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| Analysis the situation of urinary protein negative conversion of women with preeclampsia at 6 months postpartum and its influence factors |
| Shanghai Changning District Maternal and Child Health Care Hospital, Shanghai, 200051 |
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Abstract Objective: To analyze the situation of urinary protein negative conversion of women with preeclampsia at 6 months postpartum, and to study the influence factors of urinary protein negative conversion. Methods: The women with preeclampsia were selected as the research objects, and were divided into group A (women with severe preeclampsia) and group B (women with mild preeclampsia). The situations of urinary protein negative conversion, drugs used, and continuous positive urine protein were compared between the two groups. Results: The rate of urinary protein negative conversion of all postpartum women was 45.0% at 2-3 days after delivery, 61.9% at 3 months after delivery, or 78.4% at 3 months after delivery, which of women in group A was significant less than that of women in group B (P<0.05). There were no significant different in age, BMI, gestational weeks when delivery, value of diastolic blood pressure, and the levels of urea nitrogen and uric acid of the women between the two groups (P>0.05). In 6 months after delivery, the ratio of antihypertensive drugs used before delivery and within 48 hours postpartum of women with protein- positive was significant lower than that of women with protein-negative (P<0.05), but the ratio of magnesium sulfate and low-molecular heparin calcium used before delivery and within 48 hours postpartum had no significant different between women with protein- positive and women with protein-negative (P>0.05). Urine protein quantitative ≥2.5g/24h and no antihypertensive drugs used before delivery and within 48 hours postpartum were the influencing factors of continuous positive urine protein of women in 6 month after delivery (P<0.05), but the onset time ≤30 gestational weeks, systolic blood pressure ≥155mmHg, and creatinine ≥67umol/L had no relevant to continuous positive urine protein of women in 6 months after delivery (P>0.05). Conclusion: The urine protein of 78.4% women with preeclampsia will turn to negative within 6 month after delivery. Quantitative of urine protein high and no antihypertensive drugs used may reduce the rate of urine protein negative urine in 6 months after delivery.
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