Abstract To explore the value of the levels of serum monocyte chemoattractant protein-1 (MCP-1), omentin, and endostatin (ES) level for diagnosing polycystic ovary syndrome (PCOS). Methods: 96 women with PCOS were selected in group A, 68 women with Cushing syndrome were selected in group B, and 36 healthy volunteers were selected in group C from March 2018 to March 2019. The serum levels of MCP-1, omentin, and ES of women were compared among the three groups. The value of the serum MCP-1 level, omentin level, or ES level only, and the value of combined the serum MCP-1 level, omentin level, and ES level for diagnosing PCOS were analyzed. The ROC curve was used to analyze the evaluation efficiency. Results: The serum levels of MCP-1 and omentin of women in group A were significant lower than those of women in group B and C, but the serum ES level of women in group A were significant higher (P＜0.05). The serum levels of MCP-1 and omentin of women in group B were significant lower than those of women in group C, but the serum level of ES of women in group B were significant higher (P＜0.05). The sensitivity of combined McP-1 level, omentin level, and ES level for diagnosing PCOS was significant lower than that of McP1 level, omentin level, or ES level only, but the specificity of the combined of McP-1 level, omentin level, and ES level for diagnosing PCOS was significant higher (P＜0.05). The area under ROC curve of McP-1 level, omentin level, or ES level only for diagnosing PCOS was 0.902, and that of the combined of McP1 level, omentin level, and ES level for diagnosing PCOS was 0.889 (P>0.05). Conclusion: The combined of McP-1 level, omentin level, and ES level for diagnosing PCOS can improve the sensitivity, the specificity, and the accuracy effectively.
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