|
|
|
| Effect of intravenous anesthesia of etomidate combined with propofol on quality of anesthesia and inflammatory factors after laparoscopic hysterectomy |
| The Second Affiliated Hospital of Air Force Military Medical University, Yan 'an, Shaanxi Province, 710038 |
|
|
|
|
Abstract To investigate the effect of intravenous anesthesia of etomidate combined with propofol for treating women on their postoperative recovery quality and inflammatory factors，such as (interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) after laparoscopic hysterectomy. Methods: 114 women who wanted laparoscopic hysterectomy were enrolled and randomly divided into three groups from January 2017 to September 2019. 45 women in group A had received etomidate combined with propofol for intravenous anesthesia, 36 women in group B had received propofol for intravenous anesthesia, and 33 women in group C had received etomidate for intravenous anesthesia. The values of diastolic blood pressure, systolic blood pressure, heart rate, recovery time, extubation time, recovery room retention time, and levels of IL-6, CRP, and TNF-α, and adverse reaction rate of women were compared among the three groups. Results: At T1, the diastolic blood pressure, systolic blood pressure, and heart rate of women in group A were 80.21±9.92 mmHg, 139.64±8.62 mmHg, and 87.34±5.89 time/min, which were significant lower than those in group B and C (P＜0.05). At T2-T3, there were no significant different in the values of diastolic blood pressure, systolic blood pressure, and heart rate of women among the 3 groups (P>0.05). Wake time, extubation time, stay time in recovery room of women in group A were siginificant shorter than those of women in group B and C (P＜0.05). The serum levels of IL-6, CRP and TNF-α of women in the three groups at T3 were significant lower than those at T0, and those of women in group A were siginificant lower than those of women in group B and C (P＜0.05). The rate of adverse reaction of women in group A was 4.4%, which was significant lower than that (33.3%) of women in group B or that (15.2%) of women in Group C (P＜0.05). Conclusion: Intravenous anesthesia by etomidate combined with propofol for treating women during laparoscopic hysterectomy can improve postoperative quality of anesthesia awakening of women and can inhibition of inflammatory factor response effectively, and has better safety.
|
|
|
|
|
|
|
|
|
