|
|
|
| Expression characteristics and clinical significance of Tim-3 and PD-1 in peripheral blood mononuclear cells of women with unexplained recurrent abortion or threatened abortion |
| 1. The Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan, Shandong Province, 250011；2. PLA 960th Hospital |
|
|
|
|
Abstract To investigate the expression characteristics and clinical significance of T-cell immunoglobulin-3 (Tim-3) and programmed death factor-1 (PD-1) in peripheral blood monocytes of women with unexplained recurrent abortion (URSA) or threatened abortion. Methods: 80 women with URSA were selected in group A, women with threatened abortion during the first trimester of pregnancy were selected in group B, and 80 normal pregnant women during the first trimester of pregnancy were selected in group C. Peripheral blood of these women in the three groups were collected and the mononuclear cells were isolated. The expression levels of Tim-3 and PD-1 in monocytes of women were detected, and serum IL-4, IL-12, IFN-γlevels of these women were measured. Results: The Tim-3 level, PD-1 level, or IL-4 level of women in group A was the lowest, and which of women in group C was the highest. The IL-12 level or IFN-γlevel of women in group A was the highest, and which of women in group C was the lowest (all P＜0.05). Correlation analysis showed that IL-12 level was negatively correlated with IL-4 level, Tim-3 level, or PD-1 level, but was positively correlated with IFN-γlevel (all P＜0.05). IL-4 level was positively correlated with IFN-γlevel, Tim-3 level, or PD-1 level, but IFN-γlevel was negatively correlated with Tim-3 level or PD-1 level (all P＜0.05). Tim-3 level was positively correlated with PD-1 level (P＜0.05). Conclusion: The occurrence of URSA and threatened abortion may be related to the decrease of the expression levels of Tim-3 and PD-1 of monocytes in peripheral blood of women, which can be used as a potential target spot for treating URSA and threatened abortion.
|
|
|
|
|
|
|
|
|
