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| Relationship between serum Resistin level and adverse pregnancy outcomes of pregnant women with polycystic ovary syndrome during the first trimester pregnancy |
| The First People's Hospital of Xiaogan, Hubei Province,432000 |
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Abstract Objective: To investigate the expression characteristics of serum Resistin of pregnant women with polycystic ovary syndrome (PCOS) during the first trimester pregnancy, and to analyze its correlation with adverse pregnancy outcomes. Methods: 54 pregnant women with PCOS were selected in study group, and 100 healthy pregnant women were selected in control group. The levels of serum resist, sex hormone binding globulin (SHBG), fasting blood glucose (FPG), and fasting insulin (FINS) of women during the first trimester pregnancy in the two groups were measured, and their correlation with adverse pregnancy outcomes was analyzed. Results: The serum Resist level and HOMA-IR value of women in the study group were significant higher than those of women in the control group, but serum SHBG level was significant lower (P<0.05). In the study group, the serum Resist level and HOMA-IR value of women with good pregnancy outcomes were significant higher than those of women with adverse pregnancy outcomes, but serum SHBG level was significant lower (P<0.05). Correlation analysis showed that the adverse pregnancy outcomes of women in the study group were positively correlated with serum Resist level and HOMA-IR value during the first trimester pregnancy (r=0.416, 0.316, P<0.05), but were negatively correlated with serum SHBG level (r=-0.307, P<0.05). The serum Resist level of women in the study group was most strongly associated with adverse pregnancy outcomes. Conclusion: The serum Resist level of pregnant women with PCOS significantly increases during the first trimester pregnancy, which is positively correlated with pregnancy complications and adverse pregnancy outcomes. The SHBG level and HOMA-IR value can also be used as reference indicators for predicting adverse pregnancy outcomes of women with PCOS.
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