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| Anesthetic effect of the dizosin or remimazolam combined with propofol for the painless abortion of women and their influence on the serum central nervous system specific protein and interleukin-6 levels |
| 1.Jiangnan Hospital Affiliated to Zhejiang University of Chinese Medicine Affiliated Jiangnan Hospital (Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine), Zhejiang Province, 311200; 2.Enze Medical Center (Group) Enze Hospital |
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Abstract To compare the effect of the dizosin and remimazolam combined with propofol for the painless abortion of women, and to study their influence on the serum central nervous system specific protein (S100β) and interleukin-6 levels (IL-6) of the women. Methods: 90 women who wanted painless abortion voluntarily were selected as the study subjects and were randomly divided into two groups by random number table from June 2021 to December 2023. The women in group A were given remimazolam combined with propofol for the painless abortion, and the women in group B were given dizosin combined with propofol for the painless abortion. The anesthesia effects and the changes of the serum S100β and IL-6 levels of the women were compared between the two groups. Results: The analgesic effect of the women in group B was significantly better than that of the women in group A. The intraoperative blood oxygen saturation (98.25±3.13) %, the heart rate (77.71±7.98 times/min), the respiratory rate (17.26±1.76 times/min) and the mean arterial pressure (79.66±3.82 mmHg) of the women in group B were significantly higher than those (95.51%±3.10%, 70.46±7.12 times/min, 15.13±1.53 times/min and 76.37±3.89 mmHg) of the women in group A. The NRS score of the postoperative pain (2.05±0.54 points) of the women in group B was significantly lower than that (3.10±0.62 points) of the women in group A. The dosage of propofol (112.16±13.34 mg) of the women in group B was significantly less than that (181.95±20.12 mg) of the women in group A. The levels of the serum S100β (1.07±0.34 mu g/ml) and IL-6 (22.94±6.49) of the women in 24h after abortion of the women in group B were significantly lower than those (1.52±0.47μg/ml and 32.62±8.02 ng/L) of the women in group A. The incidence of adverse reactions (4.4%) of the women in group B was significantly lower than that (17.8%) of the women in group A (all P<0.05). Conclusion: Compared with those of remimazolam combined with propofol for the painless abortion of the women, the dizosin combined with propofol for the painless abortion of the women has the better anesthesia effect, which can not only alleviate the surgical pain of the women, but also can decrease the probability of their adverse reactions and alleviate their cognitive impairment.
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