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| Effects of laparoscopic lesion resection combined with uterine artery occlusion for treating patients with adenomyosis on their neutrophil-lymphocyte ratio and their levels carbohydrate antigen 125 and transforming growth factor β1 |
| First Medical Center, General Hospital of PLA, Beijing, 100039 |
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Abstract To investigate the effects of laparoscopic lesion resection combined with uterine artery occlusion for treating patients with adenomyosis on their neutrophillymphocyte ratio (NLR), and their levels of carbohydrate antigen 125 (CA125) and transforming growth factor β1 (TGF-β1). Methods: 210 patients with adenomyosis were collected and were randomly divided into control group (105 cases with laparoscopic lesion resection) and observation group (105 cases with laparoscopic lesion resection combined with uterine artery occlusion) from September 2020 to August 2023. The surgical time, the intraoperative blood loss, the menstrual volume before surgery and in 6 months after surgery, the pain status, the uterine volume, the ovarian function, the NLR, and the levels of CA125 and TGF-β1 of the patients were compared between the two groups. Results: The intraoperative blood loss (276±35ml) and the operation time (87±25min) of the patients in the observation group were significantly lower than those (357±26ml and 115±36 min) of the patients in the control group. The menstrual volume in 6 months after surgery (12.44±2.14 pads/month), the VAS score (2.06±0.62 points), the uterine volume (89.47±14.25 cm3), the NLR (2.06±0.86), and the levels of CA125 (20.35±2.71 KU/L) and TGF-β1 (35.98±8.12 mg/L) of the patients in the observation group were significantly lower than those (15.63±1.56 pads/month, 2.45±0.78 points, 95.36±12.36 cm3, 2.45±0.95, 24.53±2.48 KU/L and 42.63±8.56 mg/L) of the patients in the control group. In 1 week after surgery, the level of estradiol (159.36±24.71 pg/ml) of the patients in the observation group was significantly lower than that (168.47±27.06 pg/ml) of the patients in the control group. The levels of luteinizing hormone (11.59±3.18 U/L) and follicle stimulating hormone (27.56±3.84 U/L) of the patients in the observation group were significantly higher than those (10.57±2.87 U/L and 26.51±3.49 U/L) of the patients in the control group (all P<0.05). In 6 months after surgery, there were no significant differences in the sex hormones levels of the patients between the two groups, and there was no any patient with the adenomyosis recurrence. Conclusion: Both laparoscopic lesion resection and laparoscopic lesion resection combined with uterine artery occlusion can be used to treating adenomyosis of the patients. Laparoscopic lesion resection combined with uterine artery occlusion for treating the patients with adenomyosis has more advantages in the surgical efficiency, the improvement of dysmenorrhea symptoms and reduction of the levels of NLR, CA125 and TGF-β1of the patients, and which has less impact on the ovarian function of the patients.
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