To understand the anxiety of unmarried women before induced abortion, to explore the influencing factors and its predictive value of the women, and to provide reference for the effective psychological intervention. Methods: A total of 148 unmarried women who planned to undergo induced abortion in the hospital from May 2020 to May 2022 were selected in this study. The self-made general information questionnaire, the self-rating anxiety scale (SAS) and the pain disclosure index scale (DDI) were used for the anonymous investigation. Univariate analysis and multivariate logistic regression analysis were used to explore the influencing factors of the anxiety of the unmarried women before induced abortion. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of the related influencing factors of the unmarried women for their anxiety before induced abortion. Results: A total of 142 unmarried women who planned to undergo induced abortion were included in this study, and with the SAS score of 52.97±4.03 points. And among them, there were 102(71.8%) cases with anxiety, and the SAS score of the 102 women was 57.82±3.26 points. There were 40(28.2%) cases without anxiety, and the SAS score of these 40 women was 40.61±4.59 points. Univariate analysis showed that the age, the occupation, the history of induced abortion, the understanding of reproductive health knowledge, the abortion method, the contraceptive attitude of the sexual partners and the self-disclosure of the unmarried women were significantly related to their anxiety before induced abortion (P<0.05). Multi-factor analysis showed that the proposed medical abortion, the young women, the poor reproductive health knowledge level and the low level of self-disclosure of the unmarried women had significantly greater risk of their anxiety before induced abortion (P<0.05). ROC curve analysis showed that the each influencing factor of the unmarried women all had the good predictive value for their anxiety occurrence before abortion, and with the area under the curve of 0.622-0.655. Conclusion: The medical abortion, the young women, the poor reproductive health knowledge level and the low level of self-disclosure of the unmarried women are significantly related to their anxiety before induced abortion, and all of which has certain predictive efficacy for their anxiety before induced abortion, and so the clinical countermeasures should be taken accordingly.

2024 Vol. 32　(10):　2220- [Abstract]（ 72 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

To explore the influencing factors of the maternal-infant relationship of women with premature delivery in their early postpartum period, and to put forward the countermeasures. Methods: A total of 170 women with premature delivery from August 2022 to July 2023 were selected as the research objects. These women were investigated by general data questionnaire when they came to the hospital for reexamination in the 42th day after delivery. Chinese version of maternalinfant attachment scale (CMAI), Chinese version of postpartum fatigue scale (PFS), Chinese version of parenting confidence scale (KPCS) and infant temperament questionnaire (EITQ) were used for investigation. Multivariate linear regression model was used to analyze the influencing factors of the maternal-infant relationship of the premature women with premature delivery in early postpartum period. Results: A total of 170 questionnaires were distributed, and 158 valid questionnaires were effectively recovered, with an effective recovery rate of 92.9 %. The scores of CMAI, PFS and KPCS of the women were 73.48±10.62 points, 22.56±3.28 points and 35.61±4.12 points, respectively. Pearson correlation analysis showed that the PFS score of the women was negatively correlated with their CMAI score, and the KPCS score of the women was positively correlated with CMAI score (all P<0.001). Univariate analysis showed that there was significant difference in the CMAI score in the early postpartum period among the women with different ages, among the women with different family monthly income, among the women with different delivery mode, among the women with different parity, among the women with different temperament type of premature infants, among the women with different feeding mode, and between the women with and without maternal-infant separation during hospitalization. Multivariate analysis showed that the age <35 years old, the parity, the maternal-infant separation during hospitalization, the temperament type of the premature infants, the artificial feeding mode, the high degree of the postpartum fatigue and the low parenting confidence of the women with premature delivery were the independent influencing factors of their maternal-infant relationship in early postpartum period (all P<0.05). Conclusion: This survey has showed that the maternal-infant attachment of the women with premature delivery in their early postpartum period is at the medium level. The intervention should be conducted aimed at the correlated factors, so as to establish and maintain the good maternal-infant relationship.

2024 Vol. 32　(10):　2231- [Abstract]（ 66 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

To study the current status of the discharge preparedness of primiparas, and to analyze its influencing factors. Methods: From January 2022 to November 2022, the convenient sampling was used to select 200 primiparas who had delivered in the hospital as the study subjects. The general information of the primiparas were collected. The readiness for the hospital discharge, the perceived social support, the guiding quality of discharge and the family care indexes of the primiparas were evaluated. The influencing factors of the discharge preparedness of the primiparas were analyzed. Results: The score of the discharge preparedness of the primiparas was 110.17±23.55 points (the total score of 180 points). There was significant difference in the discharge preparedness score among the primiparas with the different self-rated confidence in nursing newborns, among the primiparas with the different premature delivery, among the primiparas with the different the puerperium nursing model, among the primiparas with the different maternal and infant status at discharge and among the primiparas with the different pregnancy complications (all P<0.05). The discharge preparedness of the primiparas was positively correlated with their perceived social support, discharge guidance quality and family care indexes (all P<0.05). Multiple linear regression analysis showed that the maternal and infant separation, the pregnancy complications, the low perceived social support, the low quality of discharge guidance and the low family care indexes of the primiparas at discharge were the factors affecting their discharge preparedness (all P<0.05). Conclusion: The discharge preparedness of the primiparas in this survey is relatively low totally. The health care providers should focus on the primiparas about their maternal and infant separation, and discharge guidance. The diverse support system should be provided to these primiparas, so as to enhance their discharge preparedness.

2024 Vol. 32　(10):　2242- [Abstract]（ 45 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

To understand the current situation of the labor analgesia willingness of advanced primiparas, and to analyze the influencing factors of the labor analgesia willingness of the advanced primiparas. Methods: From February 2022 to September 2023, 532 advanced primiparas who underwent prenatal examinations atHaian People's Hospital were selected as survey subjects by convenience sampling method. The labor analgesia willingness of these primiparas was evaluated and the influencing factors of the labor analgesia willingness of these primiparas were analyzed. Results: Among all these respondents, 201 (37.8%) advanced primiparas had the willingness to choose labor analgesia. Multivariate analysis showed that the bachelor degree or above (OR=2.765, 95%CI 1.1816.473), the medical education background (OR=2.045, 95%CI 1.305-3.203), the spouse support (OR=3.021, 95%CI 1.329-6.868), the fear of pain (OR=1.813, 95%CI 1.305-3.203) and the acquired knowledge of labor analgesia (OR=2.867, 95%CI 1.043-7.882) of the respondents were more willing to choose the labor analgesia. Conclusion: The professionals in the medical institutions should strengthen the health education health education related to the labor analgesia for the pregnant women, and should actively promote the popularity rate of the labor analgesia in the pregnant women.

2024 Vol. 32　(10):　2255- [Abstract]（ 44 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

To compare the effect of the dizosin and remimazolam combined with propofol for the painless abortion of women, and to study their influence on the serum central nervous system specific protein (S100β) and interleukin-6 levels (IL-6) of the women. Methods: 90 women who wanted painless abortion voluntarily were selected as the study subjects and were randomly divided into two groups by random number table from June 2021 to December 2023. The women in group A were given remimazolam combined with propofol for the painless abortion, and the women in group B were given dizosin combined with propofol for the painless abortion. The anesthesia effects and the changes of the serum S100β and IL-6 levels of the women were compared between the two groups. Results: The analgesic effect of the women in group B was significantly better than that of the women in group A. The intraoperative blood oxygen saturation (98.25±3.13) %, the heart rate (77.71±7.98 times/min), the respiratory rate (17.26±1.76 times/min) and the mean arterial pressure (79.66±3.82 mmHg) of the women in group B were significantly higher than those (95.51%±3.10%, 70.46±7.12 times/min, 15.13±1.53 times/min and 76.37±3.89 mmHg) of the women in group A. The NRS score of the postoperative pain (2.05±0.54 points) of the women in group B was significantly lower than that (3.10±0.62 points) of the women in group A. The dosage of propofol (112.16±13.34 mg) of the women in group B was significantly less than that (181.95±20.12 mg) of the women in group A. The levels of the serum S100β (1.07±0.34 mu g/ml) and IL-6 (22.94±6.49) of the women in 24h after abortion of the women in group B were significantly lower than those (1.52±0.47μg/ml and 32.62±8.02 ng/L) of the women in group A. The incidence of adverse reactions (4.4%) of the women in group B was significantly lower than that (17.8%) of the women in group A (all P<0.05). Conclusion: Compared with those of remimazolam combined with propofol for the painless abortion of the women, the dizosin combined with propofol for the painless abortion of the women has the better anesthesia effect, which can not only alleviate the surgical pain of the women, but also can decrease the probability of their adverse reactions and alleviate their cognitive impairment.

2024 Vol. 32　(10):　2266- [Abstract]（ 44 ） HTML (0 KB)  PDF  (0 KB)  ( 12 )

To compare the effects of the different concentrations of ropivacaine used in the combined spinal epidural anesthesia during cesarean section of women with gestational iabetes mellitus (GDM) on their microcirculation and oxidative stress response. Methods: 150 pregnant women with GDM who wanted cesarean section were randomly divided into three groups (50 cases in each group) from January 2022 to December 2023. The women in group A, group B and group C during the combined spinal epidural anesthesia for their cesarean section were given ropivacaine concentrations of 0.25%, 0.375%, and 0.5%, respectively. And the anesthesia effect of the women was compared among the three groups. Results: The onset time of the sensory block or the motor block of the women in group B and in group C were significantly shorter than those of the women in group A. At 10min after anesthesia and at the time of the fetal delivery, the mean arterial pressure values of the women in group B and in group C were significantly lower than those of the women in group A. The heart rate values of the women in group B and in group C were significantly higher than those of the women in group A. The VAS scores of the women in group B or in group C at 1, 2, 12 and 24h after operation were significantly lower than those of the women in group A. The length and the width of the loop of the women in group B and in group C in postoperative 24 hours were significantly higher than those of the women in group A. The malondialdehyde of the women in group A, in group B and in group C in postoperative 24 hours had decreased gradually, but the superoxide dismutase level had increased gradually. The incidence of the adverse reactions (4.0% vs. 14.0% vs. 26.0%) of the women had significant difference among the three groups, and which of the women in group C was the highest (P<0.05). Conclusion: The effect of the different concentrations of ropivacaine used in the combined spinal epidural anesthesia during cesarean section of women with GDM is different.  0.375% ropivacaine used in the combined spinal epidural anesthesia can meet the anesthesia needs and has acceptable safety, that making it worth applying.

2024 Vol. 32　(10):　2277- [Abstract]（ 52 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

2024 Vol. 32　(10):　2288- [Abstract]（ 48 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

2024 Vol. 32　(10):　2298- [Abstract]（ 51 ） HTML (0 KB)  PDF  (0 KB)  ( 10 )

To analyze the effects of the insulin pump and basal insulin therapy at meal for pregnant women with gestational diabetes mellitus (GDM) on their neonatal prognosis. Methods: 147 pregnant women with GDM who were diagnosed and treated in the hospital were selected from May 2020 to December 2022, including 72 women who were treated with individualized insulin pump in group A and 75 patients who were treated with individualized basal insulin therapy at meal in group B. The gestational weeks at delivery, the proportions of the blood glucose reaching target during pregnancy after treatment and the requiring cesarean section of the women were compared between the two groups. The first minute Apgar score and the rates of the perinatal adverse complications, such as premature infants, macrosomia, fetal acute distress and neonatal hypoglycemiam, of the neonates were compared between the two groups. The obese situation of the infants at 3 and 12 months after born were followed and were compared between the two groups. Results: There were no significant diffrences in the gestational weeks at delivery, the proportions of the normal blood glucose level after treatment during pregnancy and the cesarean section needed, and the neonatal 1 min Apgar score of the women between the two groups (P>0.05). The incidence of the neonatal adverse perinatal complications (2.8%) of the women in group A was significantly lower than that (12.0%) of the women in group B. The incidence of the infant obesity (4.2%) in group A was significantly lower than that in group B (14.7%) in the 12th month after birth (all P<0.05). Conclusion: The insulin pump therapy for the pregnant women with GDM has the same effectiveness as the basal insulin therapy at meal in controlling their blood glucose level during pregnancy, and which is superior to the basal insulin therapy at meal in the reducing neonatal adverse perinatal complications and the infant obesity in the 12th month after birth.

2024 Vol. 32　(10):　2308- [Abstract]（ 41 ） HTML (0 KB)  PDF  (0 KB)  ( 7 )

To investigate the effects of En Caul cesarean section for women with preterm labor on their perinatal blood loss and neonatal outcomes. Methods: 80 women with preterm labor who wanted cesarean section were selected and were randomly divided into two groups (40 case in each group) from January 2020 to January 2023. The women in the observation group were given En Caul cesarean section and the women in the control group were given traditional cesarean section. The perinatal blood loss, the operation-related indexes, and neonatal outcomes of the women in the two groups were recorded. Results: The perinatal blood loss (500.24±90.77 ml) of the women in the observation group was significantly less than that (590.30±105.19 ml) of the women in the control group. The Apgar scores of the newborns in the observation group at 1min (8.42±0.95 points) and at 5min (9.64±0.22 points) after birth were significantly higher than those (7.75±1.10 points and 9.40±0.31 points) of the newborns in the control group. The levels of the neonatal blood lactic acid (1.71±0.20 mmol/L) and the creatine kinase (246.90±49.77 U/dl) of umbilical cord blood, and the creatine kinase isoenzyme (72.09±12.68 U/dl) in the observation group were significantly lower than those (1.89±0.44 mmol/L, 305.464±80.54 U/dl and 89.67±20.54 U/dl) in the control group. The incidences of the neonatal respiratory distress syndrome (0) and the neonatal asphyxia (2.5%) in the observation group were significantly lower than those (15.0% and 20.0%) in the control group (all P<0.05). Conclusion: En Caul cesarean section for treating the women with preterm labor can reduce their perinatal blood loss, reduce their neonatal complications incidence in the near term, improve their neonatal Apgar score, and have a positive impact on their neonatal outcomes.

2024 Vol. 32　(10):　2317- [Abstract]（ 33 ） HTML (0 KB)  PDF  (0 KB)  ( 10 )

2024 Vol. 32　(10):　2326- [Abstract]（ 46 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

To explore the influence of the group midwifery service model based on the maternal needs for primiparas on their role transition and lactation effect after delivery. Methods: The primiparas who were registered in the hospital and had regular antenatal examination from January 2023 to December 2023 were selected as the research subjects. According to the implementation time of the group midwifery service model based on the maternal needs in the hospital, 67 primiparas who admitted to hospital from January 2023 to June 2023 were included in control group and were given routine nursing, and another 67 primiparas who admitted to hospital between July 2023 and December 2023 were included in observation group and were given the group midwifery service model based on the maternal needs combined with the routine nursing. The role transition adaptability evaluated by the maternal role adaptation questionnaire, the parenting competence evaluated by Chinese version of parenting sense of competence scale (C-PSOC), the breastfeeding success rate evaluated by the exclusive breastfeeding, mixed feeding and artificial feeding situations, the breastfeeding indicators, such as the lactation onset time, the lactation volume at 24 hours after delivery and the lactation stimulation rate, and the postpartum depression evaluated by Edinburgh postnatal depression scale (EPDS) of the primiparas were compared between the two groups. Results: The score of the mother role adaptation of the primiparas in the observation group after postpartum 30d was significantly higher than that of the primiparas in the control group. The scores of C-PSOC parenting self-efficacy (41.28±2.36 points) and the satisfaction (46.74±3.08 points), the breast feeding rate (91.0%) and the breastfeeding index value of the primiparas in the observation group after postpartum 30d were significantly higher than those (37.92±2.18 points, 44.13±2.84 points and 77.6%) of the primiparas in the control group. The EPDS scores of the primiparas in the observation group in the postpartum 3rd d (7.58±1.21 points), in the postpartum 8th week (7.58±1.21 points) and in the postpartum 24th week group (7.27±1.06 points) were significantly lower than those (8.76±1.28 points, 8.14±1.23 points and 8.09±1.19 points) of the primiparas in the control group (P<0.05). Conclusion: The group midwifery service model based on the maternal needs for the primiparas can promote their smoothly role transition, enhance their parenting competence and breastfeeding success rate, improve their breastfeeding indicators and reduce their postpartum depression.

2024 Vol. 32　(10):　2336- [Abstract]（ 38 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

2024 Vol. 32　(10):　2345- [Abstract]（ 36 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

To investigate the influencing factors of the pelvic floor dysfunction (PFD) occurrence of patients after total laparoscopic hysterectomy. Methods: The clinical data of 71 patients with the complete data of the follow-up who had been total laparoscopic hysterectomy caused by benign uterine lesions from January 2022 to January 2023 were selected in this study retrospectively. The occurrence of PFD was statistically analyzed according to the reexamination results of the patients in 3 months after surgery. The influencing factors of PFD occurrence of the patients after total laparoscopic hysterectomy were analyzed by logistic regression analysis. Results: In 71 patients with PFD occurrence after total laparoscopic hysterectomy, there were 9 cases with pelvic organ prolapses, 5 cases with urinary incontinence and 4 cases with sexual dysfunction, with a total incidence of 25.4%. The proportions of the age >45 years old, the parity >2 times of the patients without regular pelvic floor muscle function exercise of the patients were significantly higher than those of the patients with normal pelvic floor function (P<0.05). The age >45 years old (OR=1.709, 95%CI: 1.062-2.752), the parity >2 times (OR=1.539, 95%CI: 1.048-2.260), no regular pelvic floor muscle function exercise (OR=1.471, 95%CI: 1.188-1.821) of the patients were the independent influencing factors of their PFD occurrence after total laparoscopic hysterectomy (all P<0.05). Conclusion: The incidence of PFD of the patients after total laparoscopic hysterectomy is relatively high, which is influenced by the age, the party time and the postoperative pelvic floor muscle functional exercise of the patients. The postoperative pelvic floor function exercise guidance and the health education of the patients should be actively carried out in clinic to improve their understanding and compliance of the pelvic floor muscle function exercise.

2024 Vol. 32　(10):　2353- [Abstract]（ 52 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

To explore the changes of the serum interleukin-16 (IL-16), interleukin-10 (IL-10) and procalcitonin (PCT) of neonates with pneumonia, and to study the diagnostic values of the IL-16, IL-10 and PCT levels of the neonates for differential the disease severity of their pneumonia. Methods: The clinical data of 92 neonates with pneumonia admitted to hospital from February 2021 to June 2023 were collected retrospectively and these neonates were included in observation group. 90 healthy neonates born during the same period were included in control group. The serum levels of IL-16, IL-10 and PCT of the neonates were compared between the two groups. Receiver operating characteristic (ROC) curve was used to analyze the values of serum IL-16, IL-10 and PCT levels of the neonates for diagnosing their pneumonia. According to the severity of the neonatal pneumonia in the observation group, the neonates were divided into group A (61 neonates without severe pneumonia) and group B (31 neonates with severe pneumonia). The serum levels of IL-16, IL-10 and PCT of the neonates were compared between group A and group B. ROC curve was used to analyze the values of serum IL-16, IL-10 and PCT levels of the neonates for diagnosing their severity of pneumonia. Results: The serum levels of IL-16 (336.82±100.51 ng/L), IL-10 (12.74±3.71 ng/L) and PCT (6.34±2.18μg/L) of the neonates in the observation group were significantly higher than those (123.65±29.74 ng/L, 8.94±1.87 ng/L and 3.51±1.33μg/L) of the neonates in the control group. ROC curve analysis showed that the area under the curve (AUC) of the serum IL-16 level, the IL-10 level and the PCT level of the neonates for diagnosing their pneumonia were 0.984, 0.815 and 0.873, respectively (all P<0.05). The serum levels of IL-16, IL-10 and PCT of the neonates in group A were significantly higher than those of the neonates in group B. ROC curve analysis showed that the AUC of serum IL-16, IL-10 and PCT of the neonates for diagnosing their severity of pneumonia were 0.964, 0.757 and 0.866, respectively (all P<0.05). Conclusion: The serum levels of IL-16, IL-10 and PCT of the neonates can effectively diagnose their pneumonia, and which have certain application value in evaluating the severity of the neonatal pneumonia.

2024 Vol. 32　(10):　2363- [Abstract]（ 45 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

To correlation between the levels of the preoperative serum CXC-class chemokine ligand 12 (CXCL12) and CXC-class chemokine receptor 4 (CXCR4) of patients with endometrial polyps and their intrauterine adhesions after the endometrial polypectomy. Methods: The clinical data of 86 patients who had undergone hysteroscopic cold knife resection of endometrial polyps from January 2021 to January 2023 were selected in this study. These patients were divided into group A (33 cases with intrauterine adhesion) and group B (53 cases without intrauterine adhesion) according to the results of the follow-up in the postoperative 1 year. The serum CXCL12 and CXCR4 levels of the patients in the two groups were detected within 24h after admission. Receiver operating characteristic (ROC) curve was used to evaluate the value of the serum CXCL12 and CXCR4 levels of the patients for their intrauterine adhesion after polypectomy. Binary logistic stepwise regression was used to analyze the related factors of the postoperative adhesion of the patients. Results: The operation time, the gravidity, the history of cesarean section, the history of curettage, the proportion of intrauterine device used, the history of pelvic inflammatory disease, the proportion of endometrial hyperplasia and the polyp diameter of the patients in group A were significantly higher than those of the patients in group B (P<0.05). The levels of preoperative serum CXCL12 (11.47±2.84pg/L) and CXCR4 (50.61±10.02pg/L) of the patients in group A were significantly higher than those (5.66±1.24pg/L and 23.26±5.69pg/L) of the patients in group B (all P<0.05). ROC curve analysis showed that the area under the curve of the preoperative serum CXCL12 level, the CXCR4 level and the combination of the CXCL12 and CXCR4 levels of the patients with endometrial polyps for evaluating the occurrence of their intrauterine adhesion after the polyp’s resection were 0.854, 0.866 and 0.925, respectively. Binary logistic stepwise regression analysis showed that the multiple pregnancies, the history of curettage, the pelvic inflammatory disease and the increased serum CXCL12 and CXCR4 levels of the patients were the risk factors of their intrauterine adhesion after the resection of endometrial polyps (all P<0.05). Conclusion: The serum CXCL12 and CXCR4 levels of the patients with endometrial polyps before endometrial polyp resection increase, which can be the risk factors of the postoperative intrauterine adhesions. The combination of the serum CXCL12 and CXCR4 levels of the patients has better diagnostic efficacy for the occurrence of their intrauterine adhesions after the resection of the endometrial polyp.

2024 Vol. 32　(10):　2372- [Abstract]（ 45 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

2024 Vol. 32　(10):　2382- [Abstract]（ 40 ） HTML (0 KB)  PDF  (0 KB)  ( 10 )

To explore the value of the ultrasound monitoring combined with the levels of blood urea nitrogen (BUN) and uric acid (UA) of pregnant women with preeclampsia (PE) complicated with fetal growth restriction (FGR) for predicting their adverse pregnancy outcomes. Methods: 106 pregnant women with PE from January 2020 to May 2023 were collected retrospectively, including 106 women complicated with FGR in observation group and 106 women without FGR in control group. The levels of BUN and UA, the values of peak systole velocity (PSV), peak diastolic velocity (EDV) and average maximum blood flow velocity (Vmax) of the venous catheter of the women were compared between the two groups. The adverse outcomes of the newborns and the pregnant women in the two groups were counted. Results: The levels of BUN (5.03±1.22mmol/L) and UA (435.54±52.13mmol/L) of the women in the observation group were significantly higher than those (4.01±1.30 mmol/L and 391.60±60.88 mmol/L) of the women in the control group. The values of PSV (0.85±0.12cm/s), EDV (0.78±0.11cm/s) and Vmax (0.81±0.13cm/s) of the women in the observation group were significantly lower than those (0.89±0.11 cm/s, 0.96±0.14 cm/s and 0.98±0.12 cm/s) of the women in the control group. The total incidence of the neonatal adverse outcomes (67.9%) in the observation group was significantly higher than that (15.1%) of the control group, and the total incidence of the maternal adverse pregnancy outcomes (38.7%) in the observation group was significantly higher than that (20.8%) in the control group. In the observation group, the levels of BUN and UA of the women with the adverse neonatal outcomes were significantly higher than those of the women without the adverse neonatal outcomes, while the ultrasonic fetal venous blood flow parameters of the women with the adverse neonatal outcomes were significantly lower than those of the women without the adverse neonatal outcomes (all P<0.05). The areas under the curve of the BUN level, the UA level, the PSV value, the EDV value, the Vmax value, and the levels of BUN and UA combined with the values of PSV, EDV and Vmax of the women for predicting their adverse neonatal outcomes were 0.735, 0.760, 0.643, 0.809, 0.670 and 0.706, respectively. The sensitivity of the levels of BUN and UA combined with the values of PSV, EDV and Vmax of the women for predicting their adverse neonatal outcomes was 100.0%. Conclusion: The levels of BUN and UA of the pregnant women with PE complicated with FGR increase, and the values of the ultrasound parameters of venous catheter blood flow of the pregnant women with PE complicated with FGR decrease, and all of which have certain clinic guidance values for predicting the adverse neonatal outcomes of these women.

2024 Vol. 32　(10):　2391- [Abstract]（ 38 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

2024 Vol. 32　(10):　2400- [Abstract]（ 37 ） HTML (0 KB)  PDF  (0 KB)  ( 10 )

To detect the expression of p16/mcm2 in cervical exfoliated cells of patients with cervical lesions, and to explore the clinical values of p16/mcm2 and human papillomavirus (HPV) detections of patients for screening their cervical lesion. Methods: 1045 women who were screened for cervical cancer in the gynaecology outpatient clinic or ward of Xuzhou cancer hospital and met the included standard from May 2023 to October 2023 were selected as the study subjects. These women were given the p16/mcm2 immunocytochemistry double-staining and HPV detections. The women with the lesions of atypical squamous epithelial cells of unknown significance (ASC-US) or above by p16/mcm2 double-staining diagnosis or with the HPV16/18 positivity were given colposcopy, biopsy and pathological examinations. Results: The positive rate of p16/mcm2 increased in order of the women with HPV negative, of the women with low-risk HPV infection, of the women with the other 12 types of HPV positive and of the women with HPV16/18 positive (P=0.000). The positive expression of p16/mcm2 of the women with the positive other 12 types of HPV was significantly higher than that of the women with the negative HPV (OR=4.28, 95%CI 2.02-9.04). The positive expression of p16/mcm2 of women with positive HPV 16/18 was significantly higher than that of the women with the negative HPV (OR=76.64, 95%CI 36.05-162.93). The positive expression of p16/mcm2 of the women with positive HPV16/18 was significantly higher than that of the women with the positive other 12 types of HPV. The positive expression of the women increased with the severity of their cervical lesions (all P<0.05). The sensitivity of p16/mcm2 detection of the women for predicting their cervical lesions of CINⅠ, CINⅡ and CIN Ⅲ were 85.0%, 89.1% and 94.3%, respectively, and the positive predictive value of p16/mcm2 of the women for predicting their cervical lesions of CINⅠ, CINⅡ and CIN Ⅲ were 94.1%, 97.0% and 97.0%, respectively, and both of which of the women were significantly higher than those of HPV detection. Conclusion: There is a correlation between the positive p16/mcm2 double staining results of the women and their HPV infection, and both can be used for screening the cervical lesions of the women. Compared with that of HPV detection, the p16/mcm2 double staining detection has higher sensitivity and specificity, so the combined detections of p16/mcm2 double staining and HPV of the patients can be as the good application prospect of the cervical cancer screening method.

2024 Vol. 32　(10):　2411- [Abstract]（ 41 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

2024 Vol. 32　(10):　2419- [Abstract]（ 35 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )

2024 Vol. 32　(10):　2429- [Abstract]（ 48 ） HTML (0 KB)  PDF  (0 KB)  ( 8 )

To explore the clinical screening value of four-dimensional color ultrasound for fetal congenital heart disease (CHD) during the second trimester of pregnancy. Methods: The clinical data of 1500 pregnant women who had undergone prenatal CHD screening by four-dimensional color Doppler ultrasound in the hospital from March 2020 to September 2023 were selected as the research subjects retrospectively. The diagnosis of fetal CHD was based on the examination result of the neonatal echocardiography after delivery and the presence of CHD symptoms of the neonates during 6 months of follow-up, and the screening efficacy of four-dimensional color Doppler ultrasound for the fetal CHD was analyzed. Results: Among 1500 fetuses, 20 (1.3%) fetuses were diagnosed with CHD. Fourdimensional color Doppler ultrasound detected 17 fetuses with the true positive CHD, 1474 fetuses with the true negative CDH, 6 fetuses with the false positive CDH and 3 fetuses with the false negative CHD. The sensitivity, the specificity, the accuracy, the positive predictive value and the negative predictive value of the four-dimensional color Doppler ultrasound of the pregnant women for their fetal CHD were 85.0%, 99.6%, 99.4%, 73.9% and 99.8%, respectively. Among 20 fetuses with CHD, there were 6 cases with ventricular septal defect, 5 cases with double outlet right ventricle, 4 cases with tricuspid regurgitation, 3 cases with transposition of the great arteries and 2 cases with coarctation of the aorta. Four-dimensional color Doppler ultrasound detected 5 cases with ventricular septal defect, 5 cases with double outlet right ventricle, 4 cases with tricuspid regurgitation, 1 case with transposition of the great arteries and 2 cases with coarctation of the aortic arch. In the diagnosis of CHD by four-dimensional color Doppler ultrasound, there were 6 cases with misdiagnosed CHD, including 5 cases with atrioventricular valve color flow abnormality and 1 case with ventricular relaxation abnormality, and there were 3 cases with missed CHD, including 2 cases with transposition of the great arteries and 1 case with ventricular septal defect. Conclusion: Four-dimensional color Doppler ultrasound has higher screening effectiveness for the fetal CHD of the pregnant women during the second and the third trimester of pregnancy. The best examination timing of four-dimensional color Doppler ultrasound for the fetal CHD of the pregnant women is during the second trimester of pregnancy (13-28 gestational weeks), especially during 2228 gestational weeks, which can reduce the misdiagnosis and missed diagnosis of the fetal CHD.

2024 Vol. 32　(10):　2440- [Abstract]（ 44 ） HTML (0 KB)  PDF  (0 KB)  ( 7 )

To investigate the influence of the different delivery modes of primiparas on their short-term anterior pelvic function evaluated by the pelvic floor ultrasonography quantitatively. Methods: The clinical data of 102 primiparas who had undergone the pelvic floor examination by ultrasound from June 2022 to December 2023 were collected. According to the different delivery modes, these primiparas were divided into group A (58 primiparas with vaginal delivery) and group B (44 primiparas with cesarean section). The short-term anterior pelvic function of the primiparas in the two groups were evaluated quantitatively by pelvic floor ultrasound. The values of the pelvic floor ultrasound parameters and the incidence of abnormal anterior pelvic function of the primiparas were compared between the two groups. Results: There were no significant differences in the maternal age, the body mass index and the neonatal length of the primiparas between the two groups (P>0.05). There were no significant differences in the bladder neck distance (25.1±4.4 mm vs. 25.6±4.2 mm), the posterior bladder angle value (117.6±6.8 °vs. 118.2±7.5 °), the urethral tilt angle value (29.1±2.4 °vs. 28.2±2.5 °) of the primiparas between the two groups (P>0.05). The values of the maximum Valsalva ultrasound parameters, such as the bladder neck descent (27.17±7.38mm), the posterior bladder angle (132.91±10.57 °) and the urethral tilt angle (53.82±12.35 °), of the primiparas in group A were significantly higher than those (15.26±6.14mm, 124.93±9.18 °and 34.71±10.02°) of the primiparas in group B. The incidence of the cystocele (53.5%) of the primiparas in group A was significantly higher than that (27.3%) of the primiparas in group B, and the incidence of the internal urethral orifice dilatation (19.0%) of the primiparas in group A was significantly higher than that (4.6%) of the primiparas in group B (all P<0.05). Conclusion: The pelvic floor ultrasound can effectively and quantitatively evaluate the changes of the anterior pelvic structure and function of the primiparas with the different delivery modes, and the changes of the pelvic structure and function of the primiparas with vaginal delivery are greater than those of the primiparas with cesarean section.

2024 Vol. 32　(10):　2450- [Abstract]（ 43 ） HTML (0 KB)  PDF  (0 KB)  ( 10 )

The insulin-like growth factors (IGFs) signaling system is one of the key pathways that regulating the growth, development, and aging of the body. The signaling of IGFs is regulated by the insulin-like growth factor-binding proteins (IGFBPs). IGFBP5, as a member of the IGFBPs family, has the most conserved sequences among the members of the IGFBPs family across species yet, and which has the most diverse biological roles. The expression level and the functional role of IGFBP5 may differ in the different contexts. The results of several previous studies show that the elevated level of IGFBP5 may reduce the reproductive capacity of the body. However, the results of the current studies on the influence of the elevated IGFBP5 level of the body on their disorders of glucose-lipid metabolism and their development of diabetic complications are all still highly contradictory. In conclusion, IGFBP5 is a multifunctional protein with the strong background specificity in its effect and mechanism of action, which is capable of the exerting positive or negative regulatory effect in a specific space and time, through different pathways.

2024 Vol. 32　(10):　2459- [Abstract]（ 71 ） HTML (0 KB)  PDF  (0 KB)  ( 9 )