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| Effects of Yinzhihuang oral liquid combined with blue light irradiation for treating newborns with pathological jaundice on their levels of bilirubin and myocardial impairment indicators |
| Western Theater General Hospital, Chengdu, Sichuan Province, 610000 |
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Abstract To investigate the effects of Yinzhihuang oral liquid combined with blue light irradiation for treating newborns with pathological jaundice on their levels of bilirubin and myocardial impairment indicators. Methods: 90 newborns with pathological jaundice who were treated in the hospital from January to December 2023 were selected as the study subjects. These newborns were divided into two groups (45 cases in each group) by the random number table. The newborns in the two groups were treated with blue light irradiation, while the newborns in the observation group were treated with Yinzhihuang oral liquid additionally. The clinical effect, the levels of bilirubin total bilirubin (TBIL), direct bilirubin (DBIL) and the indirect bilirubin (IBIL), the levels of inflammatory factors tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6), the levels of myocardial impairment indicators, such as creatine kinase isoenzyme (CK-MB) and cardiac troponinc (cTnI), the levels of neurological impairment indicators, such as amyloid beta (Aβ), neuron specific enolase (NSE) and TBIL to albumin ratio (B/A), and the adverse reactions rate of the newborns were compared between the two groups. Results: The therapy efficacy (93.3%) of the newborns in the observation group was significantly higher than that (77.8%) of the newborns in the control group. The meconium emptying time, the jaundice subsided time, and duration of the hospital stay of the newborns in the observation group were significantly shorter than those of the newborns in the control group (all P<0.05). After 1 week of treatment, the levels of serum TBIL, DBIL, IBIL, TNF-α, CRP, IL-6, CK-MB, cTnI, Aβ, NSE, and B/A of the newborns in the two groups had decreased significantly, and which of the newborns in the observation group were significantly lower than those of the newborns in the control group (all P<0.05). The incidence of the adverse reactions (6.7%) of the newborns in observation group had no significantly different from that (11.1%) of the newborns in the control group (P>0.05). Conclusion: Yinzhihuang oral liquid combined with blue light irradiation for treating the newborns with pathological jaundice can increase the effectiveness, and which can promote their jaundice regression, decrease their levels of bilirubin and cTnI, and protect their myocardial cells and nerve function, and it is conducive to the prognosis of the newborns.
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