|
Abstract Objective: To analyze the effect of different doses of propylthiouracil for treating pregnant women with hyperthyroidism on their pregnancy outcomes and coagulation function. Methods: 150 pregnant women with hyperthyroidism were randomly divided into control group (75 women treated by 150 mg propylthiouracil daily) and study group (75 women trested by 300 mg propylthiouracil daily) from January 2015 and December 2017. The pregnancy outcomes, liver function, thyroid function, coagulation function, and therapeutic effect of women were compared between the two groups. Results: After treatment, the levels of ALP, GGT,TBIL (TBIL), ALT and AST of women in the study group were significant higher than those of women in the control group, but the levels of TSH,FT4,FT3, TT4, PT, TT, FIB, and DD of women in the study group were significant lower (P<0.05). The total effective rate of women in the study group was 92.0%, which was significant higher than that (77.3%) of women in the control group (P<0.05). The incidences of cesarean section, premature delivery, pregnancyinduced hypertension, heart failure, and severe eclampsia of women, and rates of neonatal fetal distress, hyperthyroidism, and low birth weight infants in the study group were significantly lower than those of women in the control group (P<0.05). Conclusion: Highdose propylthiomidine for treating pregnant women with hyperthyroidism can not only control hyperthyroidism during pregnancy, alleviate hypercoagulability of women, but also improve the outcomes of the mothers and infants, but it has a certain impact on the liver function of women, so it is need to pay close attention to the liver function of women.
|
