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| Value of the ultrasound monitoring combined with the levels of blood urea nitrogen and uric acid of pregnant women with preeclampsia complicated with fetal growth restriction for predicting their adverse pregnancy outcomes |
| Chengde Central Hospital, Chengde, Hebei Province, 067000 |
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Abstract To explore the value of the ultrasound monitoring combined with the levels of blood urea nitrogen (BUN) and uric acid (UA) of pregnant women with preeclampsia (PE) complicated with fetal growth restriction (FGR) for predicting their adverse pregnancy outcomes. Methods: 106 pregnant women with PE from January 2020 to May 2023 were collected retrospectively, including 106 women complicated with FGR in observation group and 106 women without FGR in control group. The levels of BUN and UA, the values of peak systole velocity (PSV), peak diastolic velocity (EDV) and average maximum blood flow velocity (Vmax) of the venous catheter of the women were compared between the two groups. The adverse outcomes of the newborns and the pregnant women in the two groups were counted. Results: The levels of BUN (5.03±1.22mmol/L) and UA (435.54±52.13mmol/L) of the women in the observation group were significantly higher than those (4.01±1.30 mmol/L and 391.60±60.88 mmol/L) of the women in the control group. The values of PSV (0.85±0.12cm/s), EDV (0.78±0.11cm/s) and Vmax (0.81±0.13cm/s) of the women in the observation group were significantly lower than those (0.89±0.11 cm/s, 0.96±0.14 cm/s and 0.98±0.12 cm/s) of the women in the control group. The total incidence of the neonatal adverse outcomes (67.9%) in the observation group was significantly higher than that (15.1%) of the control group, and the total incidence of the maternal adverse pregnancy outcomes (38.7%) in the observation group was significantly higher than that (20.8%) in the control group. In the observation group, the levels of BUN and UA of the women with the adverse neonatal outcomes were significantly higher than those of the women without the adverse neonatal outcomes, while the ultrasonic fetal venous blood flow parameters of the women with the adverse neonatal outcomes were significantly lower than those of the women without the adverse neonatal outcomes (all P<0.05). The areas under the curve of the BUN level, the UA level, the PSV value, the EDV value, the Vmax value, and the levels of BUN and UA combined with the values of PSV, EDV and Vmax of the women for predicting their adverse neonatal outcomes were 0.735, 0.760, 0.643, 0.809, 0.670 and 0.706, respectively. The sensitivity of the levels of BUN and UA combined with the values of PSV, EDV and Vmax of the women for predicting their adverse neonatal outcomes was 100.0%. Conclusion: The levels of BUN and UA of the pregnant women with PE complicated with FGR increase, and the values of the ultrasound parameters of venous catheter blood flow of the pregnant women with PE complicated with FGR decrease, and all of which have certain clinic guidance values for predicting the adverse neonatal outcomes of these women.
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