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| Correlation of the levels of f-β-HCG, AFP,uE3，and Hcy and gestational hypertension during the second trimester of pregnancy |
| Mianyang People's Hospital, Sichuan Province, 621000 |
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Abstract To analyze the values of free human chorionic gonadotrophin subunit (f-β-HCG), alpha fetoprotein (AFP), uncon jugated estriol (uE3), and homocysteine (Hcy) for predicting gestational hypertension of women during the second trimester of pregnancy. Methods: The paper adopts retrospective analysis of the pregnant women from January 2019 to December 2019. 140 women with gestational hypertension were in study group and 300 women with head delivery were selected in control group. The levels of f-β-HCG, uE3, AFP, and Hcy of these women during the second trimester of pregnancy were compared between the two groups. Then the curve area under the ROC curve (AUC) and the Youden index were used to estimate the predictive value of serological index for gestational hypertension. Results: Serum f-β-HCG and Hcy levels of women in the study group were significant higher than those of women in the control group, but the levels of uE3 and AFP of women in the study group were significant lower (P＜0.05). The AUC value of serum f-β-HCG level, AFP level, uE3 level or Hcy level for predicting gestational hypertension was 0.651, 0.325, 0.377 or 0.868, the specificity was 80%,0%, 1% or 82%, and the sensitivity was 52%, 100%, 100%, or 82%. The AUC value of combined serum f-β-HCG level, AFP level, uE3 level and Hcy level for predicting gestational hypertension was 0.931, the specificity was 87%, and the sensitivity was 90%. Conclusion: The serum f-β-HCG and Hcy levels of the women with gestational hypertension have increased significantly, while the levels of AFP and uE3 have decreased significantly, which could be used as a serological marker for predicting gestational hypertension.
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