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Abstract With the widespread use of routine assisted reproductive technology (ART), such as artificial insemination, in vitro fertilization-embryo transfer, intracytoplasmic sperm injection, preimplantation genetic diagnosis or screening, and gamete transfer, the evaluation of the risks associated with ART becomes more and more important. Some long-term follow-up data show that, compared with natural pregnancy, an increasing number of maternal and offspring with adverse pregnancy outcomes may be related to ART, and the risk of birth defects is also increasing after ART treatment. This review is intended to provide a detailed overview of perinatal outcomes associated with routine ART of singleton pregnancy. With new ART is constantly being introduced, the health monitoring of offspring of pregnant women after ART treatment is vital importance.
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