growth and development and enhance the nursing satisfaction of their family members.
2024 Vol. 32 (7): 1568- [Abstract]（
53
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
ZHAO Conghui，WANG Xiaoying，YANG Liu，ZHANG Zunzun
To study the effects of the influence of the continuous nursing based on information management platform for postpartum patients with pelvic floor dysfunction (PFD) on their muscle contractility. Methods: 115 patients with postpartum PFD who wanted treatment in hospital were selected and divided into experimental group (n=58) and control group (n=57) by random number table method from January 2020 to December 2022. The patients in both groups were given postpartum pelvic floor rehabilitation training, and the patients in the control group were given routine postnatal care and the patients in the experimental group were given continuous care based on the information management platform. The clinical efficacy, the muscle contractility, the pelvic floor fatigue value, the scores of pelvic floor distress inventory-7 (PFIQ-7) and pelvic floor distress inventory-20 (PFDI-20), and the postpartum complications rate of the patients after 3 months of treatment were compared between the two groups. Results: The total effective rate (87.9%) of the patients in the experimental group was significantly higher than that (71.9%) of the patients in the control group. The values of muscle contractility (263.71±3.58 g/cm2), the muscle electric potential (15.35±2.34μV), the static tension (184.58±36.47 g/cm2) and the dynamic tension (242.25±45.23 g/cm2) of the patients in the experimental group were significantly higher than those (224.52±46.69 g/cm2, 13.88±2.38μV, 143.52±37.96 g/cm2 and 214.58±50.17 g/cm2) of the patients in the control group. The fatigue values of the type I muscle fiber (3.30±0.34%/s) and the type II muscle fiber (3.12±0.31%/s) of the patients in the experimental group were significantly
lower than those (3.98±0.65%/s and 4.05±0.41%/s) of the patients in the control group. The scores of PFIQ-7 (12.14±3.24 points）and PFDI-20 (9.14±2.23 points), and the total incidence of pelvic floor complications (5.2%) of the patients in the experimental group were significantly lower than those (16.65±3.25 points, 12.42±4.30 points and 17.5%) of the patients in the control group (all P<0.05). Conclusion: The continuous nursing based on information management platform for the patients with postpartum PFD has better effect, and which can effectively improve their muscle contractility and quality of life.
2024 Vol. 32 (7): 1573- [Abstract]（
56
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
LIU Ping, LU Yingying
To explore the effect of the family participatory dignity therapy for intervening patients with advanced gynecological malignant tumor. Methods: From January 2021 to January 2023, a total of 102 patients with advanced gynecological malignancies were included and were divided into observation group (51 cases) and control group (51 cases) by random number table method. The routine nursing intervention was given to the patients in the two groups, and the family participatory dignity therapy was given to the patients in the observation group additionally. During the intervention, there were 3 patients with fell off in the observation group and 1 patient with fell off in the control group. The scores of the patient dignity scale (PDI), psychological pain management screening tool (DMSM), Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), cancer pain score (NRS) and quality of life scale (QLQ-C30), and the satisfaction of the patients in the two groups before and after intervention were evaluated by questionnaire. Results: After the intervention, the sores of PDI, DMSM, HAMA, HAMD, NRS and QLQ-C30 of the patients in the two groups had improved significantly, and which (49.76±5.05 points, 4.59±0.49 points, 18.34±3.11 points, 20.69±2.16 points, 3.95±0.58 points and 66.83±3.74 points) of the patients in the observation group were significantly better than those (59.73±4.21 points, 5.72±0.56 points, 22.15±3.26 points, 25.34±2.85 points, 4.95±0.76 points and 57.23±4.92 points) of the patients in the control group. The satisfaction rate (95.8%) of the patients in the observation group was significantly higher than that (82.0%) of the patients in the control group (all P<0.05). Conclusion: The family participatory dignity therapy for intervening the patients with advanced gynecological malignant tumor has positive effect, which can better improve their dignity level, relieve their psychological pain, anxiety and depression, reduce their degree of cancer pain, improve their quality of life, and with higher intervention satisfaction.
2024 Vol. 32 (7): 1578- [Abstract]（
93
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
FENG Lei1, WANG Hui1, ZHANG Mei2, MA Cuilan1
To study the effects of the human-based management intervention for patients with ovarian cyst surgery in operating room on their postoperative rehabilitation, psychological stress and treatment compliance. Methods: A total of 80 patients who wanted gynecological ovarian cyst surgery were selected and divided into two groups (40 cases in each group) according to random number method from October 2021 to March 2024. The patients in the two groups were given routine nursing for two months, and the patients in the observation group were given human-based management in operating room additionally. The situations of the postoperative rehabilitation, psychological stress, compliance and complications of the patients were compared between the two groups. Results: The time of getting out of bed (16.79±4.12h), the postoperative hospital stay (4.68±0.49d), the catheter indwelling time (8.59±2.27h) and the first exhaust time (26.15±5.35h) of the patients in the observation group were significantly shorter than those (25.64±5.49h, 5.62±0.79d, 13.34±2.84h and 35.24±7.35h) of the patients in the control group. The scores of Hamilton anxiety scale (8.16±2.19 points) and Hamilton depression scale (6.35±1.98 points) at discharge, and the incidence of complications (5.0%) of the patients in the observation group were significantly lower than those (11.63±2.54 points, 9.12±2.12 points and 17.0%) of the patients in the control group. The treatment compliance (97.5%) and the Morisky medication compliance scale score at discharge (6.15±1.24 points) of the patients in the observation group were significantly higher than those (82.5% and 6.15±1.24 points) of the patients in the control group (all P<0.05). Conclusion: Humanbased management intervention for the patients with ovarian cyst surgery in operating room is effective in their postoperative rehabilitation, psychological stress and treatment compliance, and in their reduction of postoperative complications.
2024 Vol. 32 (7): 1582- [Abstract]（
55
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
SONG Duidui, NIU Lina, ZHANG Xiaojuan, MA Ping, WEI Xiaojuan
To explore the possible influencing factors of the adverse pregnancy outcomes of patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The clinical data of 225 patients with ICP admitted to the hospital from January 2018 to January 2023 were collected. The basic information and the hematological indicators values of the patients were collected, and the patients were followed up for 12 months. Logistic regression was used to analyze the possible influencing factors of the adverse pregnancy outcomes of the patients. Receiver operating characteristic (ROC) curve was plotted to evaluate the efficacy of the influencing factors for predicting the adverse pregnancy outcomes of the patients. Results: The incidence of the adverse pregnancy outcomes of the patients with ICP was 37.8% (85/225). Logistic regression analysis showed that the abnormally increased serum glycholic acid level and the total bile acid level and the albumin/alkaline phosphatase ratio of the patients with ICP were the independent influencing factors of their adverse pregnancy outcomes. ROC curve analysis showed that the area under the curve (AUC) of the serum glycholic acid level, the total bile acid level, the albumin/alkaline phosphatase ratio, and the combined the serum glycholic acid level, the total bile acid level and the albumin/alkaline phosphatase ratio of the patients with ICP for predicting their adverse pregnancy outcomes were 0.692, 0.713, 0.689 and 0.876, respectively. Conclusion: The abnormally increased serum glycholic acid level, the total bile acid level and the albumin/alkaline phosphatase ratio of the patients with ICP are the independent influencing factors of their adverse pregnancy outcomes, and which have certain efficacy for predicting the adverse pregnancy outcomes of the patients.
2024 Vol. 32 (7): 1586- [Abstract]（
93
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
LI Cuiming, WEI Min, BAI Hua
To explore the correlation between the levels of serum anti-mullerian hormone (AMH) and Betatrophin of patients with low ovarian reserve (LOR) and their ovarian reactivity and pregnancy outcomes after in vitro fertilization-embryo transfer (IVF-ET). Methods: The clinical data of 137 patients with LOR who had undergone IVF-ET from December 2019 to December 2022 were collected in this study. These patients were divided into group A (112 patients with LOR), group B (16 patients with normal ovarian reactivity) and group C (9 patients with high ovarian reactivity) according to their ovarian reactivity. These patients also were divided into group D (44 patients with success pregnancy) and group E (93 patients with pregnancy failure) according to their pregnancy situation. Enzyme-linked immunosorbent assay was used to detect the serum AMH and Betatrophin levels of these patients. Receiver operator characteristic (ROC) curve was used to evaluate the predictive value of the serum AMH and Betatrophin levels of the patients with LOR for their pregnancy outcomes after IVF-ET. The influencing factors of the pregnancy outcomes of the patients with LOR after IVF-ET were explored by multivariate logistic regression. Results: The serum AMH level of the patients in group A (0.49±0.13 ng/ml), in group B (0.98±0.21 ng/ml) and in group C (1.05±0.26 ng/ml) had increased gradually. The serum Betatrophin level of the patients in group A (156.95±16.33 pg/ml), in group B (112.17±13.42 pg/ml) and in group C (92.64±11.03 pg/ml) had decreased gradually. The level of serum AMH level (1.07±0.36 ng/ml) of the patients in group D was significantly higher than that (0.34±0.19 ng/ml) of the patients in group E, and the level of Betatrophin (136.29±14.42 pg/ml) of the patients in group D was significantly lower than that (216.16±21.05 pg/ml) of the patients in group E (all P<0.05). The area under the curve (AUC) of the levels of serum AMH level, the Betatrophin level and the combined levels of serum AMH and Betatrophin of the patients with LOD for predicting their pregnancy outcomes after IVF-ET was 0.857, 0.771 and 0.904, respectively. Multivariate logistic regression analysis showed that the follicle-stimulating hormone/ luteinizing hormone ratio ≥2, the poor ovarian response, the AMH level ≤0.71ng/ml, and the Betatrophin level ≥176.23pg/ml of the patients with LOD were the independent risk factors of their pregnancy failure after IVF-ET (P<0.05). Conclusion: The serum AMH and Betatrophin levels of the patients with LOD are associated with their ovarian reactivity and pregnancy outcomes after IVF-ET, and both of which can be used as the potential biomarkers to predict the pregnancy outcomes of the patients after IVF-ET.
2024 Vol. 32 (7): 1591- [Abstract]（
68
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
ZHENG Xiaojie1,2，HONG Mingyun1，TANG Zhixia1
To investigate the effect of the intrauterine infusion of growth hormone for treating patients with the resistant thin endometrium, and to study the pregnancy outcomes of the freeze-thaw embryo transfer (FET) of the patients. Methods: A total of 93 patients with the resistant thin endometrium refractory thin endometrium who wanted FET in the hospital were selected and were randomly divided into two groups from January 2015 to August 2022. 41 patients in the study group were given the intrauterine infusion of growth hormone combined with the hormone replacement therapy, and 52 patients in the control group were given the hormone replacement therapy. All the patients in the two groups were prepared their endometrium with an alternative cycle before FET. The therapy effect and the pregnancy outcomes of the patients in the two groups were observed. Results: The endometrial thickness (7.69±0.71 mm) on the day of FET transformation of the patients in the study group was significantly higher than that (6.63±0.49 mm) of the patients in the control group (P<0.05). The difference value of the endometrial thickness (1.98±0.91 mm) of the patients in the study group between the day of FET transformation and the day of HCG injection in fresh cycle was significantly higher than that (0.79±0.66 mm) of the patients in the control group (P<0.05). The proportions of the type A (80.5%) and type B (14.6%) endometrial morphology, and the type I (73.2%) and type II (19.5%) endometrial blood flow of the patients in the study group had significantly different from those (51.9% and 40.4%, and 48.1% and 42.3%) of the patients in the control group (P<0.05). The rates of the clinical pregnancy rate and the live birth of the patients in the study group after FET were 41.5% and 29.3%, and which were significantly different from those (21.2% and 11.5%) of the patients in the control group (P<0.05). The biochemical pregnancy rate (26.8%) and the abortion rate (29.4%) of the patients in the study group after FET had no significant different from those (19.2% and 45.5%) of the patients in the control group (P>0.05). When the endometrial thickness of the patients on the day of FET transformation was less than 7mm, there was no significant difference in the pregnancy outcomes of the patients between the two groups. There were no significant differences in the incidences of preterm birth, placental adhesion and postpartum hemorrhage of the patients with live birth between the two groups. Conclusion: The intrauterine infusion of growth hormone for treating patients with the resistant thin endometrium has significantly therapeutic effect on promoting their endometrial growth, which can increase the pregnancy rate and improve the pregnancy outcomes of the patients.
2024 Vol. 32 (7): 1596- [Abstract]（
56
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
HE Dan, LIU Yongmei, LI Yuanyuan
To exploring the effects of the acupuncture at abdominal acupoints combined with kidney tonifying and spleen strengthening (KTSS) method for treating patients with polycystic ovarian syndrome (PCOS) on their menstrual cycle, serum Iridin level and ovarian function. Methods: 90 patients with PCOS who were admitted to the hospital were selected and were randomly divided into three groups (30 cases in each group) from March 2020 to April 2022. The patients in group A were given the treatment of ethinylestradiol cycloproterone tablets, the patients in group B were given the treatment of KTSS method, and the patients in group C were given the treatment of KTSS method combined with the acupuncture at abdominal acupoints. The menstrual cycle situation, the serum Iridin level and the ovarian function of the patients after treatment were compared among the three groups. Results: The total effective rate (96.7%) of the patients in group C was significantly higher than that (73.3%) of the patients in group A, or that (76.7%) of the patients in group B (P<0.05). The levels of luteinizing hormone (LH) and testosterone (T) of the patients in the three groups after treatment had decreased significantly, and the menstrual cycle of the patients in the three groups after treatment had shortened significantly, and which of the patients in group C were significantly lower than those of the patients in group A and in group B (P<0.05). The levels of follicle stimulating hormone (FSH) and estradiol (E2) of the patients in the three groups after treatment had increased significantly, and which of the patients in group C were significantly higher than those of the patients in group A and in group B (P<0.05). The serum irisin level of the patients in the three groups after treatment had decreased significantly, and which of the patients in group C was significantly lower than that of the patients in group A and in group B (P<0.05). The ovarian volume and the number of follicles of the patients in the three groups after treatment had decreased significantly, and which of the patients in group C were significantly lower than those of the patients in group A and in group B (P<0.05). The endometrial thickness and the pulsatility index (PI) value of the uterine artery of the patients in the three groups after treatment had increased significantly, and which of the patients in group C were significantly higher than those of the patients in group A and in group B (P<0.05). The resistance index (RI) value of the uterine artery of the patients in the three groups after treatment had decreased significantly, and which of the patients in group C was significantly lower than that of the patients in group A and in group B (P<0.05). After treatment, the patients in the three groups were followed up for 6 months, the rates of normal menstruation and pregnancy of the patients in group C were significantly higher than those of the patients in group A and in group B (P<0.05). Conclusion: The acupuncture at abdominal acupoints combined with KTSS method for treating patients with PCOS can effectively regulate their sex hormones levels, promote their menstrual cycle recovery, follicular maturation, normal ovulation and pregnancy, improve their endometrial receptivity and reduce their serum irisin level, and with remarkable effectiveness.
2024 Vol. 32 (7): 1602- [Abstract]（
61
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
LU Jiehong, ZHAO Mingyang, SONG Xuewei, JIA Fan, ShI Likun, YANG Xiumei
To observe the efficacy of leuprorelin acetate (LA) combined with high-intensity focused ultrasound (HIFU) for treating patients with adenomyosis (AM). Methods: According to the random number table method, 60 patients with AM were divided into two groups. 30 patients in the control group had received the treatment of HIFU, and 30 patients in the study group had received the treatment of LA combined with HIFU. The uterine volume, the lesion volume, the menstrual status, the ovarian function, the adverse reactions rate and the recurrence rate of AM of the patients were compared between the two groups. The levels of serum carbohydrate antigen 125 (CA125), prostaglandin 2 (PGF2α) and adiponectin of the patients in the two groups were detected. Results: The uterine volume, the lesion volume, the scores of dysmenorrheal and menstrual volume and the levels of CA125 and PGF2α of the patients in the two groups after treatment had decreased significantly (P<0.05), and which of the patients in the study group were significantly lower than those of the patients in the control group (P<0.05).The adiponectin level of the patients in the two groups after treatment had increased significantly (P<0.05), and which of the patients in the study group was significantly higher than that of the patients in the control group (P<0.05). The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) of the patients in the two groups after treatment had decreased significantly (P<0.05), and which of the patients in the study group were significantly lower than those of the patients in the control group (P<0.05). There were no significant differences in the total incidence of adverse reactions and the recurrence rate after 6 months of follow-up of the patients between the two groups (P>0.05). Conclusion: LA combined with HIFU for treating the patients with AM can alleviate their dysmenorrhea, improve their menstrual volume and ovarian function, reduce their uterine and lesion volumes, and which can regulate the serum CA125, PGF2α, and adiponectin levels of the patients, and without increasing the risk of their adverse reactions and their AM recurrence.
2024 Vol. 32 (7): 1608- [Abstract]（
78
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
WANG Shengyu1, XIE Yichang1, MA Jing2, ZHAO Bangrong2, WANG Shusong2
To investigate the correlation between the semen quality of infertile men and their reproductive hormone and adipokines levels. Methods: 155 infertile men were selected in this study, including 53 cases with BMI<24 kg/m2 in group A, 53 cases with 24≤BMI<28 kg/m2 in group B and 49 cases with BMI≥28 kg/m2 in group C. CASA was used to measure the semen parameters of these infertile men. Chemiluminescent immunoassay was used to determine the serum reproductive hormones levels, and ELISA was used to measure the levels of the serum and plasma adipokine leptin (LEP), lipocalin (ADPN) and zinc α2 glycoproteins (ZAG) of the infertile men. The correlation between the semen parameters and the reproductive hormones levels of the infertile men and their serum and plasma LEP levels was analyzed. Results: The semen volume (t=-3.239, P=0.002), the sperm motility (t=-3.449, P=0.001), the serum testosterone level (t=-5.522, P<0.001) and the ZAG level (t=-3.354, P=0.001) of the infertile men in group B were significantly lower than those of the infertile men in group A. The seminal plasma ADPN level of the 155 infertile men was negative correlation with their BMI value (r=-0.160, P<0.05), but which was positively correlated with their semen volume, sperm concentration and total sperm count (r=0.250, r=0.250, r=0.368, P<0.05). The seminal plasma ZAG level of the infertile men was negatively correlated with their BMI value, sperm concentration and total sperm count (r=-0.254, r=-0.213, r=-0.178, P<0.05). There was no correlation between the seminal adipokines level of the infertile men and their blood adipokines level. Conclusion: Obesity can affect the serum testosterone level and semen quality of the infertile men. The seminal ADPN and ZAG levels of the infertile men are closely related to their semen quality.
2024 Vol. 32 (7): 1613- [Abstract]（
63
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
WANG Wei, SONG Lu, JIN Xiaowei
To study the correlation between the umbilical artery blood flow parameters values of pregnant women with intrahepatic cholestasis during pregnancy (ICP) and their fetal distress occurrence. Methods: 101 pregnant women with ICP were selected in study group and 85 healthy pregnant women were selected in control group from March 2018 to March 2021. The women in the study group were divided into group A (women with fetal distress) and group B (women without fetal distress). The correlation between the umbilical artery blood flow parameters values of the women in these groups and their fetal distress was analyzed. Results: The values of S/D (4.23±0.35), RI (1.66±0.32) and PI (1.05±0.15) of the umbilical artery blood flow parameters of the women in the study group were significantly higher than those (3.61±0.25, 1.01±0.21 and 0.74±0.23) of the women in the control group, and which of the women in group A were significantly higher than those of the women in group B. Correlation analysis showed that the values of S/D, RI and PI of the umbilical artery blood flow of the women with ICP were positively correlated with their occurrence of fetal distress (all P<0.05). Conclusion: The umbilical artery blood flow parameters values of the pregnant women with ICP are abnormal, and are correlated with their fetal distress occurrence, and which has the clinical significance for gilding the ICP control of the pregnant women.
2024 Vol. 32 (7): 1618- [Abstract]（
78
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
ZHANG Linfeng, WANG Xiaoqian, PENG Yuanyuan
To analyze the levels changes of the serum transforming growth factor-β1 (TGF-β1), interleukin-2 (IL-2) and matrix metalloproteinase-9 (MMP-9) of the women with tubal obstructive infertility, and to study their clinical significance. Methods: A total of 60 women with tubal obstructive infertility diagnosed and treated in the hospital were selected in study group and 50 women with normal pregnancy and delivery were selected in control group from March 2022 to October 2023. The serum TGF-β1, IL-2 and MMP-9 levels of the women were measured and compared between the two groups, and the correlation among which was analyzed by Pearson correlation analysis. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of the serum TGF-β1, IL-2 and MMP-9 levels of the women for their infertility, and the influencing factors of the tubal obstructive infertility of the women were analyzed by logistic multivariate regression. Results: The preoperative levels of the serum TGF-β1 (593.79±148.23 ng/L), IL-2 (3.90±0.75 ng/L) and MMP-9 (384.88±86.87 ng/ml) of the women in the study group were significantly higher than those (239.42±113.37 ng/L, 3.09±0.84 ng/L and 178.98±80.85 ng/ml) of the women in the control group. The levels of the serum TGF-β1, IL-2 and MMP-9 of the women after surgery were significantly lower than those before surgery, the serum TGF-β1 level of the women was positively correlated with their serum IL-2 and MMP-9 levels, and the serum IL-2 level of the women was positively correlated with their serum MMP-9 level (all P<0.05). ROC curve analysis showed that the area under curve (AUC), the sensitivity and the specificity of the TGF-β1 level of the women for diagnosing their infertility were 0.941, 88.3% and 94.0%, respectively, which of the IL-2 level of the women for diagnosing their infertility were 0.778, 66.7% and 84.0%, respectively, which of the MMP-9 level of the women for diagnosing their infertility were0.946, 88.3% and 86.0%, respectively, and which of the combined levels of the serum TGF-β1, IL-2 and MMP-9 of the women for diagnosing their infertility were 0.992, 93.3% and 100.0%, respectively. Logistic regression analysis showed that the abnormal increasing serum TGF-β1, IL-2 and MMP-9 levels of the women were the risk factors of the infertility caused by fallopian tube obstruction of the women (all P<0.05). Conclusion: The levels of the serum TGF-β1, IL-2 and MMP-9 of the infertility women caused by fallopian tube obstruction are highly expressed, which are the risk factors of their infertility. The combined detections of the serum TGF-β1, IL-2 and MMP-9 of the women for diagnosing their infertility has high value for their tubal obstructive infertility.
2024 Vol. 32 (7): 1621- [Abstract]（
66
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
PU Xuemei1, WANG Jiao2
To explore the correlation between the serum homocysteine (Hcy) and anti-Mullerian hormone (AMH) levels of infertility women with polycystic ovary syndrome (PCOS) and their clinical indicators. Methods: A total of 102 infertile women with PCOS were selected in observation group and 124 healthy women who underwent physical examination were selected in control group from November 2022 to November 2023. The serum Hcy level of the women in the two groups was detected by enzyme cycle method, and the serum AMH level of the women in the two groups was detected by magnetic particle luminescence method. Pearson correlation analysis was used to investigate the correlation between the serum Hcy and AMH levels of the infertile women with PCOS and their clinical indicators. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic values of the serum Hcy and AMH levels of the infertility women for their PCOS. Results: The levels of serum Hcy (19.26±2.87μmol/L) and AMH (9.27±1.86ng/ml) of the women in the observation group were significantly higher than those (11.83±2.14μmol/L and 5.13±1.14ng/ml) of the women in the control group. The C-reactive protein (3.74 ±0.51 mg/L) level and the homeostasis model assessment of insulin resistance (HOMA-IR) value (4.15±0.82) and the luteinizing hormone (LH) level (16.44±2.75 U/L) of the women in the observation group were significantly higher than those (1.16±0.23 mg/L, 2.04±0.37 and 5.47±1.36 U/L) of the women in the control group. The levels of progesterone (0.76±0.23 ng/ml) and estradiol (71.04±8.26 pg/ml) of the women in the observation group were significantly lower than those (1.64±0.52 ng/ml and 81.32±9.58 pg/ml) of the women in the control group (all P<0.05). Pearson correlation analysis showed that the serum Hcy and AMH levels of the women with PCOS were positively correlated with their CRP level, HOMA-IR value and LH level, and were negatively correlated with their progesterone and estradiol levels (all P<0.05). The values of area under the curve (AUC) and its 95%CI of the serum Hcy and AMH levels of the infertility women for diagnosing their PCOS were 0.761 (0.750-0.812) and 0.867 (0.816-0.918). The AUC (95%CI) of the combination of the serum Hcy and AMH levels of the infertility women for diagnosing their PCOS was 0.904 (0.853-0.955). Conclusion: The abnormally elevated levels of the serum Hcy and AMH of the infertility women with PCOS are associated with their inflammatory response, glucose metabolism disorder and sex hormone levels, and the levels of the serum Hcy and AMH of the infertility women has better diagnostic efficacy for their PCOS.
2024 Vol. 32 (7): 1626- [Abstract]（
73
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
GAO Yuan, WANG Xiaoyan, CUI Ying, GAO Aimei
To explore the application value of the levels of serum pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) of pregnant women during the first trimester of pregnancy for evaluating their preeclampsia (PE). Methods: The clinical data of 80 pregnant women with PE in study group who were registered in hospital during the first trimester of pregnancy and treated until delivery from October 2018 to November 2021 were analyzed retrospectively. The women in the study group were divided 35 women with severe PE in group A and 45 women with mild PE in group B. The clinical data of 84 healthy pregnant women who had pregnancy examination and were followed up until delivery in control group during the same period were also analyzed retrospectively. The levels of serum PAPP-A and PlGF and the urine protein value (24h urine protein) during the first trimester of pregnancy (11-13 gestational weeks), and the values of blood pressure (systolic blood pressure and diastolic blood pressure) during the third trimester of pregnancy of the women were compared among these groups. Pearson correlation coefficient was used to analyze the correlation between the levels of serum PAPP-A and PlGF of the women during the first trimester of pregnancy and their urine protein value (24h urine protein) during the first trimester of pregnancy and the values of blood pressure (systolic blood pressure and diastolic blood pressure) during the third trimester of pregnancy. The predictive efficacy of the serum PAPP-A and PlGF levels during the first trimester of pregnancy of the women for their PE was analyzed by receiver operating characteristic (ROC) curve. Results: The levels of serum PAPP-A (25.91±2.64 ng/ml) and PlGF (18.07±2.93μg/L) of the women in the study group were significantly lower than those (28.15±3.42 ng/ml and 21.77±4.35μg/L) of the women in the control group. The 24h urine protein quantification level and the values of the systolic blood pressure and diastolic blood pressure of the women in the study group were significantly higher than those of the women in the control group. The levels of serum PAPP-A and PLGF of the women in group A were significantly lower than those of the women in group B (all P<0.05). Correlation analysis showed that the serum PAPP-A and PlGF levels of the women with PE were negatively correlated with their 24-hour urinary protein quantitative level and systolic blood pressure and diastolic blood pressure values. ROC curve analysis showed that the sensitivity, the specificity and the area under the curve (AUC) of the PAPP-A level of the pregnant women during the first trimester of pregnancy for predicting their PE occurrence were 74.3%, 66.7% and 0.676, respectively. The sensitivity, the specificity and the AUC of the PlGF level of the pregnant women during the first trimester of pregnancy for predicting their PE occurrence were 60.0%, 68.9% and 0.671, respectively (P<0.05). Conclusion: The levels of PAPP-A and PlGF of the pregnant women with PE during the first trimester of pregnancy are lower than those of the healthy pregnant women, and which of the women decrease with their PE severity. The levels of PAPP-A and PlGF of the pregnant women during the first trimester of pregnancy have certain predictive values for their PE occurrence.
2024 Vol. 32 (7): 1630- [Abstract]（
68
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
LIU Yuping, ZHANG Zhen, WANG Yu, CHANG Juanjuan, WANG Guangming
To analyze the predictive effect Prediction effect of the prognostic nutrition index (PNI) value for the acute radiation enteritis of patients with cervical cancer and radiotherapy. Methods: The clinical data of 80 patients with cervical cancer admitted to the hospital from January 2020 to August 2023 were included in this study. According to the occurrence of the acute radiation enteritis after radiotherapy, these patients were divided into group A (patients with acute radiation enteritis) and group B (patients without acute radiation enteritis). The clinical data, such as the pathological classification, the clinical stage of cervical cancer and the PNI value of the patients were compared between the two groups. Logistic multivariate model was used to analyze the related factors affecting the occurrence of the acute radiation enteritis of the patients. Receiver operating characteristic (ROC) curve was used to analyze the efficacy of the PNI value of the patients for predicting the occurrence of their acute radiation enteritis. Results: Among 80 patients, there were 17 patients with acute radiation enteritis, with an incidence of 21.3%. The clinical symptoms of the patients were mainly the grade 1-2 diarrhea and the grade 1-2 abdominal pain. Logistic multivariate regression analysis showed that the body mass index (BMI) <18.5 kg/m2, the FIGO stage III-IV, the lymph node metastasis, the hemoglobin (Hb) <110 g/L, and the PNI value <48.84 of the patients were all the independent risk factors affecting the occurrence of their acute radiation enteritis (P<0.05). ROC curve showed that the area under the curve (AUC), the sensitivity and the specificity of the PNI value of the patients for predicting their acute radiation enteritis were 0.875, 88.3% and 87.3%, respectively. Conclusion: The PNI value of the patients with cervical cancer and radiotherapy can provide a reliable reference for predicting their acute radiation enteritis occurrence.
2024 Vol. 32 (7): 1635- [Abstract]（
81
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
LIANG Chen1，HU Qianqian2, CHEN Qian2
To study the risk factors of the severe hemorrhage during labor induction of pregnant women with pregnancy-induced hypertension (PIH). Methods: The clinical data of 200 pregnant women with PIH who had been given labor induction from January 2020 to December 2022 were selected in this study. According to the situation of the hemorrhage during labor induction, these women were divided into 34 women with severe hemorrhage (Hb decreased by 40g/L) in group A and 166 women without severe hemorrhage in group B. The risk factors of the severe hemorrhage of the women with PID during labor induction were analyzed. Results: By univariate analysis, there were no significant differences in the age, the body mass index (BMI) value, the history of delivery, the early-onset preeclampsia, the Hb level at admission, the history of induced labor or abortion, the gestational weeks at delivery, the mode of labor induction, the malnutrition rate, the number of deliveries and the values of systolic blood pressure and diastolic blood pressure of the women between the two groups (P>0.05). There were significant differences in the mode of delivery, the application of oxytocin during delivery, the time from induction to delivery and the weight of the newborn of the women between the two groups (P<0.05). Multivariate unconditional logistic analysis showed that the cesarean section, the reduced oxytocin used during labor, the longer time from induction to delivery, the higher neonatal weight and the cesarean section history of the women with PIH were all the independent risk factors of their severe hemorrhage during induced labor (P<0.05). Conclusion: There are many independent risk factors of the severe postpartum hemorrhage of the pregnant women with PIH, so the effective interventions should focus on these risk factors for the women with PIH in clinic.
2024 Vol. 32 (7): 1640- [Abstract]（
71
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
WU Yuwen, XU Haijuan, WU Wei
To explore the value of the levels of hemoglobin (Hb), D-dimer (D-D) and fibrinogen (Fib)in peripheral blood, and lymphocyte/monocyte ratio (LMR) value of pregnant women with hypertensive disorder complicating pregnancy (PIH) for predicting their severity of PIH and adverse pregnancy outcomes. Methods: 107 pregnant women with PIH from July 2019 to September 2022 were collected in study group retrospectively, including 30 women with gestational hypertension in group A, 40 women with mild preeclampsia in group B and 37 women with severe preeclampsia in group C. In addition, 50 healthy pregnant women who underwent physical examinations during the same period were selected in control group. The differences of the levels of Hb, Fig and D-D, and the LMR value of the women in these groups were analyzed. Receiver operating characteristic (ROC) curve was used to analyze the value of the levels of Hb, Fig and D-D, and the LMR value of the women with PIH for predicting their adverse pregnancy outcomes. Results: The levels of Hb, Fib and D-D, and the LMR value of the women in the study group were significantly higher than those of the women in the control group, and which of the women in group A, in group B and in group C had increased gradually (all P<0.05). Spearman correlation analysis showed that the levels of Hb, Fib and D-D, and the LMR value of the women with PIH were positively correlated with the severity of their PIH (r=0.426, 0.528, 0.388, 0.719, all P<0.05). The incidence of the adverse pregnancy outcomes of the women with PIH increased with the severity of their PIH (P<0.05). ROC curve analysis showed that the areas under the curve of the Hb level, the Fib level, the D-D level, the LMR value, and the combined levels of Hb, Fib and D-D, and the LMR value of the women with PIH for evaluating their adverse pregnancy outcomes were 0.811, 0.890, 0.711, 0.633 and 0.951, respectively. Conclusion: The levels of Hb, Fib and D-D, and the LMR value of the women with PIH are positively correlated with the severity of their PIH, and which have adverse effects on the pregnancy outcomes of the women. The combined levels of Hb, Fib and D-D, and the LMR value of the women with PIH for evaluating their adverse pregnancy outcomes has certain clinical value.
2024 Vol. 32 (7): 1644- [Abstract]（
67
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
XIE Juanjuan, JI Xuelei, SUN Chao, LI Li
To explore the predictive factors of neonates with hypoglycemia delivered by the pregnant women with gestational diabetes mellitus (GDM), and to put forward the preventive measures accordingly. Methods: The clinical data of 122 pregnant women with GDM and their neonates admitted to the hospital from January 2020 to January 2023 were analyzed retrospectively. According to whether the neonates had hypoglycemia, there were 26 women with neonatal hypoglycemia and 96 women without neonatal hypoglycemia. Univariate analysis and logistic multivariate regression model were used to explore the influencing factors of the neonatal hypoglycemia of the pregnant women with GDM. The regression prediction model was established, and its predictive power was evaluated. Results: In 122 pregnant women with GDM, there were 26 women with neonatal hypoglycemia within 48 h after birth, with the incidence of 21.3%. Multivariate analysis showed that poor blood glucose control of the women during pregnancy, the neonatal premature delivery and low birth weight, the time ≥30 minutes from the neonatal birth to the first feeding and the neonatal hyperbilirubinemia were the independent risk factors of the hypoglycemia occurrence of the neonates delivered by the women with GDM, and the regular prenatal care during pregnancy of the women with GDM was an independent protective factor for their neonatal hypoglycemia occurrence (all P<0.05). The regression prediction model established based on the above factors had a high goodness of fit. Receiver operating characteristic (ROC) curve analysis showed that the area under the curve, the sensitivity, the specificity and the accuracy of this model for predicting the hypoglycemia occurrence of the neonates delivered by pregnant women with GDM were 0.866, 61.5%, 94.8% and 87.7%, respectively. Conclusion: The poor blood glucose control during pregnancy, the neonatal premature birth and low birth weight, the time ≥30 minutes from the neonatal birth to the first feeding, the neonatal hyperbilirubinemia and the nonregular prenatal examination during pregnancy of the pregnant women with GDM are all the influencing factors of their neonatal hypoglycemia occurrence, and the prediction model constructed based on these influencing factors has the good predictive efficacy.
2024 Vol. 32 (7): 1648- [Abstract]（
73
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
YANG Shanshan，SUN Guixia，ZHANG Yanxia
To evaluate the predictive value of the levels of placental alpha 1-microglobulin (PAMG-1) and fetal fibronectin (fFN) in the cervical discharge of pregnant women for their spontaneous preterm labor. Methods: The clinical data of 128 pregnant women with spontaneous preterm labor (in study group) from April 2021 to April 2023 were collected, and another 128 normal pregnant women who underwent antenatal examination and delivered at full term were included in control group during the same period. The clinical data and the levels of PAMG-1 and fFN in the cervical discharge of the women were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the PAMG-1 and fFN levels of the pregnant women for their spontaneous preterm labor. Results: The predictive accuracy, the positive predictive value and the negative predictive value of the PAMG-1 level of the women for predicting their spontaneous preterm labor were 68.0%, 76.1% and 63.7%, respectively, and which of the fFN level of the women for predicting their spontaneous preterm labor were 67.6%, 73.2% and 64.2%, respectively. The accuracy and the positive predictive value of the combined PAMG-1 and fFN levels of the women for predicting their spontaneous preterm labor were 69.9% and 79.3%, and which were significantly higher than those of the PAMG-1 level and the fFN level (P<0.05). ROC curve analysis showed that the area under the curve, the sensitivity and the specificity of the PAMG-1 level of the women for predicting their spontaneous preterm labor were 0.680, 52.3% and 83.6%, respectively, which of the fFN level of the women for predicting their spontaneous preterm labor were 0.679, 55.5% and 79.7%, respectively, and which of the combined PAMG-1 and fFN levels of the women for predicting their spontaneous preterm labor were 0.699, 53.9% and 85.9%, respectively. Conclusion: The PAMG-1 and fFN levels in the cervical discharge of the pregnant women can be used as the predictors for their spontaneous preterm labor, and the combined PAMG-1 and fFN levels of the women has higher predictive efficiency.
2024 Vol. 32 (7): 1653- [Abstract]（
84
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
ZHENG Jingjing, ZHANG Fan, QIN Jingjing, LIU Xinyu, XIN Demei
To explore the predictive value of the vaginal microecological imbalance combined with the serum human leukocyte antigen-G (HLA-G) and human leukocyte antigen (HLA-E) levels of patients with cervical high-grade squamous intraepithelial lesion (HSIL) after cold knife conization (CKC) for their persistent human papillomavirus (HPV) infection. Methods: The clinical data of 137 patients with HSIL admitted to the hospital from January 2021 to December 2022 were collected retrospectively. These patients were treated with CKC and were followed up for 1 year after CKC. The HPV persistent infection of these patients after CKC was observed. The vaginal microecology and the serum HLA-G and HLA-E levels of the patients were measured. The correlation between the vaginal microecology and the serum HLA-G and HLA-E levels of the patients and their cervix HPV persistent infection was analyzed. The value of the vaginal microecology and the serum HLA-G and HLA-E levels of the patients for predicting their HPV persistent infection were evaluated. Results: There were 31 patients with the persistent HPV infection (in group A) and 106 cases without the persistent HPV infection (in group B) in 137 patients. There were significant
differences in the vaginal pH value, the density and diversity of the vaginal flora and the rate of trichomonas vaginitis of the patients between the two groups. The vaginal microecological imbalance rate of the patients in group A was significantly higher than that of the patients in group B. The levels of the serum HLAG (19.84±3.53 ng/ml) and HLA-E (75.39±15.83 pg/ml) of the patients in group A were significantly higher than those (16.93±2.96 ng/ml and 68.42±12.51 pg/ml) of the patients in group B. In group A, the levels of serum HLA-G and HLA-E of the patients with vaginal microecological imbalance were significantly higher than those of the patients with normal vaginal microecology (all P<0.05). Spearman correlation analysis showed that the vaginal microecological imbalance and the serum HLA-G and HLA-E levels of the patients were positively correlated with their postoperative persistent HPV infection (r=0.633, 0.529, 0.608, all P<0.05). Receiver operating characteristic curve analysis showed that the area under the curve of the vaginal microecological imbalance, the serum HLA-G level, the HLA-E level, and the combined vaginal microecological imbalance and the serum HLA-G and HLA-E levels of the patients for evaluating their postoperative persistent HPV infection were 0.601, 0.773, 0.805 and 0.885, respectively (P<0.05). Conclusion: The vaginal microecological imbalance combined with the serum HLA-G and HLA-E levels of the patients with HSIL after CKC has certain predictive value for their postoperative HPV persistent infection.
2024 Vol. 32 (7): 1658- [Abstract]（
75
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
WANG Hongyan, XU Zhiwen, SUN Xiaodong, ZHU Xiumin, CUI Yuanri
To investigate the expressions and clinical significances of the vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor (HIF)-1α in placental tissue of pregnant women with fetal growth restriction (FGR). Methods: From May 2020 to September 2022, 116 pregnant women diagnosed with FGR and hospitalized for delivery in the hospital were selected in study group. Another 116 healthy pregnant women who gave birth in the hospital were included in control group. QRT-PCR was applied to detect the mRNA expressions of VEGFA and HIF-1α in placental tissue of the women in the two groups. Immunohistochemistry was applied to detect the protein expressions of VEGFA and HIF-1α. Pearson correlation was applied to analyze the correlation between the VEGFA level of the women and their HIF-1αlevel and the correlation between the VEGFA and HIF-1αlevels of the women with FGR and their clinical data. Multivariate logistic regression was applied to analyze the factors affecting the FGR occurrence of the women. Results: The positive expression rate (25.9%) of the VEGFA protein of the women in the study group was significantly lower than that (64.7%) of the women in the control group, and the positive expression rate (67.2%) of the HIF-1α protein of the women in the study group was significantly higher than that (24.1%) of the women in the control group. The VEGFA mRNA expression level (0.75±0.20) in the placenta tissue of the women in the study group was significantly lower than that (1.00±0.23) of the women in the control group and the HIF-1αmRNA expression level (1.26±0.25) in the placenta tissue of the women in the study group was significantly higher than that (1.01±0.19) of the women in the control group (all P<0.05). The VEGFA mRNA level in placental tissues of the women with FGR was negative correlation with their HIF-1α mRNA level (P<0.05). The neonatal Apgar score at 1 min after birth, the placental weight, the placental volume and weight of the women with FGR were positively correlated with the expression level of their VEGFA, and were negatively correlated with the expression level of their HIF-1α. The increased HIF1αlevel of the women was a risk factor of their FGR occurrence, and the increased VEGFA level of the women was a protective factor of their FGR occurrence (all P<0.05). Conclusion: The VEGFA expression level in the placental tissue of the pregnant women with FGR is low and their HIF-1α expression level in the placental tissue is high, and both of which of the women affect their FGR occurrence and neonatal birth quality.
2024 Vol. 32 (7): 1663- [Abstract]（
65
）
HTML
(0 KB)
PDF
(0 KB)
(
9
)
-
QIU Zhouqun, MIN Min, LI Rong, HUANG Jiulang, HE Xue
To explore the levels of serum interleukin (IL)-6, IL-17 and IL-23 of pregnant women with hepatitis B surface antigen (HBsAg) positive and their neonates, and to study their correlation with the neonatal hepatitis B virus (HBV) intrauterine infection. Methods: The clinical data of 140 pregnant women with HBsAg positive (in study group) between January 2021 and December 2023 were collected retrospectively. According to the detection results of the HBsAg in the neonatal cord blood, the pregnant women in the study group were divided into group A (28 women with neonatal HBV intrauterine infection) and group B (112 women without neonatal HBV intrauterine infection). Another 140 pregnant women with HBsAg negative were enrolled in control group during the same period. The levels of serum IL-6, IL-17 and IL-23 in peripheral blood of the women and in neonatal cord blood serum were compared among these groups. Receiver operating characteristic (ROC) curve analysis was used to analyze the clinical value of the serum IL-6, IL-17 and IL-23 levels of the pregnant women with HBsAg positive for evaluating their neonatal HBV intrauterine infection. Results: The levels of the serum IL-6 (104.33±24.92 ng/L), IL-17 (282.65±76.71 ng/L) and IL-23 (269.52±64.28 ng/L) of the women in group A were significantly higher than those (70.34±18.61 ng/L, 123.41±43.02 ng/L and 113.75±41.68 ng/L) of the women in group B and those (68.13±17.18 ng/L, 119.53±37.13 ng/L and 110.32±44.43 ng/L) of the women in the control group (all P<0.05). There were no significant differences in the the serum IL-6, IL-17 and IL-23 levels of the women between group B and the control group (P>0.05). There were no significant differences in the IL-6, IL-17 and IL-23 levels in umbilical cord of the neonates among the three groups (P>0.05). ROC curve analysis showed that the area under the curve of the serum IL-6 level, the IL-17 level and the IL-23 level of the pregnant women with HBsAg-positive for evaluating their neonatal HBV intrauterine infection were 0.791, 0.725 and 0.745, respectively, the sensitivity and specificity of which were 61.6%-78.6%, and all of which had certain clinical reference values for evaluating their neonatal HBV intrauterine infection. Conclusion: The levels of serum IL-6, IL-17 and IL-23 of the pregnant women with the neonatal HBV intrauterine infection increase, and all of which have certain clinical guiding value for evaluating the risk of the neonatal HBV intrauterine infection of the women.
2024 Vol. 32 (7): 1668- [Abstract]（
61
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
XIANG Liming1, LIU Shumei2, ZHOU Yang2, YUAN Changyong2
To investigate the values changes of the coagulation parameters combined with the elastography (TEG) of pregnant women with gestational thrombocytopenia (GT), and to study their predictive value for the delivery outcomes of the women. Methods: The clinical data of 110 pregnant women who had delivered in the hospital from January 2020 to December 2023 were collected in this study. The occurrence of the GT of the women was determined according to their platelet count (PLT), and these were women divided into group A (58 women with GT and the PLT value <100×109/L) and group B (52 women without GT and the PLT value ≥100×109/L). The values of the coagulation indexes and TEG parameters of the women were compared between the two groups. Spearman correlation coefficient was used to analyze the correlation between the levels of the prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and the TEG parameters of the women and the incidence of their GT. The women in group A were divided into group A1 (women with the normal delivery outcomes) and group A2 (women with the poor delivery outcomes), and the values of the coagulation indexes and TEG parameters of the women were compared between the two groups. ROC curve was drawn to analyze the clinical values of the coagulation indexes and TEG parameters values of the women with GT in group A for diagnosing their delivery outcomes. Results: There were no significantly differences in the PT, APTT, TT and FIB levels of the women were compared between the group A and group B (P>0.05). The blood clot formation rate (Angle), the maximum amplitude of blood clots (MA) and the coagulation index (CI) value of the women in group A were all significantly lower than those of the women in group B. The incidence of GT of the women was no correlated with their PT, APTT, TT and FIB levels, while which was negatively correlated with their Angle, MA and CI value (all P<0.05). There were no significant differences in the PT, APTT, TT and FIB levels of the women between group A2 and group A1 (P>0.05). The Angle, MA and CI value of the women in group A2 were significantly lower than those of the women in group A1 (P<0.05). The area under the curve, the sensitivity and the specificity of the blood coagulation indexes levels combined with the TEG parameters values of the women with GT for diagnosing their delivery outcomes were 0.916, 92.3% and 93.8%, respectively, and which were significantly higher than those of the blood coagulation indexes values or the TEG parameters values (all P<0.05). Conclusion: There are no significant changes in the routine coagulation indexes of the pregnant women with GT, indicating that GT have no obvious impact on their coagulation function index. While, the values of TEG parameters of the pregnant women with GT are decreased abnormally. The blood coagulation indexes levels combined with the TEG parameters values of the women with GT for predicting their delivery outcomes can increase the predictive efficacy.
2024 Vol. 32 (7): 1673- [Abstract]（
69
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
YU Miao1, ZHANG Ying1, HUANG Siwei2, SHAN Di2
To explore the predictive value of the combined detections of prenatal serum brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and D-dimer of pregnant women for their pulmonary embolism occurrence. Methods: The clinical data of 35 pregnant women with pulmonary embolism (in study group) and 50 pregnant women without pulmonary embolism (in control group) who underwent prenatal examinations in the hospital from September 2018 to September 2023 were collected. Multivariate logistic regression was used to analyze the influencing factors of the pulmonary embolism occurrence of the pregnant women. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the prenatal serum BNP, cTnI and D-dimer levels of the women for their pulmonary embolism occurrence. Results: The levels of serum BNP (110.36±14.52 pg/ml), cTnI (0.73±0.29 ng/ml) and D-dimer (2.81±0.29μg/ml) of the women in the study group were significantly higher than those (89.72±11.87 pg/ml, 0.44±0.07 ng/ml and 2.46±0.25μg/ml) of the women in the control group. The abnormal increase serum BNP, cTnI and D-dimer levels of the women were all the independent risk factors of their pulmonary embolism occurrence. The areas under the curve of the prenatal serum BNP level, the cTnI level, the D-dimer level and the combined prenatal serum BNP, cTnI, D-dimer levels of the women for predicting their pulmonary embolism occurrence were 0.857, 0.851, 0.858, 0.921, respectively, and the combined prenatal serum BNP, cTnI, D-dimer levels of the women had the highest prediction efficiency (all P<0.05). Conclusion: The levels of prenatal serum BNP, cTnI, and D-dimer of the pregnant
women with pulmonary embolism are up-regulation, and all of which are the independent risk factors of their pulmonary embolism occurrence. The combined prenatal serum BNP, cTnI, D-dimer levels of the women has higher prediction value for the pulmonary embolism occurrence of the women.
2024 Vol. 32 (7): 1677- [Abstract]（
58
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
MAO Jianna, WEI Xiaojuan, DUAN Hualing, GAO Qi
To explore the influencing factors of the complications of pregnant women with acute fatty liver during pregnancy (AFLP). Methods: The clinical data of 153 pregnant women with AFLP admitted to the hospital from January 2020 to October 2023 were collected retrospectively. The basic information, the hematology indexes values and the score of acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) of the women were collected. The women with cesarean section were followed up for 6 months after surgery. Proportional risk model was used to analyze the factors affecting the complications of the pregnant women with AFLP. Receiver operating characteristic (ROC) curve was drawn to evaluate the efficacy of these influencing factors for predicting the complications of the women with AFLP. Results: The incidence of the postoperative complications of the women with AFLP was 23.5% (36/153). Multiariable regression analysis showed that the time from AFLP onset to visiting the hospital, the total bilirubin value, and the increased prothrombin time and APACHE Ⅱ score of the women were all the independent factors affecting their complications. ROC curve analysis showed that the time of AFLP onset to visiting the hospital (AUC=0.712), the total bilirubin value (AUC=0.741), the prothrombin time (AUC=0.734), the APACHEⅡ score (AUC=0.758), and the combination of the time from AFLP onset to visiting the hospital, the total bilirubin value and the increase of prothrombin time and APACHE Ⅱ score (AUC=0.906) of the women with AFLP had certain efficacy for predicting their complications. Conclusion: The longer time from AFLP onset to visiting the hospital, the high value of total bilirubin, and the increased prothrombin time and APACHE Ⅱ score of the women with AFLP are all the independent influencing factors of their complications, and all of these four influencing factors have certain efficacy for predicting the complications of the pregnant women with AFLP.
2024 Vol. 32 (7): 1682- [Abstract]（
70
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
HE Shuoqing, HONG Lishuan, WU Yongmei, SUN Yue’e
To explore the value of the prenatal serum immunoglobulin G (IgG) Anti A (B) antibody titer score of pregnant women with type O blood for evaluating the occurrence of the hemolytic disease of their newborn (HDN). Methods: The clinical data of 101 pregnant women with type O blood who had admitted to the hospital from January 2022 to December 2023 were selected retrospectively, and these women were divided into group A (26 women with HDN) and group B (75 women without HDN) according to the presence or absence of their HDN. The clinical data and the prenatal titer score of the serum IgG anti-A (B) antibody of the women were compared between the two groups. Spreaman correlation analysis was utilized to discuss the correlation between the prenatal titer score of the serum IgG anti-A (B) antibody of the pregnant women and the occurrence of their HDN. The predictive value of the prenatal titer score of the serum IgG anti-A (B) antibody of the women with type O blood for predicting the occurrence of their HDN was evaluated by receiver operating characteristic (ROC) curve. Results: The prenatal serum IgG anti-A (B) antibody titer of the women in group A was significantly higher than that of the women in group B. When the prenatal serum IgG anti-A (B) antibody titer of the women in the two groups was the same, the serum IgG anti-A (B) antibody titer score of the women in group A was significantly higher than that of the women in group B (all P<0.05). Spearman correlation analysis showed that the prenatal serum IgG anti-A (B) antibody titer score of the women with type O blood was positively correlated with the occurrence of their HDN (r=0.666, P<0.001). ROC curve analysis showed that the area under curve, the cutoff value, the sensitivity and the specificity of the prenatal serum IgG anti-A (B) antibody titer score of the women with type O blood for predicting the occurrence of their HDN were 0.874, 54.88, 94.7% and 84.0%, respectively. Conclusion: The prenatal serum IgG anti-A (B) antibody titer score of the women with type O blood is positive correlation with the probability of their HDN occurrence, and which has certain predictive value for the occurrence of the HDN.
2024 Vol. 32 (7): 1687- [Abstract]（
60
）
HTML
(0 KB)
PDF
(0 KB)
(
6
)
-
ZHANG Lirong1，LIN Ai1，ZHAO Zhiyong1，ZHANG Xueyou2
To explore the clinical characteristics of the necrotizing enterocolitis (NEC) of neonates with different gestational weeks, and to study its influencing factors of NEC occurrence. Methods: 368 neonates with NEC who were born and treated in the hospital between September 2019 and October 2023 were selected in study group, and 736 healthy neonates who born in the hospital during the same period were selected in control group. According to the gestational age of the newborns in the study group, the neonates were divided into group A (premature infants with <37 gestational weeks) and group B (full-term infants with ≥37 gestational weeks). The basic information, the clinical manifestations, and the major complications of the neonates in these groups were recorded. The influencing factors of NEC occurrence of the neonates were analyzed. Results: In the study group, there were 295 (80.2%) premature infants and 73 (19.8%) full-term infants. The main clinical manifestations of the neonates with NEC were the abdominal distension, the hematochezia, the vomiting and the weakened bowel sounds. The rates of the clinical manifestations, such as the abdominal distension, the weakened bowel sounds, the weakened muscle tension, the intestinal perforation and the abdominal wall vein exposure of the neonates in group B were significantly less than those of the neonates in group A. The rates of the hematochezia and the vomiting of the neonates in group B were significantly higher than those of the neonates in group A (all P<0.05). Multivariate logistic regression analysis showed that the intrahepatic cholestasis of pregnancy and the transfusion of rich red blood cells of the women were the risk factors of the NEC occurrence of their preterm infants, and the breast feeding was a protective factor of the NEC occurrence of their preterm infants. The gestational diabetes mellitus, the neonatal infection and the amniotic fluid contamination of the women were the independent risk factors of the NEC occurrence of their full-term infants. The neonatal asphyxia, the respiratory failure, the sepsis and the congenital heart disease of the neonates were the independent risk factors of their NEC occurrence, and the prophylactic probiotics used of the neonates was a protective factor of their NEC occurrence (all P<0.05). Conclusion: NEC is more common in the premature infants, and with the abdominal distension, the bloody stools, the vomiting and the weakened bowel sounds as the main clinical manifestations. The incidence factors of the NEC of the neonates with different gestational weeks are different, while the prophylactic probiotics used of the neonates can reduce the risk of their NEC occurrence, and the breastfeeding is beneficial for avoiding the occurrence of NEC of the premature infants.
2024 Vol. 32 (7): 1692- [Abstract]（
58
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
YANG Huixin, WEI Shuyan, WEN Xiaoyan
To analyze the karyotype distribution, pregnancy outcomes, and postnatal phenotype of fetuses with sex chromosome aneuploidy (SCA). Methods: A total of 11063 pregnant women who underwent amniocentesis for prenatal diagnosis in the hospital from July 2011 to April 2022 were enrolled in this study. The prenatal diagnostic indications of these women included the advanced age, the high risk of the fetal chromosomal abnormalities through serological screening, the high risk of the fetal free DNA by non-invasive prenatal testing (NIPT), the abnormal results of the prenatal ultrasound examination and the history of adverse pregnancy and childbirth. The chromosome karyotype of the fetal cells in amniotic fluid and the prenatal diagnostic indications of the women were analyzed, then the pregnancy outcomes and the postnatal phenotype of the fetuses with SCA were followed up. Results: A total of 76 fetuses with SCA were found, with a detection rate of 0.7%. Among the SCA, 47, XXY accounted for 21.0%, 47, XXX accounted for 14.5%, 47, XYY accounted for 9.2%, 45, X accounted for 7.9%, 48, XXYY accounted for 1.3% and chimerism accounted for 46.0%. Among 76 women had the fetuses with SCA, 2 cases were lost to follow-up, and 17 (22.4%) cases continued to conceive. There were 57 (75.0%) women with the terminated pregnancy, including 16 cases with the fetal 47, XXY, 5 cases with the fetal 47, XXX, 5 cases with the fetal 47, XYY, 6 cases with the fetal 45, X, 1 case with the fetal 48, XXYY and 24 cases with the fetal chimerism, and the terminated pregnancy rates of which were 100%, 45.5%, 71.4%, 100%, 100%, and 68.6%, respectively. The most common indications of the prenatal diagnosis for the high-risk fetuses were the abnormal results of serological screening (31.6%) and NIPT of fetal free DNA (29.0%). The follow-up of 17 fetuses with SCA after birth were conducted. 1 infant with 47, XXX was followed up to 4 years and 4 months old and its delayed language and intellectual development accompanied by epileptic seizures was found. 1 infant with 47, XYY was followed up to 1 year and 2 months old and its concealed penis was found. The other 15 infants with SCA showed no the abnormalities in the physical development, the language development, the cognition, the physiological structure and the behavior during the follow up. Conclusion: The detection rate of SCA of the fetuses was 0.7%. The common prenatal diagnostic indications of the pregnant women with the fetal SCA are the high-risk results of the serological screening during mid pregnancy and NIPT. The combination of the serological screening and NIPT techniques combined with the amniotic fluid chromosome karyotype analysis can help to detect the fetuses with SCA. The women with the fetal 47, XXY and 45, X have the higher rate of termination pregnancy. For the fetuses with 47, XXX or SCA chimera, most of them have the normal postnatal phenotypes after birth.
2024 Vol. 32 (7): 1698- [Abstract]（
58
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
SUN Wei, WAN Li
To explore the effects of the one-to-one doula accompaniment during cesarean section for women on the maternal tension and pain and their neonatal status. Methods: 100 pregnant women who wanted the scheduled cesarean section in the hospital were selected and were divided into two groups (50 cases in each group) by the personal willingness of the women from June 2022 to December 2022. The women in the control group were given the usual care with a midwifery approach, and the women in the observation group were given the full course of one-to-one doula accompaniment care. The intraoperative sedatives used, the maternal bodily pain perception, the maternal tension, and the neonatal Apgar scores and body temperature of the women were compared between the two groups. Results: The number of the intraoperative drugs additional used (0.82±0.39 times) and the postpartum VAS score (4.90±1.15 points) of the women in the observation group were significantly less than those (1.06±times and 5.76±1.14 points) of the women in the control group. The rate of the decreased anxious degree (96.0%) of the women in the observation group was significantly higher than that (62.0%) of the women in the control group (all P<0.05). There were no significant differences in neonatal Apgar score (9.14±0.73 points vs. 8.96±0.86 points), the neonatal body temperature at 30 minutes after delivery (36.53±0.23℃ vs. 36.37±0.28℃) and the incidence of the neonatal hypothermia at 30 minutes after delivery (1 case in the observation group and 3 cases in the control group) between the two groups (P>0.05). Conclusion: The one-to-one doula accompanying the whole process for the women during cesarean section can promote their labor and postpartum recovery, can relieve the maternal pain and regulate the maternal tension, and which is benefit to reduce the incidence of the neonatal hypothermia.
2024 Vol. 32 (7): 1703- [Abstract]（
66
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
-
LU Jueyun，LANG Peng，LI Xin，LING Xiufeng
Assisted reproductive technology (ART) is currently the main method for treating the infertility patients, but its adverse effects on the development of the placenta of the patients with pregnancy after ART is worthy to attention and discussion. In recent years, more and more studies have shown that ART may have an impact on the epigenetic regulation of the placenta, and thus can lead to the adverse pregnancy outcomes. The environment of the in vivo and in vitro processes of ART differ from that of the natural pregnancy, which may lead to the placental epigenetic abnormalities, including the DNA hypomethylation, the abnormal histone modification, the expression dysregulation of the imprinted genes, the interference with chromatin remodeling process and the abnormal expression of non-coding RNA, and so on. This article reviews the influence of ART on the placental epigenetic regulation and development.
2024 Vol. 32 (7): 1707- [Abstract]（
39
）
HTML
(0 KB)
PDF
(0 KB)
(
7
)
-
WANG Qi, ZHANG Yanjun
Maternal and child health is not only related to the happiness of families, but also to the development of the country and the future of the nation. In recent years, with the proportion of the advanced pregnant and delivery women has increased gradually, and the incidence of the urgent and critical illnesses in pregnant and delivery women has also been increasing continuously. The urgent and critical illness of the pregnant and delivery women have the characteristics of rapid onset and rapid disease progression, if which have not been treated in a timely manner, it can seriously affect the pregnancy outcomes and can greatly damage the health of mothers and infants. The prehospital emergency is an important link in the treatment of the urgent and critical illness in the pregnant and delivery women. Building a comprehensive prehospital chain first aid process system can save the valuable treatment time of the urgent and critical illness in the pregnant and delivery women and can improve the maternal and infant outcomes. This article summarizes the pregnancy outcomes of the pregnant and delivery women with urgent and critical illness, the construction method of the prehospital chain first aid process, and the correlation between the pregnancy outcomes of the pregnant and delivery women with urgent and critical illness and their prehospital chain first aid process, aiming to provide the reference for reducing the impact of the urgent and critical illness on the maternal and infant health.
2024 Vol. 32 (7): 1712- [Abstract]（
66
）
HTML
(0 KB)
PDF
(0 KB)
(
8
)
