To analyze the effects of the perioperative comprehensive heat preservation intervention in the operating room for women with cesarean section caused by placenta previa on the women in the short-term after operation. Methods: A total of 82 pregnant women with placenta previa who wanted cesarean section in the hospital were selected and were divided into the control group (41 women with the routine nursing intervention in the operating room) and the observation group (41 women with the perioperative comprehensive heat preservation intervention in operating room) by the random number table method from January 2020 to December 2023. The body temperature change, the operation-related indicators values, the homeostasis status, the shivering situation evaluated by Bedside Shivering Assessment Scale (BSAS), the occurrence of hypothermia and chills, and the nursing satisfaction evaluated by Newcastle Satisfaction Nursing Scale (NSNS) of the women were compared between the two groups. Results: After the perioperative interventions, the temperature after the anesthesia effect at (T1) (36.62±0.33 ℃), after fetal giving birth(T2)(6.55±0.26℃) and at the end of the surgery (T3) (36.50±0.41℃) of the women in the observation group were significantly higher than those (35.71±0.29℃, 35.37±0.29℃and 35.31±0.35℃) of the women in the control group. The levels of blood glucose (7.52±1.50 mmol/L) and the blood lactic acid (1.44±0.51 mmol/L) of the women in the observation group at T3 significantly were lower than those (8.65±1.75 mmol/L and 1.87±0.39 mmol/L) of the women in the control group. The pH value (7.35±0.04) of the women in the observation group was significantly higher than that (7.30±0.05) of the control group. The intraoperative blood loss (481.4±35.7ml) and the anesthesia recovery time (56.4±6.2 min) of the women in the observation group were significantly lower than those (691.6±51.8ml and 75.4±5.4 min) of the women in the control group. The blood oxygen saturation (97.7±1.2%) of the women in the observation group was significantly higher than that (94.7±1.4%) of the women in the control group. The maternal BSAS score (1.54±0.28 points) and the incidence of maternal cold chills severity (4.9%) of the women in the observation group were significantly lower than those (2.01±0.37 points and 22.0%) of the women in the control group. The maternal care satisfaction (97.6%) of the women in the observation group was significantly higher than that (82.9%) of the women in the control group (all P<0.05). Conclusion: The perioperative comprehensive heat preservation intervention in operating room for the women with placenta previa can effectively help to maintain their stable body temperature during cesarean section, can reduce their intraoperative blood loss and shorten their anesthesia recovery time, and which is also beneficial for maintaining the blood oxygen and homeostasis and reducing the occurrence of the maternal shivering and chills, and with the higher satisfaction.