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| Effect of nasal intermittent positive pressure ventilation combined with less invasive surfactant administration for treating premature infants with neonatal respiratory distress syndrome and its influence on the arterial blood gas and incidences of adverse events |
| 1.Maternal and Child Health Care Hospital, Guang'an, Sichuan Province, 638000；2. Guang'an Hospital of West China, Sichuan University, Guang'an |
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Abstract To explore the effect of nasal intermittent positive pressure ventilation (NIPPV) combined with less invasive surfactant administration (LISA) for treating premature infants with neonatal respiratory distress syndrome (NRDS), and to study its influence on the arterial blood gas and incidences of adverse events of the premature infants. Methods: From June 2020 to September 2023, 96 premature infants with NRDS were selected and were divided into observation group (48 cases) and control group (48 cases) according to the simple randomization grouping method. The infants in both groups were given non-invasive assisted ventilation in the neonatal intensive care unit. The infants in the control group received NCPAP treatment, while the infants in the observation group received NCPAP combined with LISA treatment. The clinical treatment status, the values of arterial blood gas indicators, such as arterial partial oxygen pressure (PaO2), arterial partial pressure of carbon dioxide (PaCO2), arterial oxygen saturation (SiO2) and PH, the values of pulmonary oxygenation indexes, such as arterial partial oxygen pressure/partial alveolar oxygen pressure (PaO2/PAO2) and oxygenation index (OI), and the incidence of adverse events of the infants were compared between the two groups. Results: After treatment, the non-invasive ventilation time (5.3±1.7d), the proportion of invasive ventilation (16.7%), the total oxygen therapy time (10.7±2.2d), and the duration of hospital stay (27.9±4.3d) of the infants in the observation group were significantly lower than those (6.6±2.0d, 35.4%, 12.4±2.5d and 31.6±5.1d) of the infants in the control group. The successful rate of stopping ventilation (87.5%) of the infants in the observation group was significantly higher than that (72.9%) of the infants in the control group. The values of PaO2, SiO2, PaO2/PAO2 and PH of the infants in the two groups after treatment had increased significantly, and the PaCO2 and OI values of the infants in the two groups after treatment had decreased significantly, and the improvement of which of the infants in the observation group were significantly greater than those of the infants in the control group. The total incidence of adverse events (8.3%) of the infants in the observation group was significantly lower than that (25.0%) of the infants in the control group (all P<0.05). Conclusion: NIPPV combined with LISA for treating the premature infants with NRDS can effectively improve their arterial blood gas, enhance their pulmonary ventilation, promote the improvement of their clinical symptoms and shorten their hospital stay.
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