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| Prediction of the coagulation parameters values combined with the elastography of pregnant women with gestational thrombocytopenia for their delivery outcomes |
| 1.Shandong Second Medical University, Weifang, Shandong Province, 261053; 2. Dezhou Hospital, Qilu Hospital of Shandong University, Dezhou, Shandong Province |
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Abstract To investigate the values changes of the coagulation parameters combined with the elastography (TEG) of pregnant women with gestational thrombocytopenia (GT), and to study their predictive value for the delivery outcomes of the women. Methods: The clinical data of 110 pregnant women who had delivered in the hospital from January 2020 to December 2023 were collected in this study. The occurrence of the GT of the women was determined according to their platelet count (PLT), and these were women divided into group A (58 women with GT and the PLT value <100×109/L) and group B (52 women without GT and the PLT value ≥100×109/L). The values of the coagulation indexes and TEG parameters of the women were compared between the two groups. Spearman correlation coefficient was used to analyze the correlation between the levels of the prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and the TEG parameters of the women and the incidence of their GT. The women in group A were divided into group A1 (women with the normal delivery outcomes) and group A2 (women with the poor delivery outcomes), and the values of the coagulation indexes and TEG parameters of the women were compared between the two groups. ROC curve was drawn to analyze the clinical values of the coagulation indexes and TEG parameters values of the women with GT in group A for diagnosing their delivery outcomes. Results: There were no significantly differences in the PT, APTT, TT and FIB levels of the women were compared between the group A and group B (P>0.05). The blood clot formation rate (Angle), the maximum amplitude of blood clots (MA) and the coagulation index (CI) value of the women in group A were all significantly lower than those of the women in group B. The incidence of GT of the women was no correlated with their PT, APTT, TT and FIB levels, while which was negatively correlated with their Angle, MA and CI value (all P<0.05). There were no significant differences in the PT, APTT, TT and FIB levels of the women between group A2 and group A1 (P>0.05). The Angle, MA and CI value of the women in group A2 were significantly lower than those of the women in group A1 (P<0.05). The area under the curve, the sensitivity and the specificity of the blood coagulation indexes levels combined with the TEG parameters values of the women with GT for diagnosing their delivery outcomes were 0.916, 92.3% and 93.8%, respectively, and which were significantly higher than those of the blood coagulation indexes values or the TEG parameters values (all P<0.05). Conclusion: There are no significant changes in the routine coagulation indexes of the pregnant women with GT, indicating that GT have no obvious impact on their coagulation function index. While, the values of TEG parameters of the pregnant women with GT are decreased abnormally. The blood coagulation indexes levels combined with the TEG parameters values of the women with GT for predicting their delivery outcomes can increase the predictive efficacy.
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