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| Prevalence of the anxiety and depression of patients during the treatment of assisted reproductive technology: a meta-analysis |
| 1. School of Public Health, Lanzhou University, Lanzhou, Gansu Province, 730000；2. Gansu Provincial Maternity and Child Care Hospital, Lanzhou |
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Abstract To systematically evaluate the prevalence of the anxiety and depression of patients during the treatment of assisted reproductive technology. Methods: The databases, such as PubMed, Cochrane Library, EMBASE, Web of Science, CBM, CNKI and WanFang, from the inception dates to April 4, 2023 were searched by computer to collect the cross-sectional studies on the current status of the anxiety and depression of the patients during the treatment of assisted reproductive technology. Two researchers selected the literature, extracted the data and evaluated the risk of bias of the included studies independently. The meta-analysis was performed using Stata 15.1. Results: A total of 27 cross-sectional studies were included in for meta-analysis, with a total sample size of 9876 with anxiety and 13,207 patients with depressed. Meta analysis showed that the prevalence of the anxiety and the depression of the male patients were 13% and 28%, and the prevalence of the anxiety and the depression of the female patients were 32% and 36%. The subgroup analysis showed that the prevalence of the mild, moderate, and severe anxiety of the patients were 21.0%, 4.0%, and 0.6%, respectively, and the prevalence of the mild, moderate, severe and very severe depression of the patients were 28.0%, 11.0%, 1.0% and 0.3%, respectively. The prevalence of the anxiety of the patients with assisted reproductive technology in South China, Northwest China, Central China, Southwest China, North China and East China were 24%, 21%, 34%, 10%, 30% and 29%, respectively, and the prevalence of the depression of the patients with assisted reproductive technology in South China, Northwest China, Central China, Southwest China, North China and East China were 39%, 41%, 38%, 27%, 29% and 33%, respectively. Conclusion: The evidences available showed that the prevalence of anxiety and depression of the patients during the treatment of assisted reproductive technology is still at a high level, and which should be confirmed by more high-quality studies because of the limited of this meta-analysis by the quantity and the quality of the included studies.
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