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Abstract To investigate the correlation between the semen quality of infertile men and their reproductive hormone and adipokines levels. Methods: 155 infertile men were selected in this study, including 53 cases with BMI<24 kg/m2 in group A, 53 cases with 24≤BMI<28 kg/m2 in group B and 49 cases with BMI≥28 kg/m2 in group C. CASA was used to measure the semen parameters of these infertile men. Chemiluminescent immunoassay was used to determine the serum reproductive hormones levels, and ELISA was used to measure the levels of the serum and plasma adipokine leptin (LEP), lipocalin (ADPN) and zinc α2 glycoproteins (ZAG) of the infertile men. The correlation between the semen parameters and the reproductive hormones levels of the infertile men and their serum and plasma LEP levels was analyzed. Results: The semen volume (t=-3.239, P=0.002), the sperm motility (t=-3.449, P=0.001), the serum testosterone level (t=-5.522, P<0.001) and the ZAG level (t=-3.354, P=0.001) of the infertile men in group B were significantly lower than those of the infertile men in group A. The seminal plasma ADPN level of the 155 infertile men was negative correlation with their BMI value (r=-0.160, P<0.05), but which was positively correlated with their semen volume, sperm concentration and total sperm count (r=0.250, r=0.250, r=0.368, P<0.05). The seminal plasma ZAG level of the infertile men was negatively correlated with their BMI value, sperm concentration and total sperm count (r=-0.254, r=-0.213, r=-0.178, P<0.05). There was no correlation between the seminal adipokines level of the infertile men and their blood adipokines level. Conclusion: Obesity can affect the serum testosterone level and semen quality of the infertile men. The seminal ADPN and ZAG levels of the infertile men are closely related to their semen quality.
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