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| Influence of the different doses of vitamin D supplementation for infants with very low birth weight on their bone metabolism and physique indicators |
| 1.Hejiang County Hospital of Traditional Chinese Medicine, Luzhou, Sichuan Province, 646200; 2.Affiliated Hospital of Southwest Medical University, Luzhou |
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Abstract To analyze the influence of the different doses of vitamin D supplementation for infants with very low birth weight on their bone metabolism and physique indicators. Methods: A total of 85 infants with very low birth weight who were delivered in the hospital from January 2022 to December 2023 were selected and were divided into three groups by the simple random grouping method. 28 infants in group A were given 400 IU/d vitamin D supplementation for 4 weeks, 28 infants in group B were given 600 IU/d vitamin D supplementation for 4 weeks and 29 infants in group B were given 800 IU/d vitamin D supplementation for 4 weeks. The level of serum 25-hydroxyvitamin D (25-(OH)D), the levels of bone metabolism indicators, such as serum calcium (Ca), phosphorus (P) and alkaline phosphatase (AKP), the physique indicators values and the complication rate of the infants before and after intervention were compared between the three groups. Results: The levels of serum 25 (OH) D, Ca and AKP of the infants in the three groups after intervention had increased significantly, and the P level of the infants in group C after intervention had increased significantly (P<0.05). The levels of serum 25 (OH) D (66.73±9.68ng/ml) and P (2.05±0.24 mmol/L) of the infants in group C were significantly higher than those of the infants in the other two groups, and the AKP level (506.75±110.34 U/L) of the infants in group C was significantly lower than that of the infants in the other two groups (P<0.05). The Ca level (2.30±0.25 mmol/L) of the infants in group C had no significantly different from that of the infants in the other two groups (P>0.05). The serum 25 (OH) D level(58.48±10.23ng/ml) of the infants in group B was significantly higher than that (50.35±8.27ng/ml) of the infants in group A, and the AKP level (553.48±118.20U/L) of the infants in group B was significantly lower than that (591.41±123.10U/L) of the infants in group A (all P<0.05). There was no significant difference in the Ca and P levels of the infants between group B and group A (P>0.05). The ultrasound bone mineral density value of the infants in the three groups had increased significantly, and which (2934.55±127.78m/s) of the infants in group C was significantly higher than that of the infants in the other two groups (all P<0.05), and there was no significant difference in the ultrasound bone mineral density value of the infants between group B and group A (P>0.05). The height growth rate (0.93±0.35 cm/week) and the weight growth rate (15.08±2.49 g/week) of the infants in group C were significantly greater than those of the infants in the other two groups, and both of which of the infants in group B were significantly greater than those of the infants in group A (all P<0.05). The growth rate of head circumference (0.63±0.23 cm/week) of the infants in group C was significantly more than that of the infants in group A (P<0.05), but which of the infants had no significant difference between group B and group A (P>0.05). There were no significant differences in the incidences of the metabolic bone disease (0 vs. 3.6% vs.7.1%), the bronchial pulmonary dysplasia (13.8% vs. 17.9% vs. 17.9%) and the premature retinopathy (10.3% vs. 7.1% vs.7.1%) of the infants among the three groups (P>0.05). Conclusion: The different doses of vitamin D for treating the infants with very low birth weight can improve their bone metabolism and promote their physique development, and the high-dose vitamin D (800IU/d) has the most significant effect.
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