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Abstract To investigate the effect of gonadotropin-releasing hormone α (GnRH-α) and gestrinone for treating women with ovarian endometriosis cysts after ovarian cystectomy, and to study their influence on the levels of serum hormone, assisted T(Th) cytokines, anti-Mullerian hormones (AMH), and the effect of tumor marker CA125. Methods: 90 women who had experienced ovarian endometriosis cystectomy were selected and were divided into observation group and control group (45 cases in each group) according to the random number table method from January 2016 to January 2018. Then the women in the observation group were given GnRH-α, and the women in the control group were given gestrinone. The clinical efficacy of the women in the two groups was analyzed. The levels of serum follicle stimulating hormone (FSH), estradiol (E2), FSH/Luteinizing Hormone (LH), Th cytokine, AMH, and CA125 of the women in the two groups were compared before and after treatment. And the recurrence rate and pregnancy rate of women in the two groups were followed up for 1 year. Results: The total effective rate of women in the observation group was 97.8%, which was significant higher than that (80.0%) of women in the control group. After treatment, the levels of serum FSH, E2, FSH/LH, and CA125 of women in the two groups had decreased significantly, while the level of AMH had increased significantly, and which’s changes of women in the observation group was significant more than those of women in the control group (P＜0.05). The levels of interleukin-2 (IL-2) and interferonγ(IFN-γ) of women in the observation group were significant higher than those of women in the control group, but the levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) of women in the observation group were significant lower. The recurrence rate of women in the observation group was 6.78%, which was significant lower than that (20.0%) of women in the control group. The pregnancy rate of women in the observation group was 60.0%, which was significant higher than that (40.0%) of women in the control group (all P＜0.05). Conclusion: The therapeutic effect of GnRH-a for adjuvant treating women after ovarian endometriosis cystectomy is better than that of gestrinone treatment, which can significantly improve the levels of sex hormones, AMH and CA125, can restore the balance of Th cell factor, can reduce the recurrence rate, and can increase the pregnancy rate.
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