Objective: To study the relationship between intrauterine device (IUD) use and secondary infertility of women. Methods：IUD cohort and condom cohort were established according to contraceptives used by women after the first child delivery based on the National Free Prenatal Health Examination Project. The women of secondary infertility in the two groups were followed up. The influencing factors of secondary infertility were analyzed. Results：The infertility rate of women in IUD group and condom group was 18.7% and 18.1%, respectively. The infertility rates of women with IUD usage less than 1 year, 1-years, and ≥5 years were 18.6%, 19.8% and 16.9%, respectively. The infertility rates of women with IUD termination for non-medical reasons and medical reasons were 19.6% and 25.0%, respectively. No statistical correlation was found between IUD usage time or termination reason with the occurrence of secondary infertility. Multivariate logistic regression analysis showed that rate of secondary infertility of women in IUD group was 0.95 times of that of women in condom group (P>0.05). It was also found that male overweight and women in south area of Jiangsu province were the protective factors for infertility (P<0.05), but female age, female obesity, female anemia, and illness of the first child were the risk factors for infertility (P<0.05). Conclusion：IUD usage doesn’t increase the risk of secondary infertility.

2020 Vol. 28　(1):　13- [Abstract]（ 403 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To investigate the clinical efficacy of levonorgestrel release intrauterine system (LNG-IUS) combined with gonadotropin-releasing hormone analogue (GnRH-a) for adjuvant therapy of women with severe endometriosis (EMT) after operation, and to anlyze its influence on sex hormone levels of women. Methods: 100 women with severe EMT who had undergone surgery from January to December 2018 were randomly divided into observation group and control group. 50 women in the control group were treated by GnRH-a only, and 50 women in the observation group were treated by LNG-IUS combined with GnRH-a. The clinical efficacy, sex hormone levels, and ovarian reserve function of women before surgery (T0), postoperative 6 months (T1), 12 months (T2) were compared betweent the two groups. Result: The dysmenorrheal degree, sexual pain score, and the serum CA125 level of women in the two groups at T1 and T2 had significantly decreased after operation (P<0.05). The dysmenorrhea score of women in the observation group at T2 was 1.66±1.09 point, which was significant lower than that (2.06±1.33 points) of women in the observation group at T1 and that (2.04±1.23 points) of women in the control group at T2. The serum CA125 level of women in the observation group at T2 was 9.82±1.84 mg/L, which was significant lower than that(12.42±2.62 mg/L) of women in the observation group at T1 (P<0.05). The levels of FSH, LH and E2 of women in both groups had significantly decreased after operation, and the serum E2 level of women in the observation group at T2 was significant higher than that of women in the control group (P<0.05).The number of ovarian sinus follicle and PSV of women in both groups had significantly decreased after operation, and that of women at T2 were significant higher compared to that at T1 (P<0.05), but there was no significant different in the number of ovarian sinus follicle and PSV of women between the two groups (P>0.05). Conclusion: LNGIUS combined with GnRH-a for adjuvant therapy of women with severe EMT can increase clinical efficacy, improve sex hormone levels, and has no adverse effect on ovarian reserve function recovery.

2020 Vol. 28　(1):　22- [Abstract]（ 379 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

Objective: To explore the clinical efficacy of ditroxyprogesterone tablets combined with choriotropin for treating women with unexplained recurrent abortion (URSA), and to study its influence on T lymphocyte cell and inflammatory factor levels of women. Methods: 100 women with URSA were enrolled in this study and divided into group A and Group B (50 cases in each group) according to simple randomized method from June 2017 to November 2018. The women in group A were treated with ditroxyprogesterone tablets combined with chorionic gonadotropin, and the women in Group B were treated with luteinone combined with chorionic gonadotropin. The serum levels of (IL)-4, IL-6, IL-10, IL-17, INF- γ, TNF-α, highly sensitive C-reactive protein (hs-CRP), CD4 regulatory T cell Treg (Treg/CD4, CD4 T helper cell Th17 (Th17/CD4), helper T cell 17 / regulatory T cell (Th17/ Treg) of women during 8 and 12 gestational weeks were compared between the two groups. The pregnancy outcomes of women in the two groups were counted. Results: The levels of IL-4,IL-10,Treg CD4 of women in both groups during 12 gestational weeks were significant higher than those of women during 8 gestational weeks, but the levels of IL-6,IL-17,INF- γ, TNF- α, hs-CRP,Th17/CD4, and Th17/ Treg of women in the two groups during 12 gestational weeks were significant lower than those of women during 8 gestational weeks, and the change degree of those of women in group A was significant more than those of women in group B (P<0.05). The rate of abortion of women in group A was 17.0%, which was significant lower than that (40.9%) of women in group B,and the rate of full term delivery of women in group A 63.8%, which was significant lower than that (31.8%) of women in group B (P<0.05). Conclusion: The combination of ditroxyprogesterone tablets and choriotropin for treating women with URSA is effective, which can regulate the level of T lymphocyte factor and inflammatory factor, can reduce the risk of abortion, and can mprove the success rate of pregnancy preservation by promoting the balance of mother-fetus immunity.

2020 Vol. 28　(1):　32- [Abstract]（ 342 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To investigate the influence of cyclosporine A (CsA) combined with lymphocyte immunization of T cell (LIT) fro treating women with unexplained recurrent spontaneous abortion (URSA) on their serum T cell subsets, anticardiolipin antibody (ACA) level, and pregnancy outcomes. Methods: 100 pregnant women with URSA were enrolled and were devided into study group and control group (50 cases in each group). The women in the study group were treated by CSA combined with LIT, and the women in the control group were treated by LIT. The levels of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and ACA antibodies (ACA-IgM, ACA-IgG) of all women were observed before and after treatment, and the pregnancy outcomes of women was compared between the two groups. Results: Ather treatment, Values of CD3+, CD4+, and CD4+/CD8+ of women in the study group had increased significantly, but CD8+ value and levels of ACA-IgM and ACA-IgG of women in the study group had decreased significantly, and the change degree of women in the study group were significant more than that of women in the control group (P<0.05). The successful delivery rate of women in the study group was 92.0%, which was significant higher than that (72.0%) of the control group (P<0.05). The incidences of abortion and pregnancy-induced hypertension of women in the study group were 4.0% and 2.0%, which were significant lower than those (18.0% and 16.0%) of women in the control group (P<0.05). Conclusion: CsA combined with LIT used for treating women with URSA can significantly reduce ACA antibody levels, improve immune function, reduce abortion rate, and improve pregnancy outcome, which’s effect is better than LIT used alone.

2020 Vol. 28　(1):　40- [Abstract]（ 286 ） HTML (0 KB)  PDF  (0 KB)  ( 38 )

Objective: To explore the association between elevated thyroid stimulating hormone (TSH) level and body mass index (BMI) of reproductive age women in Shenzhen. Methods: A total of 256 675 reproductive age women who had participated in the National Pre-pregnancy Health Examination Program in Shenzhen from January 2013 to December 2018 were selected as the research objects. The relevant information about physical examination and laboratory examination of these research objects were collected by questionnaire. The multivariate logistic regression model was used to analyze the association between BMI and elevated TSH level of reproductive age women. Results: In these 256 675 reproductive age women, the women with elevated TSH level accounted for 3.39%, the women with underweight(BMI <18.5kg/m2) accounted for 20.03%, and the women with overweight/obese (BMI≥24.0kg/m2) accounted for 11.99%. The multivariate analysis showed that compared with those of women with normal TSH level, the risk of overweight/obese of women with elevated TSH level had increased by 29% (OR=1.29, 95%CI: 1.20-1.38), and the risk of underweight of women with elevated TSH level had decreased by 13% (OR=0.87, 95%CI: 0.82-0.93). Conclusion: Elevated TSH level of reproductive age women was positively associated with BMI increased, so keeping TSH level in an appropriate range might reduce the risk of overweight/obese of reproductive age women.

2020 Vol. 28　(1):　48- [Abstract]（ 374 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore the effect of disease of pregnant women with gestational diabetes mellitus (GDM) and subclinical hypothyroidism on their bone mineral density, and levels of osteocalcin (OC) and 25-hydroxyvitamin D3 (25-OH-VD3). Methods: 120 pregnant women with GDM and subclinical hypothyroidism were selected in experimental group, and 120 healthy pregnant women were selected in control group during the same period. The bone mineral density, and levels of OC and 25-OH-VD3 of all women were detected. And maternal and infant pregnancy outcomes of all women were observed. Results: The rate of normal bone mineral density of women in the experimental group was 72.5%, which was significant lower than that (85.0%) of women in the control group. The incidence of bone mineral density decreased and OC level of women in the experimental group were 20.0% and 9.86±0.13μg/L, which were significant higher than those (5.0% and 7.21±0.15μg/L) of women in the control group. The level of 25-OH-VD and calcaneus BMD value of women in the experimental group were 16.09±5.34μg/L and 0.91±0.18 g/cm, which were significant lower than those (18.96±6.36μg/L and 1.14±0.21 g/cm2) of women in the control group (P<0.05). The incidence of low birth weight and neonatal asphyxia in the experimental group were 20.0% and 10.0%, which were significant lower than those (5.0% and 1.7%) in the control group (P<0.05). Conclusion: The diseases of pregnant women with GDM and subclinical hypothyroidism can reduce the expression levels of bone mineral density, and levels of osteocalcin and 25-hydroxyvitamin D, which can increase the risk of neonatal asphyxia and low body weight, so it is should be paid attention to in clinical practice.

2020 Vol. 28　(1):　56- [Abstract]（ 319 ） HTML (0 KB)  PDF  (0 KB)  ( 44 )

Objective: To investigate the effect of laparoscopic myomectomy on angiogenesis, stress response, and immune function of patients with hysteromyoma. Methods: 90 patients with hysteromyoma were randomly divided into conventional group and observation group (45 cases in each group). The patients in the conventional group had undergone open surgery for myomectomy, and the patients in the observation group had undergone laparoscopic myomectomy. The changes of angiogenesis, stress response, and immune function of all patients were compared before and after surgery. Results: On the 1st and 3rd day after operation, the levels of EGF, VEGF, VEGFR2, ALD, AngⅡ, NE, CD3+, and CD8+ of patients in the two groups had increased significantly, but the levels of CD3+, CD4+, and CD4+/CD8+ of patients had decreased significantly (P>0.05). On the 1st day after operation, the levels of EGF, VEGF, VEGFR2, ALD, AngII, NE, and CD8+ of patients in the observation group were 2.85±0.82μg/L, 159.79±16.98pg/ml, 3764.82±380.32pg/mL, and 35.66±4.62%, respectively, which were significant lower than those of women in conventional group (P>0.05). On the 3rd day after operation, the levels of EGF, VEGF, VEGFR2, ALD, AngII, NE, and CD8+ of patients in the observation group were 2.08±0.49μg/L,130.63±15.73pg/ml, 3320.61±352.36pg/ml, and 30.37±3.62%, respectively, which were significant lower than those of women in conventional group (P>0.05). On the 1st day after operation, the levels of CD3+, CD4+, and CD4+/CD8+ of patients in the observation group were 44.75±6.27%, 29.18±3.71%, and 1.26±0.13 respectively, which were significant lower than those of women in conventional group (P>0.05). On the 3rd day after operation, the levels of CD3+, CD4+, and CD4+/CD8+ of patients in the observation group were 56.65±8.22%, 35.35±6.21%, and 1.38±0.15, respectively, which were significant lower than those of women in conventional group (P>0.05). Conclusion: Compared with those of patients who experinced traditional open surgery for myomectomy, laparoscopic myomectomy can reduce the stress response and immunosuppression of patients, and their angiogenesis related indicators of patients has less fluctuation with better overall curative effect.

2020 Vol. 28　(1):　64- [Abstract]（ 324 ） HTML (0 KB)  PDF  (0 KB)  ( 37 )

Objective: To explore the effect of high-performance antiretroviral therapy (HARRT) used from 14 gestational weeks for blocking maternal human immunodeficiency virus (HIV) infected infant. Methods: 60 HIV-infected pregnant women were selectedin this study from February 2014 to August 2017. Among them, 30 women in observation group were treated with HARRT from 14 gestational weeks, and 30 women in control group were treated with HARRT from 28 gestational weeks. The number of CD4+T lymphocyte and HIV viral load of women before treatment (T0), 1 month before delivery (T1), and 3 months after delivery (T2) were compared between the two groups. The delivery status and clinical curative effect of HIV blockade between mother and infant were also compared between the two groups. Results: There was significant different in the number of CD4+T lymphocyte of women at T0, T1 and T2 between the two groups, and   the women with the number of CD4+T lymphocyte increased over 30% at T1 or T2 in the observation group was significant more than that in the control group (P<0.05). There were no significant difference in the number of women with HIV viral load less than 50 copies/ml at T1 and T2, and rates cesarean section, premature delivery, low birth weight infants, and neonatal mild asphyxia between the two groups (P>0.05). Conclusion: HARRT used for maternal and infant blockade of HIV infected from 14 gestational weeks can promote the immune function reconstruction of pregnant women with HIV infected, and can increase the rate of maternal and infant blockade, which dosen’t increase the adverse pregnantcy outcomes. So it is suggested that HARRT shoule be clinical used as soon as possible.

2020 Vol. 28　(1):　72- [Abstract]（ 320 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To explore the relationship between cytotoxic T lymphocyte associated antigen-4 (CTLA4) of women and their risk of unexplained habitual abortion (UHA) occurance. Methods: 98 women with UHA were selected in study group, and another 107 normal pregnant women were selected in control group. Serum of the women in the two groups was collected and their DNA from cell blood was extracted. Polymerase chain reaction-restriction fragment polymorphism (PCR-RFLP) was used to detect the genotypes of CTLA-4 gene rs5742909 loci, rs4553808 loci and rs231775 loci. The expressions of serum Th1 and Th2 cytokines levels were detected by ELISA. The relationship between CTLA4 genotype and the risk of UHA, and the relationship between genotypes and inflammatory factor level were analyzed. Results: The levels of serum interferon-γ (IFN-γ), tumor necrosis factor-ɑ (TNF-ɑ), and interleukin-2 (IL-2) of women in the study group were significant higher than those of women in the control group, while the levels of IL-4, IL-6, and IL-10 of women in the study group were significant lower (P<0.05). The frequency value of actual gene rs5742909 loci and rs231775 loci of CTLA4 gene of women in the study group had no significant different from their theoretical frequency value (P>0.05), which conformed to Hardy-Weinberg's law of genetic balance. The T allele frequency of s5742909 loci and the G allele frequency of rs231775 loci of women in the study group were significant higher than those of women in the control group (P<0.05). The levels of serum IFN-γ, TNF-ɑ, IL-2, IL-4, IL-6, and IL-10 of women with rs5742909 and rs231775 genotypes had significant different (P<0.05). Logistic multivariate regression analysis showed that the relative risk of women carried rs5742909 T allele was 1.984 times higher than that of UHA women carried C allele, and the relative risk of women carried rs231775 T allele was 1.837 times higher than that of UHA women carried C allele. Conclusion: The polymorphisms of rs5742909 and rs231775 loci of CTLA4 gene are associated with UHA occurance, and C→T mutation at rs5742909 loci and A→G mutation at rs231775 loci can increase the risk of UHA occurance.

2020 Vol. 28　(1):　80- [Abstract]（ 373 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

Objective: To investigate the clinical outcomes and complications of different surgical procedure for treating women with cesarean scar pregnancy (CSP). Methods: The data of 102 women with CSP from August 30, 2016 to August 30, 2018 were analyzed retrospectively, which included 40 women in group A were treated by uterine artery embolization combined with hysteroscopy lesion resection, 32 women in group B were treated by hysteroscopy lesion resection, and 30 women in group C were treated by laparoscopy lesion resection. The level of surgical related indexes and postoperative complications situation of women in the three groups were analyzed, and the pregnancy outcomes of all women were followed up until May 30, 2019. Results: The diameter of blastocysts of women in group B was significant smaller than that of women in group A or group C. The women in group C had mainly type III CSP, the women in group B had mainly type I CSP, and the women in group A had mainly type II CSP. The operation time,  intraoperative blood loss, and total complication rate of women in group C were significant more than those of women in group A and group B (P<0.05). There were no significant different in the duration of postoperative continuous bleeding, the rate of conversion to open surgery, incidence of uterine perforation, the rate of profuse bleeding, and rate of postoperative infection of women among the 3 groups (P>0.05). A total of 60 women had fertility requirements after surgery (22 women in group A, 20 women in group B, and 18 women in group C). The median followup time was 19 months. The natural pregnancy rate of these 60 women was 65.0%, and that of women in group A, B, and C were 15/22, 14/20, and 10/18, respectively, which had no significant difference among the three groups (P>0.05). The incidence of CSP again of all women were 17.9% (7/39), and the incidence of CSP again of women in group A, B, and C were 3/15, 3/14, and 1/10, respectively, which had no significant difference among the three groups (P>0.05). The success rate of delivery of women in group A, B, and C were 9/15, 9/14, and 7/10, respectively, which had no significant difference among the three groups (P>0.05). There was no significant difference in serious adverse perinatal outcomes among the 3 groups. Conclusion: Uterine artery embolization combined with hysteroscopy lesion resection, hysteroscopy lesion resection, and laparoscopy lesion resection for treating women with cesarean scar pregnancy all have high rates of natural pregnancy and success delivery, and also have less adverse perinatal outcomes. Laparoscopy lesion resection for treating women with type III CSP has a higher incidence of complication.

2020 Vol. 28　(1):　89- [Abstract]（ 329 ） HTML (0 KB)  PDF  (0 KB)  ( 36 )

Objective: To investigate the effect of progesterone combined with modified shoutai pill for treating pregnant women with early threatened abortion (TA) because of kidney deficiency, and to study its influence on inflammatory factors. Methods: The clinical data of 98 women with TA from January 2015 to August 2018 were retrospective analyzed. Among them, 54 women in the study group were treated by progesterone and HCG combined with modified shoutai pill, and 44 women in the control group were treated by progesterone and HCG. The TCM syndrome scores, levels of sex hormones and inflammatory cytokines, and pregnancy outcomes of women were compared between the two groups. Results: After treatment, the TCM syndrome scores of all women in the two groups had significantly decreased, and the scores of vaginal bleeding (0.29±0.21 points), bleeding color (0.21±0.27points), lumbar and knee tenderness (0.22±0.27points), and swelling and lower abdominal pain scores (0.26±0.22 points), and bleeding time (0.20±0.15) of women in the study group were all signifficent lower than those of women in the control group (P<0.05). The levels of E2,β-hCG , and P of all women in the two groups had significantly increased  after treatment, and the levels of E2 (1087.26±253.23 pg/ml), β-hCG(102633.32±6723.72mIU/ml), and P (80.93±8.24pg/ml) of women in the study group were all signifficent higher than those of women in the control group (P<0.05). After treatment, the levels of IL-2 (3.45±0.15ng/ml), IL-4 (0.25±0.05ng/ml), and INF-r (1.13±0.11ng/ml) of women in the study group were signifficent better than those of women in the control group (P<0.05). The success rate of spuc treatment of women in the study group was 94.4%, which was significant higher than that (84.1%) of women in the control group (P<0.05), and the incidence of preterm labor of women in the study group was 0.0%, which was significant lower than that (13.5%) of women in the control group (P<0.05). Conclusion: Modified shoutai pill combined with progesterone and HCG for treating pregnant women with early threatened abortion can achieve good spuc treatment efficacy by alleviating clinical symptoms, promoting sex hormone level, and correcting the pathological shift of inflammatory factors of women.

2020 Vol. 28　(1):　98- [Abstract]（ 361 ） HTML (0 KB)  PDF  (0 KB)  ( 40 )

Objective: To investigate the value of hysteroscopy combined with transvaginal ultrasound examination for diagnosing endometrial polyps of postmenopausal women. Methods: From June 2017 to March 2019, 673 postmenopausal women who underwent hysteroscopy because of abnormal uterine bleeding or endometrial thickening indicated by transvaginal ultrasound were included this study. The average age of these included women was 61.3±9.3 years old, and their average durational of menopause was 10.7±2.7 years. The efficacy of transvaginal ultrasound examination combined with hysteroscopy for diagnosing endometrial polyps was calculated based on the final pathological results as diagnosis gold standard. Results: 256 women with endometrial polyps were diagnosed by transvaginal ultrasound, 377 women with missed diagnosis, and 11 women were misdiagnosed. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and Yoden index of diagnosis by transvaginal ultrasound were 40.4%, 72.5%, 1.47, 0.82, and 0.13, respectively. 550 women with endometrial polyps were diagnosed by hysteroscopy combined with transvaginal ultrasound examination, 83 women with missed diagnosis, and 4 women were misdiagnosed. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and Yoden index of diagnosis by hysteroscopy combined with transvaginal ultrasound were 86.9%, 90.0%, 8.69, 0.15, and 0.77, respectively. Hysteroscopy combined with transvaginal ultrasound examination had increased the sensitivity, specificity, positive likelihood ratio, and yoden index, while had decreased negative likelihood ratio. Conclusion: Vaginal ultrasound examination combined with hysteroscopy for diagnosing endometrial polyps of postmenopausal women has more accurate and lower of missed diagnosis rate.

2020 Vol. 28　(1):　106- [Abstract]（ 315 ） HTML (0 KB)  PDF  (0 KB)  ( 31 )

Objective: To investigate the influence of length of anesthesia on the incidence of infection and stress indicators of women after cesarean section. Methods: The clinical data of 1,200 women who exprienced cesarean section from January 30, 2016 to April 30, 2019 were analyzed retrospectively. The incidence of postoperative infection, the characteristics of postoperative infection, and the distribution of pathogens of all included women were observed. The influence of anesthesia time on the incidence of infection, and the changes of levels of norepinephrine, cortisol and blood glucose of women were also analyzed. Results: There were 70 (5.8%) women with postoperative infection, wich included 44.3% women with incision infections and 22.9%women with urinary system infections. The postoperative infection caused by gram-positive bacteria (mainly staphylococcus aureus) accounted for 55.6%, and the postoperative infection caused by gram-positive bacteria (mainly escherichia coli) accounted for 44.4%. The postoperative infection rate of women with maternal hemorrhage ≥200ml, intraoperative blood transfusion, anesthesia time ≥1h, no antibiotics used before operation, invasive examination ≥5 times, or with premature rupture of membranes had increased significantly (P<0.05). Multivariate analysis showed that intraoperative bleeding ≥200ml, anesthesia time ≥1h, and invasive examination ≥5 times were risk factors for postoperative infection, and prophylactic antibiotics used before cesarean section were protective factors (P<0.05). The levels of norepinephrine, cortisol and blood glucose of women with anesthesia time ≥1h were significant higher than those of women with anesthesia time <1h (P<0.05). Conclusion: The anesthesia time during cesarean section over 1h can increase the stress level and infection incidence of women after cesarean section, so shortening anesthesia time and prophylactic antibiotics used before cesarean section can reduce the postoperative infection occurance effectivly.

2020 Vol. 28　(1):　113- [Abstract]（ 282 ） HTML (0 KB)  PDF  (0 KB)  ( 44 )

Objective: To investigate the characteristics of vaginal secretion interleukin-8 (IL-8) level of pregnant women with genital tract infection by no streptococcus lactis, and its relationship with pregnancy outcomes. Methods: 105 pregnant women with genital infection by tract no streptococcus lactis were selected in study group, which included 62 women with premature rupture and 43 women without premature rupture of membrane, and included 36 women with IL-8 level <800ng/L and 69 women with IL-8 level ≥800 ng/L. And other 100 normal pregnant women were selected in control group. The vaginal secretion IL-8 levels of all included women were detected and followed up to delivery. The adverse pregnancy outcomes of all women were counted. Results: The IL-8 level of women in study group was 1032.62±402.35 ng/L, which was significant higher than that（35.51±52.69 ng/L）of women in the control group (P<0.05). In study group, the level of IL-8 of women with premature rupture of membrane was 1235.62±529.37 ng/L, which was significant higher than that（739.92±319.07 ng/L）of women without premature rupture of membrane (P<0.05). The incidences of intrauterine growth retardation, puerperal infection of women and neonatal infection in the study group was significant higher than those in the control group (P<0.05). In study group, the neonatal infection rate of women with without premature rupture of membrane was significant higher than that of women without premature rupture of membrane (P<0.05). The neonatal infection rate of women with IL-8 level ≥800 ng/L was 24.2%, which was significant higher than that（5.6%）of women with IL-8 level ≥800 ng/L (P<0.05). Conclusion: The level of IL-8 in vaginal secretions of pregnant women with genital tract no streptococcus lactis infection is significantly increased during the third trimester pregnancy, and the vaginal secretion level of IL-8 is closely related to premature rupture of membranes and neonatal infection. Detection of vaginal secretions IL-8 level of preganant women can help predict the genital tract infection by no streptococcus lactis and help prevent abnormal pregnancy outcomes.

2020 Vol. 28　(1):　120- [Abstract]（ 349 ） HTML (0 KB)  PDF  (0 KB)  ( 43 )

Objective: To explore the the effect of laser vaporization for treating endometrial polyps of patients, and to study its influence on endometrial thickness. Methods: 80 patients with endometrial polyp were selected as research objects, and were divided into stugy group and control group (40 cases in each group) by random number table from January 2017 to June 2018 8. The patients in the control group were treated with endometrial polyp electrotomy, and the patients in the observation group were treated with 2 micron laser vaporization excision. All patients were followed up for 9 months after operation. The situations of operation and menstrual recovery, endometrial thickness, rates of endometrial polyp recurrence, pregnancy, and complications of patients were compared between the two groups. Results: There was no signifficant difference in operation time of patients between the two groups (P>0.05). The bleeding volume during operation, hospitalization time, duration of menstrual cycle, menstrual volume, rates of endometrial polyp recurrence and complications of patients in the observation group were significant less than those of patients in the control group, but the endometrial thickness, the rate of pregnancy, and the cost of hospitalization of patients in the observation group were significant high than those of patients in the control group (P<0.05). Conclusion: Laser vaporization used for treating endometrial polyps has the advantages of short hospitalization time, less complications, safety and effectiveness, and it can effectively promote the recovery of endometrium, so it's worthy of clinical application.

2020 Vol. 28　(1):　127- [Abstract]（ 327 ） HTML (0 KB)  PDF  (0 KB)  ( 39 )

The placenta ages with the gestational time increasing, which is a normal physiological performance, but some placenta ages in advance. Recently, some studies have gradually reported that adverse pregnancy outcomes, such as includes premature rupture of fetal membranes, stillbirth, preeclampsia, and placenta implantation, is associated with abnormal aging of placenta. This article reviews the research progress of the characteristics of placental cell aging and its relationship with pregnancy complications.

2020 Vol. 28　(1):　146- [Abstract]（ 331 ） HTML (0 KB)  PDF  (0 KB)  ( 45 )