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Abstract To investigate the correlation between serum anti-Miller hormone (AMH) level and early spontaneous abortion after in vitro fertilization (IVF). Methods: During July 2016 to June 2018, 242 women with intrauterine single pregnancy after IVF were included and were divided 38 women with early spontaneous abortion in study group and 204 women with live birth in control group. Serum AMH levels were measured. The predictive value of AMH level for early spontaneous abortion was analyzed by Receiver operating characteristic curve (ROC). Multivariate logistic regression was used to analyze the relationship between serum AMH level and pregnancy outcomes of women after IVF. Results: There were no significant different in BMI value, infertility years, abortion history, basal levels of LH and E2, and IVF related factors, such as Gn dosage, days of Gn used and endometrium thickness on HCG day between the two groups (P>0.05), but there were significant different in age, proportion of primary infertility, basic FSH level, and AMH level between the two groups (P＜0.05). ROC curve analysis indicated that serum AMH level had certain predictive value for predicting early spontaneous abortion of women after IVF. The optimal threshold of serum AMH level for predicting early spontaneous abortion was 3.14 ng/ml, and its area under the AUC curve was 0.753 (95% CI: 0.693-0.806), its sensitivity was 44.7%, and its specificity was 94.6%. Multivariate logistic regression model found that primary infertility, low levels of basal FSH and AMH were the risk factors of spontaneous abortion of women after IVF. Conclusion: AMH level of women after IVF is related to their early spontaneous abortion, which can be used as one of the reference indicators of the risk of women with early spontaneous abortion.
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