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| Predictive value of the combined detections of prenatal serum brain natriuretic peptide, cardiac troponin I and D-dimer of pregnant women for their pulmonary embolism occurrence#br# |
| 1. Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning Province, 111004; 2. General technology Baoshi Flower Medical Jilin City Chemical Hospital, Jilin City |
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Abstract To explore the predictive value of the combined detections of prenatal serum brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and D-dimer of pregnant women for their pulmonary embolism occurrence. Methods: The clinical data of 35 pregnant women with pulmonary embolism (in study group) and 50 pregnant women without pulmonary embolism (in control group) who underwent prenatal examinations in the hospital from September 2018 to September 2023 were collected. Multivariate logistic regression was used to analyze the influencing factors of the pulmonary embolism occurrence of the pregnant women. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the prenatal serum BNP, cTnI and D-dimer levels of the women for their pulmonary embolism occurrence. Results: The levels of serum BNP (110.36±14.52 pg/ml), cTnI (0.73±0.29 ng/ml) and D-dimer (2.81±0.29μg/ml) of the women in the study group were significantly higher than those (89.72±11.87 pg/ml, 0.44±0.07 ng/ml and 2.46±0.25μg/ml) of the women in the control group. The abnormal increase serum BNP, cTnI and D-dimer levels of the women were all the independent risk factors of their pulmonary embolism occurrence. The areas under the curve of the prenatal serum BNP level, the cTnI level, the D-dimer level and the combined prenatal serum BNP, cTnI, D-dimer levels of the women for predicting their pulmonary embolism occurrence were 0.857, 0.851, 0.858, 0.921, respectively, and the combined prenatal serum BNP, cTnI, D-dimer levels of the women had the highest prediction efficiency (all P<0.05). Conclusion: The levels of prenatal serum BNP, cTnI, and D-dimer of the pregnant
women with pulmonary embolism are up-regulation, and all of which are the independent risk factors of their pulmonary embolism occurrence. The combined prenatal serum BNP, cTnI, D-dimer levels of the women has higher prediction value for the pulmonary embolism occurrence of the women.
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