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| Research progress of nitric oxide for treating neonate with persistent pulmonary hypertension |
| 1.Hainan People’s Hospital（Hainan Hospital Affiliated to Hainan Medical University）, Haikou, Hainan Province, 570100；2.The Second Affiliated Hospital of Hainan Medical University，Haikou |
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Abstract Neonatal persistent pulmonary hypertension (PPHN) is a common critical disease during the neonatal period, with the mortality rate of 20.6%. At present, the main drug treatment for the neonatal PPHN is the application of the pulmonary vasodilator. Nitric oxide, as a selective pulmonary vasodilator, has been used as the preferred drug for the treatment of the neonatal PPHN, but nitric oxide also has certain limitations. This paper mainly reviews the advantages and disadvantages of NO for treating the neonatal PPHN, as well as the clinical effect and the existing problems of NO combined with other drugs for treating the neonatal PPHN.
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