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| The relationship between subchorionic hematoma of women during the first trimester of pregnancy and their NK cells and surface molecule (CD49d and CD11b) of NK cells after IVF-ET |
| Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu Province, 213000 |
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Abstract To investigate the relationship between subchorionic hematoma (SCH) of women during the first trimester of pregnancy and their NK cells (CD56+CD16+NK and CD56+16-NK) and surface molecule (CD49d and CD11b) of NK cells after IVF-ET. Methods: 41 women during the first trimester of pregnancy after IVF-ET were selected and were divided into 20 women with chorionic hematoma in observation group and 21 women without chorionic hematoma in control group from February 2019 to December 2019. The expression levels of CD56+CD16+NK cells and CD56+CD16-NK cells, and their surface integrin molecules CD49d and CD11b expressions in peripheral blood of women were compared between the two groups. The proportions of CD56+CD16+NK cells in peripheral blood lymphocytes of women in the observation group and the control group were 9.73 (6.32-15.18)% and 9.96 (6.50-12.68)%, respectively, and the proportions of CD56+CD16-NK cells in peripheral blood lymphocytes of women in the observation group and the control group were 4.61 (3.54-8.39)% and 5.71 (4.35-8.86)%, respectively, which had no significant difference between the two groups (P>0.05). The proportion of CD11b on the surface of CD56+CD16+NK cells of women in the observation group and the control group were 98.59 (97.20-99.33)% and 100.00 (99.80-100.00) %, respectively. The proportion of CD11b on the surface of CD56+CD16-NK cells of women in the observation group and the control group were 78.09 (60.64-86.24)% and 87.09 (80.36-91.33)%, respectively, which of women in the observation group were significant lower than those of women in the control group (all P＜0.05). CD49d on the surface of CD56+CD16+NK cells of women in the observation group and the control group were 100.00 (99.97-100.00)% and 100.00 (100.00-100.00)%, respectively, and CD49d on the surface of CD56+CD16-NK cells of women in the observation group and the control group were 100.00 (99.97-100.00) % and 100.00 (100.00-100.00) %, respectively, which of women had no significant diffrent between the two groups (P>0.05). Conclusion: The expression of CD11b on the surface of CD56+CD16+NK cells and CD56+CD16-NK cells in the peripheral blood of women with SCH during the first trimester of pregnancy after IVF-ET is lower than that of women without SCH, but there is no difference in CD49d expression on the surface of the two cell subtypes.
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