2020 Vol. 28　(10):　1518-1522 [Abstract]（ 598 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

To identify the proteomics of endometrium in patients with polycystic ovarian syndrome (PCOS) by liquid chromatography tandem mass spectrometry (LC MS/MS) technology, and to find proteins expressed differentially and their associated biological pathways. Methods: Endometrial biopsy tissue samples were divided into PCOS group (n =15) and non-PCOS group (n=12). After these tissues were processed, the LC-MS / MS technology was used to detect the solution samples, then the offline data was statistically and bioinformatically analyzed. Results: A total of 7285 proteins were identified, of which 6920 proteins were expressed in both groups. In the PCOS group, the expression of 290 proteins had up regulated (FC≥ 2.0, P<0.05), and the expression of 141 proteins had down regulated (FC≤0.5, P<0.05). KEGG enrichment analysis of these proteins had showed that differentially expressed proteins on the tryptophan metabolic pathway, the tyrosine metabolic pathway, and the phenylalanine metabolic pathway were significant enriched, of which tryptophan metabolism was the most significant. The differential proteins involved Kynurenine 3-monooxygenase, AOX1, Amine oxidase, HCG23341, Amine oxidase (flavin containing) A, Amine oxidase (flavin containing) B, 2 oxoglutarate dehydrogenase. Conclusion: There is abnormal amino acid metabolism in protein expression levels in the endometrium of the patients with PCOS, which may lead to immune homeostasis, the changes of proliferative function and energy supply of cell, and may be associated with pathogenic mechanism of PCOS.

2020 Vol. 28　(10):　1526-1528 [Abstract]（ 393 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To investigate the incidence and the risk factors of neonatal asphyxia, and to explore the preventive measures. Methods: The cluster sampling was used to select 10 medical institutions from May to August 2019, the live birth and maternity in these medical institutions during this period were selected as objects. A unified questionnaire was used to investigate the pregnant situation and demographic data of women, and Logistic regression model was used for multivariate analysis. Results: A total of 51 of 954 newborns had asphyxia. The incidence of newborn asphyxia was 5.4%, which included 43 cases (84.3%) with mild asphyxia, 8 cases (15.7%) with severe asphyxia, and 4 cases (7.8%) with deaths related to asphyxia. Logistic regression model analysis showed that infection during pregnancy, <37 gestational weeks, placenta previa, amniotic fluid pollution, intrauterine distress, and uterine atony were independent risk factors for neonatal asphyxia, and annual household income ≥ 30000 were independent protective factor. Conclusion: The incidence of neonatal asphyxia is high in Hangzhou city, and there are many risk factors affecting neonatal asphyxia, so perinatal health care should be strengthen, complications during pregnancy should be actively prevented, the progress of labor should be closely observed, and emergency skills should be improved, so as to reduce the incidence of neonatal asphyxia.

2020 Vol. 28　(10):　1535-1538 [Abstract]（ 273 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

To summarize and analyze the results of external quality assessment(EQA) and the on-spot inspection of the free pre-pregnancy physical examination in Inner Mongolian Autonomous Region, and to provide evidences for continuous improvement of quality management and technical service of laboratories levels. Methods: In 2 times EQA of one year, controls of 31 items in 8 categories were distributed to the participated laboratories, and all returns from these laboratories were evaluated and statistical analyzed. The results of technical survey and detection of blind samples involved in the on-spot inspection were also analyzed. Results: During 2013-2019, there were 105-109 laboratories participated in EQA, the excellent rate had increased from 6.2% to 66.0%, and the total excellent and good rate had increased from 46.0% to 97.2%. The percent of pass of 11 items less than 80% in 2013, which had increased over 85% in recent tow years. The proportion of enzyme-linked immunsorbent assay（ELISA）and chemiluminescence immunoassay（CLIA）used for detecting the serological markers of hepatitis B virus had raised obviously. The percent of pass of blind samples detection had improved remarkably in recent three years, which all were over 85% in 2019. Conclusion: Based on the integrated working pattern of EQA, on-spot inspection, professional training, notification, and appraisal of performance for 7 years, the quality indicators of laboratories have improved remarkably, which help to discover the quality problem and to provide evidence for promoting comprehensive quality management.

2020 Vol. 28　(10):　1543-1547 [Abstract]（ 265 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

To explore the value of the levels of serum monocyte chemoattractant protein-1 (MCP-1), omentin, and endostatin (ES) level for diagnosing polycystic ovary syndrome (PCOS). Methods: 96 women with PCOS were selected in group A, 68 women with Cushing syndrome were selected in group B, and 36 healthy volunteers were selected in group C from March 2018 to March 2019. The serum levels of MCP-1, omentin, and ES of women were compared among the three groups. The value of the serum MCP-1 level, omentin level, or ES level only, and the value of combined the serum MCP-1 level, omentin level, and ES level for diagnosing PCOS were analyzed. The ROC curve was used to analyze the evaluation efficiency. Results: The serum levels of MCP-1 and omentin of women in group A were significant lower than those of women in group B and C, but the serum ES level of women in group A were significant higher (P＜0.05). The serum levels of MCP-1 and omentin of women in group B were significant lower than those of women in group C, but the serum level of ES of women in group B were significant higher (P＜0.05). The sensitivity of combined McP-1 level, omentin level, and ES level for diagnosing PCOS was significant lower than that of McP1 level, omentin level, or ES level only, but the specificity of the combined of McP-1 level, omentin level, and ES level for diagnosing PCOS was significant higher (P＜0.05). The area under ROC curve of McP-1 level, omentin level, or ES level only for diagnosing PCOS was 0.902, and that of the combined of McP1 level, omentin level, and ES level for diagnosing PCOS was 0.889 (P>0.05). Conclusion: The combined of McP-1 level, omentin level, and ES level for diagnosing PCOS can improve the sensitivity, the specificity, and the accuracy effectively.

2020 Vol. 28　(10):　1552-1555 [Abstract]（ 317 ） HTML (0 KB)  PDF  (0 KB)  ( 28 )

2020 Vol. 28　(10):　1560-1564 [Abstract]（ 355 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

To investigate the effect of gonadotropin-releasing hormone α (GnRH-α) and gestrinone for treating women with ovarian endometriosis cysts after ovarian cystectomy, and to study their influence on the levels of serum hormone, assisted T(Th) cytokines, anti-Mullerian hormones (AMH), and the effect of tumor marker CA125. Methods: 90 women who had experienced ovarian endometriosis cystectomy were selected and were divided into observation group and control group (45 cases in each group) according to the random number table method from January 2016 to January 2018. Then the women in the observation group were given GnRH-α, and the women in the control group were given gestrinone. The clinical efficacy of the women in the two groups was analyzed. The levels of serum follicle stimulating hormone (FSH), estradiol (E2), FSH/Luteinizing Hormone (LH), Th cytokine, AMH, and CA125 of the women in the two groups were compared before and after treatment. And the recurrence rate and pregnancy rate of women in the two groups were followed up for 1 year. Results: The total effective rate of women in the observation group was 97.8%, which was significant higher than that (80.0%) of women in the control group. After treatment, the levels of serum FSH, E2, FSH/LH, and CA125 of women in the two groups had decreased significantly, while the level of AMH had increased significantly, and which’s changes of women in the observation group was significant more than those of women in the control group (P＜0.05). The levels of interleukin-2 (IL-2) and interferonγ(IFN-γ) of women in the observation group were significant higher than those of women in the control group, but the levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) of women in the observation group were significant lower. The recurrence rate of women in the observation group was 6.78%, which was significant lower than that (20.0%) of women in the control group. The pregnancy rate of women in the observation group was 60.0%, which was significant higher than that (40.0%) of women in the control group (all P＜0.05). Conclusion: The therapeutic effect of GnRH-a for adjuvant treating women after ovarian endometriosis cystectomy is better than that of gestrinone treatment, which can significantly improve the levels of sex hormones, AMH and CA125, can restore the balance of Th cell factor, can reduce the recurrence rate, and can increase the pregnancy rate.

2020 Vol. 28　(10):　1570-1573 [Abstract]（ 336 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

To investigate the efficacy of hysteroscopy for treating incomplete abortion of women with uterine scar pregnancy (USP). Methods: From January 2015 to March 2017, 68 women with USP after cesarean section and incomplete abortion were selected in this study, which included 38 women who underwent hysteroscopy after bilateral uterine artery embolization were in the observation group, and 30 women who underwent traditional uterine clearance and adequate hemostasis after bilateral uterine artery embolization were in the control group. The operation situation and pregnancy outcomes of women were compared between the two groups. Results：There were no significant different in the operation time, duration of abdominal pain, and later pregnancy outcomes of women between the two groups (P>0.05). In the observation group, 1 woman had been converted to laparoscopic operation, while in the control group, 8 women had been converted to laparoscopic operation and 1 woman had been converted to open operation. The success rate of operation, the hospital stay time after operation, the amount and the duration of bleeding after operation, of women in the observation group were 97.4%, 4.3 days (4-8d), 21.5ml(5-50ml), and 4.7 days (2-12d), respectively, which were significant lower than those of women in the control group (P＜0.05). The recovery time of HCG level of women after operation in the observation group was 10.7%, which was significant lower than that of women in the control group (P＜0.05). There were no significant difference in the other indicators of pregnancy outcomes between the two groups (P>0.05). Conclusion: Compared to the traditional curettage, hysteroscopy with bilateral uterine artery embolization is an ideal method for treating incomplete abortion of scar pregnancy, which has fewer traumas, less bleeding, higher success rate, faster recovery, and lower rate of spontaneous abortion in next pregnancy.

2020 Vol. 28　(10):　1578-1582 [Abstract]（ 310 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

To investigate the effect of intravenous anesthesia of etomidate combined with propofol for treating women on their postoperative recovery quality and inflammatory factors，such as (interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) after laparoscopic hysterectomy. Methods: 114 women who wanted laparoscopic hysterectomy were enrolled and randomly divided into three groups from January 2017 to September 2019. 45 women in group A had received etomidate combined with propofol for intravenous anesthesia, 36 women in group B had received propofol for intravenous anesthesia, and 33 women in group C had received etomidate for intravenous anesthesia. The values of diastolic blood pressure, systolic blood pressure, heart rate, recovery time, extubation time, recovery room retention time, and levels of IL-6, CRP, and TNF-α, and adverse reaction rate of women were compared among the three groups. Results: At T1, the diastolic blood pressure, systolic blood pressure, and heart rate of women in group A were 80.21±9.92 mmHg, 139.64±8.62 mmHg, and 87.34±5.89 time/min, which were significant lower than those in group B and C (P＜0.05). At T2-T3, there were no significant different in the values of diastolic blood pressure, systolic blood pressure, and heart rate of women among the 3 groups (P>0.05). Wake time, extubation time, stay time in recovery room of women in group A were siginificant shorter than those of women in group B and C (P＜0.05). The serum levels of IL-6, CRP and TNF-α of women in the three groups at T3 were significant lower than those at T0, and those of women in group A were siginificant lower than those of women in group B and C (P＜0.05). The rate of adverse reaction of women in group A was 4.4%, which was significant lower than that (33.3%) of women in group B or that (15.2%) of women in Group C (P＜0.05). Conclusion: Intravenous anesthesia by etomidate combined with propofol for treating women during laparoscopic hysterectomy can improve postoperative quality of anesthesia awakening of women and can inhibition of inflammatory factor response effectively, and has better safety.

2020 Vol. 28　(10):　1587-1590 [Abstract]（ 540 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

To investigate the occurrence of fetal chromosomal abnormalities of elderly women (≥ 35 years old when expected date of confinement), and to provide evidence for selecting more appropriate technique of prenatal screening or prenatal diagnosis for elderly pregnant women. Methods: A retrospective analysis was conducted on the data of 4224 unifetal pregnant women who had experienced prenatal diagnosis due to elderly age from 2008 to 2018. And they were divided into different groups according to the preganant women age, whether with abnormal ultrasound soft markers (USM), whether with abnormal serum screening index during the second trimester of pregnancy, and whether with abnormal noninvasive prenatal testing (NIPT) high-risk. The distribution of fetal chromosomes was compared among these groups, and the significance of clinical screening was analyzed. Results: Among the 4224 elderly pregnant women, there were 321 cases (7.6%) fetuses with chromosome abnormality, which ingcluded 274 cases (6.5%) had chromosome aneuploidy, and it accounted for 85.36% of the women with abnormal karyotypes. There were 180 cases (4.26%) with trisomy 21 in 321 fetuses with chromosome abnormality, which accounted for 56.1% fetuses with abnormal karyotypes. And there were 91 cases (2.15%) with hromosome polymorphism. There were significant different in the incidences of fetal chromosomal abnormalities, chromosomal aneuploidy, and trisomy 21 among different ederly pregnant women (P＜0.05), but which had no significant different among pregnant women with ≥ 41 years old. When the abnormal USM number of fetus increased, the incidences of fetal chromosomal abnormalities, aneuploid, or trisomy 21 of ederly pregnant women had increased (P＜0.05). The incidence of chromosomal abnormalities or chromosomal aneuploidy of fetus with abnormal USM and single umbilical artery was the highest, and that of fetus with abnormal USM and lateral ventricle broadening was the second highest. The incidence of trisomy 21 of fetus with lateral ventricle broadening was the highest, and which of fetus with incrassation of NF was the second highest. The incidence of chromosomal abnormalities of fetus with high risk of trisomy 21 by NIPT was the highest. Conclusion: The pregnancy outcomes of ederly pregnant women without other complication are good. If the age of pregnant women before delivery is less than 40 years old, and has antenatal diagnostic contraindications or has precious fetus, STSS and NIPT combined with USM screening guided by doctor should be performed. Ederly pregnant women with uniumbilical artery, lateral ventricle broadening, or NF thickening, especially with abnormal USM, high risk of STSS or NIPT, or ≥41 years old, it is recommended to sign informed consent before invasive prenatal diagnosis.

2020 Vol. 28　(10):　1596-1600 [Abstract]（ 311 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

To investigate the application value of virtual touch quantification (VTQ) technique for evaluating infertility of man with varicocele. Methods: 120 infertile men with varicocele were selected in study group from November 2016 to November 2019, and the normal men with normal ultrasound and semen who wanted physical examination were selected in control group during the same time. The sperm concentration and motility, testicular volume, and transverse shear wave velocity (SWV) of men in the two groups were measured. The correlation of SWV value with semen quality and testicular volume was analyzed. Results: The sperm concentration and motility of men in the study group were significant lower than those of men in the control group. The volume of left testis of men in the study group was significant smaller than that of their right testis and the men in the control group (P＜0.05). The sperm concentratio of men with worse varicocele was significant less, their motility of sperm was significant lower, and their left testicular volume was significant smaller (P＜0.05). The SWV value of left testis of the men in the study group was significant lower than that of men in the control group (P＜0.05). SWV value was positively correlated with the sperm concentration, motility and testicular volume (P＜0.05). Conclusion: The testicular SWV measured by VTQ may be an indirect index for evaluating the volume and tissue hardness of testicular, and semen quality of infertility men with varicocele. 

2020 Vol. 28　(10):　1606-1608 [Abstract]（ 301 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

To analyze the value of transvaginal three-dimensional ultrasound (TTDU) combined with anti-Mullerian hormone (AMH) level for evaluating ovarian reserve function. Methods: 120 women who underwent prenatal examination from April 2017 to  June 2019 were collected retrospectively and were divided into group A (women with premature ovarian failure), group B (women with ovarian reserve function decreases), and group C (women with normal ovarian reserve function) according to ovarian reserve function (ORF). The parameters by TTDU, and the levels of sex hormone and AMH of women were compared among the three groups. The correlation between ultrasound parameters and AMH and sex hormone levels, and their values for diagnosing ORF were analyzed. Results: The level of FSH or LH of women in group A was the highest, but that of women in group C was the lowest (P＜0.05. There were no significant different in P and PRL levels of women among the three groups (P＜0.05).There was no significant difference in P and PRL levels among groups (P>0.05). The ultrasound parameter, such as AFC, or the value of OV,VI,FI or VFI, or AMH level of women in group A was the lowest, but that of women in group C was the highest (P＜0.05). AFC, and the values of OV, VI, FI and VFI were positively correlated with AMH level (P＜0.05). The sensitivity, the specificity, and the accuracy of ultrasound parameters combined with MAH level for evaluating ORF were 94.4%, 87.7%, and 90.4%, respectively, which were significant superior to those of ultrasound parameter or MAH level alone (P＜0.05). Conclusion: The ultrasound parameters by TTDU combined with MAH level for evaluating ORF has good value.

2020 Vol. 28　(10):　1613-1616 [Abstract]（ 341 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To analyze the value of transabdomen ultrasound (TAS) and transvaginal ultrasonography (TVS) for diagnosing cervical ectopic pregnancy. Methods: 80 patients with suspected cervical ectopic pregnancy were selected for analysis, among which, 26 women were examinated by TAS alone, 28 women were examinated by TVS alone, and 26 women were examinated by TAS combined with TVS. The pathological examination result was as the gold standard of diagnosis, the effect of diagnosing cervical ectopic pregnancy and the characteristics of misdiagnosis and missed diagnosis were compared between TAS and TVS. Results: TAS combined with TVS had the highest detection rate (90.9%), followed by TVS (76.0%), and TAS had the lowest detection rate (65.2%). The missed diagnosis of TAS was associated with insufficient display of liquid dark area in uterine and rectal lacunae, and low display rate of fluid dark area in intraabdominal mobility. The missed diagnosis and misdiagnosis of TVS were mainly caused by patients with peritoneal effusion or by inadequate estimated blood loss in patients with ruptured ectopic pregnancy. ROC curve analysis showed that the area under the ROC curve of TAS combined with TVS, TAS alone, or TVS alon for diagnosing cervical ectopic pregnancy were 0.778, 0.648 and 0.611, respectively. Conclusion：TVS combined with TAS for diagnosing cervical ectopic pregnancy has high accuracy rate, which can decrease the rate of missed diagnosis, and can provide fast and accurate data for supporting clinical practice.

2020 Vol. 28　(10):　1621-1623 [Abstract]（ 364 ） HTML (0 KB)  PDF  (0 KB)  ( 30 )

To investigate the relationship between single nucleotide polymorphisms of Toll-like receptor 3 (TLR3) gene of women and the rate of recurrent spontaneous abortion (RSA). Methods: 305 women with RSA were selected in study group, and 200 normal pregnant women were selected in control group from January 2015 to January 2019. The polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) was used for detecting the genes polymorphism on rs 5743305 and rs 3775290 TLR3 locus in peripheral blood of these women. The genotype distribution differences between the two groups were observed. The relationship between TLR3 genotypes of rs5743305 and rs 3775290 locus and RSA susceptibility or ACA antibodies (ACA-IgM, ACA-IgG) was analyzed. Results： In the study group, AA genotype (54.10%) and A allele (66.39%) of rs5743305 locus of women were the main, and CC genotype (44.92%) and C allele (58.36%) of rs 3775290 locus of women were the main. The levels of ACA-IgM and ACA-IgG of AA genotype on rs5743305 locus and CC genotype on rs 3775290 locus were 15.24±6.19 and 15.34±5.98, respectively, which were siginificant higher than those of other genotypes (P＜0.05). Logistic regression analysis showed that women with rs5743305 locus carrying AA genotype and rs 3775290 locus carrying CC genotype had significant higher risk of RSA (P＜0.05). Conclusion: The women with rs5743305 locus carrying AA genotype and rs 3775290 locus carrying CC genotype are included in RSA susceptible population.

2020 Vol. 28　(10):　1628-1631 [Abstract]（ 289 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

To observe the differences of uterine artery blood flow and serological markers of pregnant women with uterine atony. Methods: 60 pregnant women with uterine atony were selected in study group from March to February 20-18, 216, and 60 normal pregnant women were selected in control group during the same period. The levels of placental growth factor (PLGF) and vascular endothelial growth factor-1 (VEGFR-1), sEng, and adiponectin of women were compared between the two groups. The correlation between uterine artery flow values and serological indicators of pregnant women with uterine contraction was analyzed. Results: The levels of S/D, RI and PI of women in the study group were 2.83±0.31, 1.21±0.22, and 0.78±0.15, respectively, which were significant higher than those (1.75±0.23, 0.68±0.17, and 0.37±0.11, respectively) of women in the control group (t=-21.672, -14.766, -17.073), but the levels of PLGF and PLGF/sEng of women in the study group were 225.29±12.98pg/ mL and 35.19±6.24, which were significant lower than those in the control group (P<0.001). The levels of sEng and adiponectin were 6.98±1.02pg/ml and 16.35±2.11 g/ml, which were significant higher than those of women in the control group (P<0.001). The value of uterine artery blood flow of pregnant women with uterine atony was negative correlated with PLGF and PLGF/sEng levels (r=-0.475, -0.484, -0.449, -0.475, 0.532, -0.398, P＜0.05), but was positive correlated with sEng and adiponectin levels (r=0.502, 0.573, 0.512, 0.527, 0.433, 0.423, P<0.05). Conclusion: The uterine artery blood flow value of pregnant women with uterine atony is high, which is closely related to serum PLGF, PLGF/sEng, sEng and adiponectin levels.

2020 Vol. 28　(10):　1636-1638 [Abstract]（ 320 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

To investigate the ultrasonographic characteristics of uterine incision diverticulum (UID) inspected by transvaginal three-dimensional ultrasound (TTDU) after cesarean section, and to analyze its diagnostic value. Methods: The data of 350 women with suspected uterine incision diverticulum from October 2016 to December 2018 were collected retrospectively. The length, width, depth, thickness of incision muscle layer, shape of diverticulum (fissure liquid dark area, cystic liquid dark area, wedge liquid dark area) and other ultrasonographic features of UID of these women were observed by TTDU. And these women were divided in to group A and B according to the existence of clinical symptoms. The difference of sonographic features of women was observed between the two groups. Based on the result of diagnosd by hysteroscopy, the sensitivity and specificity of TTDU were analyzed. Results: There were 246 women with UID by TTDU, which included 103 women with clinical symptoms in group A and 143 women without clinical symptoms in group B. The length, width, depth, and incision myome thickness of UID of women in group A were 8.92±2.35 mm, 10.95±3.67mm, 5.87±1.79mm, and 3.25±1.03mm, respectively, which were significant higher than those of women in group B (P＜0.05). In group A, the rate of fissure-like dark areas (47.6%) of women was the main, but in group B, the rate of cystic and wedge-shaped liquid dark areas (93.20%) was the main (P＜0.05). The area under ROC curve (AUC) of UID by TTDU was 0.786 (95% CI: 0.6850.887, P=0.000), which’s sensitivity and specificity were 77.1% and 80.0%. Conclusion: TTDU used for diagnosing UID after cesarean section has high clinical value.

2020 Vol. 28　(10):　1643-1645 [Abstract]（ 321 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

To investigate the expression and significance of chemokine receptors 4 (CXCR 4) and stromal cell derived factors-1of infertility women with endometriosis. Methods: From December 2016 to May 2019, 164 women with endometriosis were included and were divided into two groups according to whether complicated with infertility, and 50 women with uterine myoma who underwent surgical treatment during the same time were selected in control group. The levels of SDF-1, CXCR4, MMP-9, and VEGF of women were compared among the groups, and the relationship between the expression of the levels of SDF-1 and CXCR4 and endometriosis complicated with infertility was analyzed. Results: The levels of SDF-1, CXCR4, MMP-9, and VEGF of infertility women with endometriosis were significant higher than those of women in the control group (P＜0 05). Correlation analysis showed that the expression levels of SDF-1 and CXCR4 were positively correlated with the expression levels of MMP-9 and VEGF (r=0.683, 0.701, 0.695, 0.674). The levels of SDF-1, CXCR4, MMP-9, and VEGF of infertile women with endometriosis were significant higher than those of women without infertile. Conclusion: CXCR4 may be lead to the the occurrence of infertility process of women with endometriosis by involving in endometrial proliferation and invasion.

2020 Vol. 28　(10):　1650-1653 [Abstract]（ 335 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

To investigate the efficacy and safety of tenofovir for blocking hepatitis B virus intrauterine transmission of pregnant women. Methods: the data of 446 pregnant women with hepatitis B were conlected retrospectively. 446 women from January 2011 to December 2014 were given routine intervention in control group, and 591 pregnant women from January 2015 to December 2018 in observation group were given tenofovir from 24-28 gestational weeks. Serum HBV DNA load, perinatal adverse reaction rate, situation of neonatal growth and development (length, head circumference, and body mass) and rate of high infant viral load of infants in the two groups were observed. Results: There was no significant difference in serum HBV DNA load of women before treatment between the two groups (P>0.05). The serum HBV DNA load of women in the observation group before delivery was (3.21±0.14)×108 copy/ml, which was significant lower than that ((7.14±1.09)×108 copy/ml) of women in the control group (P＜0.05). The incidence of adverse reaction during the perinatal period of women in the observation group was 1.7%, which was significant lower than that (3.8%) of the control group (all P＜0.05). There were no significant different in the length, head circumference, and body mass of the newborns between the two groups (P>0.05). The positive rate of high viral load of newborns in the control group was 0.7%, which was significant higher than that (0%) in the observation group (P＜0.05). Conclusion: Tenofovir used for treating the pregnant women with hepatitis B during pregnancy can effectively reduce the rate of mother-to-child transmission of hepatitis viru B, reduce the high viral load of infants, and has little adverse effect on the fetus, which is worthy of clinical application.

2020 Vol. 28　(10):　1658-1660 [Abstract]（ 343 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To analyze blood flow characteristics of uterine artery of pregnant women with primary or secondary preeclampsia. Methods：The pregnant women with pre-eclampsia were selected in study group, and were divided in group A (women with primary pre-eclampsia) and group B (women with secondary preeclampsia). The normal pregnant women were selected in control group. The Color doppler ultrasound was used to examine uterine artery blood flow, and the differences of uterine artery blood flow index, such as S/D, RI, PI value and the incidence of V-shaped incision of the women in the two groups were measured. The relationship between uterine artery blood flow and the severity of preeclampsia was analyzed. Results：The values of S/D, RI, and PI, and the incidence of V-shaped cutting of uterine artery of women in study group were significant higher than those of women in the control group (P＜0.05). The values of S/D and RI of women in group B were significant higher than those of women in group A (P＜0.05), there were no significant difference in the values of PI and V-shaped cutting of uterine artery between group A and B (P>0.05). In group A, the values of S/D, RI, and PI of women with severe preeclampsia were significant higher than those of women with mild preeclampsia. In group B, the values of S/D, RI, and PI, and the incidence of V-shaped cutting of uterine artery of women with severe preeclampsia were significant higher than those of women with mild preeclampsia (all P＜0.05). The values of S/D and RI, and the incidence of V-shaped cutting of uterine artery of women with mild preeclampsia in group A had no significant different from those of women with mild preeclampsia in group B (P>0.05). The values of S/D and RI of women with severe preeclampsia in group B were significant higher than those of women with severe preeclampsia in group A (P＜0.05). The PI value and the incidence of V-shaped cutting of uterine artery of women with severe preeclampsia in group A had no significant different from those of women with severe preeclampsia in group B (P>0.05). The independent risk factor of the primary severe preeclampsia was the RI value of uterine artery, and the independent risk factors of the secondary severe preeclampsia were the S/D and RI values of uterine artery (P＜0.05), and the PI value of uterine artery was no correlation with the onset and recurrence of women with primary or secondary severe preeclampsia (P>0.05). Conclusion：The uterine artery blood flow resistance of pregnant women with primary or secondary preeclampsia is high, and associate with severity of preeclampsia. The pregnant women with severe secondary preeclampsia have the most obvious increasing of uterine artery blood flow resistance.

2020 Vol. 28　(10):　1665-1668 [Abstract]（ 329 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To investigate the expression of microRNA-26a-5p (miR-26a-5p) in plasma and placenta of pregnant women with preeclampsia, and to study its correlation with the severity of preeclampsia. Methods: 122 pregnant women with preeclampsia were enrolled in study group, and 61 normal pregnant women were selected in control group. The values of systolic pressure (SP) and diastolic pressure (DP), the levels proteinuria, plasma albumin, and the expression of microRNA-26a-5p in plasma and placenta of women were measured and compared between the two groups. The expression of microRNA-26a-5p in plasma and placenta tissues was compared among women with different severity of preeclampsia. Pearson correlation was used to analyze the correlation between the expression of microRNA-26a-5p of pregnant women with preeclampsia and their clinicopathological characteristics. Results: The values of SP and DP, proteinuria level, and the miR-26a-5p level in plasma and placenta tissues of women in the observation group were significant higher than those of women in the control group, but the plasma albumin level of women in the study group was significant lower. The miR-26a-5p level in plasma and placenta tissues of women with severe preeclampsia was significant higher than that women with preeclampsia (all P＜0.05). The miR-26a-5p level in plasma and placenta of pregnant women with preeclampsia was positively correlated with their values of SP and DP, and their proteinuria level, but was negatively correlated with their plasma albumin level (P＜0.05). Conclusion: miR-26a-5p level in plasma and placental tissues of pregnant women with preeclampsia is high, and it is related to the severity of preeclampsia, which may be used as a new molecular target for diagnosing and treating preeclampsia.

2020 Vol. 28　(10):　1673-1675 [Abstract]（ 275 ） HTML (0 KB)  PDF  (0 KB)  ( 33 )

2020 Vol. 28　(10):　1680-1684 [Abstract]（ 305 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

To observe the effect of sufentanil for preventive analgesia during cesarean section, and to study its influence on the maternal analgesic VAS score, and the levels of blood glucose and cortisol. Methods: From February 2017 to June 2018, 80 women with cesarean section were divided into study group and control group (40 cases in each group). The stress indexes, such as hemodynamic, blood glucose and cortisol, and VAS scores during perioperative period of women were compared between the two groups. Results: MAP (87.47±3.75mmHg), HR (81.0±5.1 times/min), blood glucose level (4.23±0.95mmol/L), cortisol level (362.45±16.24ng/ml), and TNF-αlevel (23.18±4.27pg/ml) of women in the study group at 2 hours after surgery were all significant lower than those of women in the control group (P＜0.001), but there was no significant difference in postoperative sedation effect (Ramsay score) of women between the two groups. VAS scores of women in the study group at 4 and 12 hours after surgery were 2.4±1.1 points and 1.5±0.7 points, which were significant lower than those of women in the control group (P＜0.001). Conclusion: The effect of sufentanil for preventive analgesia during cesarean section is good, and the stress response of parturient is less, so it has good clinical application value.

2020 Vol. 28　(10):　1688-1690 [Abstract]（ 346 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

To compare the clinical effects of single balloon, double balloon, and dinoprostone suppositories for the uterine cervical maturation and induction of labor of pregnant women with full term pregnancy. Methods: A retrospective analysis was performed on 300 pregnant women with full term pregnancy who had accepted induction of labor from January 2018 to June 2019. According to the different methods of promoting cervical maturity, they were divided into 3 groups, which included 100 women experienced promoting cervical maturity by single balloon in group A, 100 women experienced promoting cervical maturity by double balloon in group B, and 100 women experienced promoting cervical maturity by dinoprostone suppositories in group C. The cervical Bishop scores, the time from induction to labor, total labor time, postpartum hemorrhage volume, and delivery methods of women were compared among the three groups. Results: There were no significant different in the effective rate of cervical ripening (92%, 89% vs. 91%) among the three groups (P>0.05). The cesarean section rate of women in group C (28%) was significant higher than that (9%) of women in group A and that (11%) of women in group B (P＜0.05). The value added of cervical Bishop score of women in group A was 4.0±1.4 points, which had no significant different from that (3.5±1.6 points) of women in group B and that (3.6±1.6 points) of women in group C (P>0.05). The time from drug used to delivery and the total duration of labor of women in group C were 13.9± 10.8h and 7.1±2.6h, which were significant shorter than those in group A and B (P＜0.05). There was no significant different in postpartum blood loss of women among group A (335±91ml), group B (358±100ml) and group C (348±89ml) (P>0.05). There was no significant difference in neonatal birth weight among group A (3476±331g), group B (3482±296g) and group C (3483±296g) (P>0.05). Conclusion: There is no significant difference in the effect of promoting cervical maturation of the three induction of labor methods. The time from induction of labor to labor and the total labor time by dinoprostone suppositories are shorter than those by single or double balloon, but the cesarean rate of women after dinoprostone suppositories used is higher. So it is safer to promote cervical maturity by single or double balloon if no different effect of induction of labor.

2020 Vol. 28　(10):　1695-1697 [Abstract]（ 317 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )

To explore the influence of post abortion care (PAC) service on the cognition and implement of contraception of women. Methods: 600 women who wanted artificial abortion were randomly divided into observation group and control group (300 cases in each group) from March 2017 to February 2018. The women in the control group had received routine nursing and health education after abortion, and the women in the observation group had received PAC service except routine nursing and health education after abortion. The awareness and knowledge of contraception of women in both groups were evaluated. The satisfaction degree and repeat abortion rate of women after abortion were recorded. Results: The rate of knowledge of contraception after abortion of women in the observation group (92.6%) was significant higher than that (54.3%) of women in the control group, and the rate of choosing highly effective contraception of women in the observation group was also significant higher (P＜0.05). The rate of repeated abortion at 6 months and 12 months after this abortion of women in the observation group were 2.3% and 5.3%, which were significant lower than those (5.7% and 10.3%) of women in the control group, but the satisfaction degree with providers of women in the observation group was 98.0%, which was significant higher than that (84.7%) of women in the control group (P＜0.05). Conclusion: PAC service can improve the awareness of contraceptive knowledge, promote the satisfaction with providers, improve the utilization rate of highly effective contraception after abortion, and reduce the rate of repeated abortion rate.

2020 Vol. 28　(10):　1702-1705 [Abstract]（ 350 ） HTML (0 KB)  PDF  (0 KB)  ( 34 )

With the widespread use of routine assisted reproductive technology (ART), such as artificial insemination, in vitro fertilization-embryo transfer, intracytoplasmic sperm injection, preimplantation genetic diagnosis or screening, and gamete transfer, the evaluation of the risks associated with ART becomes more and more important. Some long-term follow-up data show that, compared with natural pregnancy, an increasing number of maternal and offspring with adverse pregnancy outcomes may be related to ART, and the risk of birth defects is also increasing after ART treatment. This review is intended to provide a detailed overview of perinatal outcomes associated with routine ART of singleton pregnancy. With new ART is constantly being introduced, the health monitoring of offspring of pregnant women after ART treatment is vital importance.

2020 Vol. 28　(10):　1713-17118 [Abstract]（ 293 ） HTML (0 KB)  PDF  (0 KB)  ( 35 )