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| Expression of mRNA-26a-5p in plasma and placenta in pregnant women with preeclampsia and its correlation with the severity of preeclampsia |
| Daye People's Hospital, Hubei province, 435100 |
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Abstract To investigate the expression of microRNA-26a-5p (miR-26a-5p) in plasma and placenta of pregnant women with preeclampsia, and to study its correlation with the severity of preeclampsia. Methods: 122 pregnant women with preeclampsia were enrolled in study group, and 61 normal pregnant women were selected in control group. The values of systolic pressure (SP) and diastolic pressure (DP), the levels proteinuria, plasma albumin, and the expression of microRNA-26a-5p in plasma and placenta of women were measured and compared between the two groups. The expression of microRNA-26a-5p in plasma and placenta tissues was compared among women with different severity of preeclampsia. Pearson correlation was used to analyze the correlation between the expression of microRNA-26a-5p of pregnant women with preeclampsia and their clinicopathological characteristics. Results: The values of SP and DP, proteinuria level, and the miR-26a-5p level in plasma and placenta tissues of women in the observation group were significant higher than those of women in the control group, but the plasma albumin level of women in the study group was significant lower. The miR-26a-5p level in plasma and placenta tissues of women with severe preeclampsia was significant higher than that women with preeclampsia (all P＜0.05). The miR-26a-5p level in plasma and placenta of pregnant women with preeclampsia was positively correlated with their values of SP and DP, and their proteinuria level, but was negatively correlated with their plasma albumin level (P＜0.05). Conclusion: miR-26a-5p level in plasma and placental tissues of pregnant women with preeclampsia is high, and it is related to the severity of preeclampsia, which may be used as a new molecular target for diagnosing and treating preeclampsia.
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