To investigate the depression current situation of pregnant women with scarred uterus (SU) during the third trimester of pregnancy, and to analyze the influencing factors of the depression. Methods: From January 2021 to December 2023, 278 pregnant women with SU who underwent prenatal examinations in hospital were selected in this study. These women were all evaluated by the patient health questionnaire (PHQ-9) during the third trimester of pregnancy, and based on the evaluation results, these women were divided into group A (women with depression) and group B (women without depression). The 17 items of the data in PHQ-9 of the women were collected and were compared between the two groups. Multivariate analysis was applied to screen the influencing factors of the depression occurrence of the pregnant women with SU during the third trimester of pregnancy. Results: 22.3% (62/278) women with SU had depression during the third trimester of pregnancy. There were significant differences in the educational background, the adverse pregnancy experience, the sleep status, the pregnancy complications rate, the introverted personality rate, the family care situation, and the recent negative life events of the women between group A and group B (P<0.05). The influencing factors of the depression occurrence of the pregnant women with SU during the third trimester of pregnancy mainly included the adverse pregnancy experience (OR=2.816, 95%CI 1.570-5.050), the poor sleep status (OR=2.514, 95%CI  1.377-4.589), and the introverted personality rate (OR=2.408, 95%CI 1.289-4.500), the poor family care (OR=3.022, 95%CI 1.708-5.316) and the recent negative life events (OR=2.862, 95%CI 1.577-5.193). Conclusion: The adverse pregnancy experiences, the poor sleep status, the introverted personality, the poor family care and the recent negative life events of the pregnant women with SU are related to their depression during the third trimester of pregnancy. Therefore, the targeted education, the psychological support and the health behavior interventions for these women based on these influence factors should be provided to prevent the occurrence of their depression.