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| Expression of SDF-1/CXCR4 of infertility women with endometriosis |
| The Third People's Hospital of Hangzhou, Zhejiang Province, 310009 |
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Abstract To investigate the expression and significance of chemokine receptors 4 (CXCR 4) and stromal cell derived factors-1of infertility women with endometriosis. Methods: From December 2016 to May 2019, 164 women with endometriosis were included and were divided into two groups according to whether complicated with infertility, and 50 women with uterine myoma who underwent surgical treatment during the same time were selected in control group. The levels of SDF-1, CXCR4, MMP-9, and VEGF of women were compared among the groups, and the relationship between the expression of the levels of SDF-1 and CXCR4 and endometriosis complicated with infertility was analyzed. Results: The levels of SDF-1, CXCR4, MMP-9, and VEGF of infertility women with endometriosis were significant higher than those of women in the control group (P＜0 05). Correlation analysis showed that the expression levels of SDF-1 and CXCR4 were positively correlated with the expression levels of MMP-9 and VEGF (r=0.683, 0.701, 0.695, 0.674). The levels of SDF-1, CXCR4, MMP-9, and VEGF of infertile women with endometriosis were significant higher than those of women without infertile. Conclusion: CXCR4 may be lead to the the occurrence of infertility process of women with endometriosis by involving in endometrial proliferation and invasion.
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