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| Influence of cyclosporine A combined with lymphocyte active immunization for treating women with unexplained recurrent spontaneous abortion on their serum T cell subsets level, ACA level and pregnancy outcomes |
| General Hospital of Xinjiang Military Region (Former 44th Hospital of PLA), Xinjiang, 830000 |
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Abstract Objective: To investigate the influence of cyclosporine A (CsA) combined with lymphocyte immunization of T cell (LIT) fro treating women with unexplained recurrent spontaneous abortion (URSA) on their serum T cell subsets, anticardiolipin antibody (ACA) level, and pregnancy outcomes. Methods: 100 pregnant women with URSA were enrolled and were devided into study group and control group (50 cases in each group). The women in the study group were treated by CSA combined with LIT, and the women in the control group were treated by LIT. The levels of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and ACA antibodies (ACA-IgM, ACA-IgG) of all women were observed before and after treatment, and the pregnancy outcomes of women was compared between the two groups. Results: Ather treatment, Values of CD3+, CD4+, and CD4+/CD8+ of women in the study group had increased significantly, but CD8+ value and levels of ACA-IgM and ACA-IgG of women in the study group had decreased significantly, and the change degree of women in the study group were significant more than that of women in the control group (P<0.05). The successful delivery rate of women in the study group was 92.0%, which was significant higher than that (72.0%) of the control group (P<0.05). The incidences of abortion and pregnancy-induced hypertension of women in the study group were 4.0% and 2.0%, which were significant lower than those (18.0% and 16.0%) of women in the control group (P<0.05). Conclusion: CsA combined with LIT used for treating women with URSA can significantly reduce ACA antibody levels, improve immune function, reduce abortion rate, and improve pregnancy outcome, which’s effect is better than LIT used alone.
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