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| Predictive factors and the preventive measures of neonates with hypoglycemia delivered by the pregnant women with gestational diabetes mellitus |
| Wuhu Hospital Affiliated to East China Normal University, Wuhu, Anhui Province, 241000 |
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Abstract To explore the predictive factors of neonates with hypoglycemia delivered by the pregnant women with gestational diabetes mellitus (GDM), and to put forward the preventive measures accordingly. Methods: The clinical data of 122 pregnant women with GDM and their neonates admitted to the hospital from January 2020 to January 2023 were analyzed retrospectively. According to whether the neonates had hypoglycemia, there were 26 women with neonatal hypoglycemia and 96 women without neonatal hypoglycemia. Univariate analysis and logistic multivariate regression model were used to explore the influencing factors of the neonatal hypoglycemia of the pregnant women with GDM. The regression prediction model was established, and its predictive power was evaluated. Results: In 122 pregnant women with GDM, there were 26 women with neonatal hypoglycemia within 48 h after birth, with the incidence of 21.3%. Multivariate analysis showed that poor blood glucose control of the women during pregnancy, the neonatal premature delivery and low birth weight, the time ≥30 minutes from the neonatal birth to the first feeding and the neonatal hyperbilirubinemia were the independent risk factors of the hypoglycemia occurrence of the neonates delivered by the women with GDM, and the regular prenatal care during pregnancy of the women with GDM was an independent protective factor for their neonatal hypoglycemia occurrence (all P<0.05). The regression prediction model established based on the above factors had a high goodness of fit. Receiver operating characteristic (ROC) curve analysis showed that the area under the curve, the sensitivity, the specificity and the accuracy of this model for predicting the hypoglycemia occurrence of the neonates delivered by pregnant women with GDM were 0.866, 61.5%, 94.8% and 87.7%, respectively. Conclusion: The poor blood glucose control during pregnancy, the neonatal premature birth and low birth weight, the time ≥30 minutes from the neonatal birth to the first feeding, the neonatal hyperbilirubinemia and the nonregular prenatal examination during pregnancy of the pregnant women with GDM are all the influencing factors of their neonatal hypoglycemia occurrence, and the prediction model constructed based on these influencing factors has the good predictive efficacy.
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