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| Effect of lactobacillus vaginal capsule combined with metronidazole vaginal administration for treating patients with atrophic vaginitis and its influence on the vaginal microecology |
| The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, Sichuan Province, 610057 |
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Abstract To explore the effect of lactobacillus vaginal capsule combined with metronidazole vaginal administration for treating patients with atrophic vaginitis. Methods: The clinical data of the patients with atrophic vaginitis admitted to outpatient department for treatment from January 2021 to August 2023 were analyzed retrospectively. 73 patients were randomly selected from the patients who had accepted treatment of metronidazole vaginal administration in control group, and 73 patients were randomly selected from the patients who had accepted treatment of metronidazole combined with lactobacillus vaginal capsule in observation group. The clinical efficacy and the positive rate of lactobacillus after 14 days of treatment of the patients were compared between the two groups. The distribution status of the vaginal flora (lactobacillu, enterobacter and candida albicans), the vaginal microecology, the vaginal microcirculation (erythrocyte aggregation rate) and the vaginal inflammatory factors levels of the patients in the two groups before and after treatment were recorded. Results: After 14 days of treatment, the total effective rate (90.4%) and the positive rate of lactobacillus (83.6%) of the patients in the observation group were significantly higher than those (74.0% and 68.5%) of the patients in the control group. The lactic acid bacteria content of the patients in the two groups after treatment had increased significantly, and which (8.94±1.48 cfu/ml) of the patients in the observation group was significantly higher than that (7.35±1.26 cfu/ml) of the patients in the control group. The aggregation rates of Enterobacter, Candida albicans and erythrocyte, and the inflammatory factors levels of the patients in the two groups after treatment had increased significantly, and which of the patients in the observation group were significantly lower than those of the patients in the control group. The proportions of the secretion pH≤4.5 (91.8%), the flora density of grade II-III (87.7%) and the dominant bacteria of lactic acid bacteria (89.0%) of the patients in the observation group were significantly higher than those (67.1%, 71.2% and 69.9%) of the patients in the control group (all P<0.05). Conclusion: Metronidazole combined with lactobacillus vaginal capsule for treating the patients with atrophic vaginitis can help improve their vaginal microecology and microcirculation.
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